Integrated computational approaches for identification of potent pyrazole-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, virtual screening, docking, MM/GBSA, EC, MD simulation studies DOI

Desu Gayathri Niharika,

Punam Salaria, Amarendar Reddy M

и другие.

Molecular Diversity, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Язык: Английский

Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database DOI Creative Commons
Shihao Chen,

Wenqiang Fang,

Linqian Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 15, 2024

Objective: This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering third quarter of 2020 second 2023. Methods: Data related cenobamate-associated ADEs 2023 were collected. After standardizing data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, employed for analysis. Results: Among 2535 ADE reports where was primary suspected drug, 94 reactions involving 11 different System Organ Class (SOC) categories identified through application four techniques. More specifically, neurological disorders injuries resultant complications are frequent cenobamate. Conclusion: Our research findings align established results, affirming favorable safety profile Effective prevention induced by can be achieved establishment efficient blood concentration monitoring dose adjustments.

Язык: Английский

Процитировано

12

Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway DOI Creative Commons
Shihao Chen,

Linqian Zhao,

Xing Jin

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment

Язык: Английский

Процитировано

2

Validation of the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) in Western China DOI Creative Commons
Chen Liu,

Lan Mou,

Yuwen Zhang

и другие.

Seizure, Год журнала: 2025, Номер 125, С. 87 - 93

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1

Disease burden and related risk factors of esophageal cancer in China and globally from 1990 to 2021, with forecast to 2035: An analysis and comparison DOI Creative Commons
Mimi Wang, Huiwen Miao

Tobacco Induced Diseases, Год журнала: 2024, Номер 22(August), С. 1 - 11

Опубликована: Авг. 1, 2024

1. Rogers JE, Sewastjanow-Silva M, Waters RE, Ajani JA. Esophageal cancer: emerging therapeutics. Expert Opin Ther Targets. 2022;26(2):107-117. doi:10.1080/14728222.2022.2036718 CrossRef Google Scholar

Язык: Английский

Процитировано

6

Global incidence, prevalence, deaths, and disability-adjusted life-years (DALYs) for idiopathic epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 DOI Creative Commons
Lin Chen, Yang Miao,

Tianxiang Zhang

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Abstract Background: Epilepsy poses a significant global health burden. And idiopathic epilepsy (IE) constitutes substantial proportion of cases worldwide Methods: First, numbers and age-standardized rates incidence, prevalence, deaths disability-adjusted life years (DALYs) were assessed globally by sub-types in 2021. Furthermore, the temporal trend disease burden was explored linear regression model from 1990 to 2019. Finally, Autoregressive Integrated Moving Average (ARIMA) used predict future next 25 years. Results: Exposure IE contributed 3272734 24220856 139851 deaths, 13877827 DALYs Males high-risk populations higher socio-demographic index (SDI) regions areas. The varied considerably across GBD countries. From 2021, number increased. predicted results showed that for both genders would still increase 2022 2046. Conclusion: In conclusion, has threatened public globally. More proactive effective strategic measures should be developed after considering global-specific circumstances.

Язык: Английский

Процитировано

0

Disease burden of lung cancer attributable to metabolic and behavioral risks in China and globally from 1990 to 2021 DOI Creative Commons
Lijun Li,

Xiaoxin Zhang,

Anqi Jiang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Март 7, 2025

There are differences between China and globally in the burden of lung cancer attributed to behavioral metabolic risks. This research utilized Global Burden Disease (GBD) 2021 database extract deaths disability-adjusted life-years (DALYs) risks globally, along with age-standardized mortality rates (ASMR) DALYs (ASDR). The age-period-cohort model was used identify age effects, period cohort as well local net drift. Decomposition analysis quantify relative contributions aging, epidemiological change, population burden. Bayesian for predictive analysis. From 1990 2021, ASMR smoking secondhand smoke significantly decreased but it increased slightly China. And diet low fruits decreased, while due high fasting plasma glucose both globally. drifts were negative values small even close zero -2.06% 0.29%, respectively, among elderly patients has been increasing annually. However, China, decreasing annually across all groups, year by year. In next 15 years, expected decrease Chinese women showed a slow upward trend. Over past thirty global factors attribution factors. only decrease, others have exhibited fluctuating decreases shows trend women. That asks need greater attention tobacco exposure

Язык: Английский

Процитировано

0

Evolving trends and burden of idiopathic epilepsy among children (0–14 years), 1990–2021: a systematic analysis for the Global Burden of Disease study 2021 DOI Creative Commons

Fulai Tu,

Zhijian Tu, Xinrui Jiang

и другие.

Frontiers in Neurology, Год журнала: 2025, Номер 16

Опубликована: Март 17, 2025

This systematic analysis aims to elucidate the trends and burden of idiopathic epilepsy among children aged 0 14 from 1990 2021, utilizing Global Burden Disease (GBD) 2021 data explore demographic geographical variations, highlight progress, identify ongoing challenges. Data were sourced GBD database, focusing on 0-14. Annual absolute numbers age-standardized rates for incidence (ASIR), prevalence (ASPR), mortality (ASMR), disability-adjusted life years (ASDR) retrieved. Joinpoint regression analyses assessed changes over time, calculating average annual percentage change (AAPC) statistics. collation visualizations conducted using R software, with statistical significance established at a p-value threshold 0.05. In there 1,227,191 incident cases, 6,095,769 prevalent 3,564,497 DALYs, 18,171 deaths due globally. The ASIR increased by 0.27% 55.74 61.35 per 100,000 population 2021. contrast, ASPR (AAPC = -0.03), ASMR -1.60), ASDR -1.01) all decreased. Regionally, low-middle SDI region had highest burden, while high ASPR. low experienced ASDR. Significant regional variations noted, African Region exhibiting ASDR, Western Pacific lowest. Nationally, substantial observed across 204 countries, notable differences in ASIR, ASPR, ASMR, Despite overall declines slight increase disparities Low regions continue bear higher underscoring need targeted interventions improved healthcare access. Future efforts should focus strengthening systems, enhancing diagnostic treatment capabilities, increasing awareness, particularly resource-limited regions.

Язык: Английский

Процитировано

0

Global, regional, and national burden of refraction disorders: findings from the global burden of disease study 2021 and projections to 2050 DOI Creative Commons
Miaomiao Dai, Yi Ouyang

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0

Burden of Chronic obstructive pulmonary disease in China: an analysis based on the GBD 2021 compared with the United States DOI Creative Commons

Rong Li,

Yu Li,

Chan Xiong

и другие.

PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0321470 - e0321470

Опубликована: Апрель 17, 2025

Background Chronic obstructive pulmonary disease is an important affecting physical health worldwide, and the burden of this has been growing since 1991 for both China US. Objective To examine changes in COPD US between 1990–2021. Methods The joinpoint analysis, age-Period-Cohort decomposition predictive analysis methods were used to describe prevalence, incidence, death, disability-adjusted life years Results Compared with China, all four measures higher than they had 1990. increases age China. Conversely, US, getting younger. epidemiological have contributed increasing but led a decline By 2042, number cases countries will rise, especially death rate Conclusion not rapidly short term, as well global community, must take seriously.

Язык: Английский

Процитировано

0

Non-invasive Localization of Epileptogenic Zone in Drug-Resistant Epilepsy Based on Time–Frequency Analysis and VGG Convolutional Neural Network DOI Creative Commons
Yaqing Liu, Yalin Wang, Tiancheng Wang

и другие.

Bioengineering, Год журнала: 2025, Номер 12(5), С. 443 - 443

Опубликована: Апрель 23, 2025

The mainstream method for treating drug-resistant epilepsy (DRE) is surgical resection of the epileptogenic zone. Non-invasive automatic localization zone can be used to guide electrode implantation and improve effectiveness safety neurosurgical treatments. Previous researchers have proposed a range methods this purpose, but these suffer from limits such as unclear post-operative outcomes, invasiveness, limited data volume, single DRE type. This study constructed non-invasive method, integrating sLORETA source imaging, time-frequency analysis, Visual Geometry Group (VGG-16) deep learning. Firstly, 16-channel scalp electroencephalogram (EEG) 25 successfully operated patients were included. Secondly, features by short-time Fourier transform (STFT), continuous wavelet (CWT), superlets algorithm extracted. Finally, VGG-16 network was applied automatically locate All three feature extraction achieved significant accuracy on dataset. Using STFT processing combining it with image classification an average 80.2% channel identification rate 80.7% zones. After CWT, increased 81.7% recognition 81.4%. further improved 83.1%, 83.3%. marks pioneering proposal systematic framework

Язык: Английский

Процитировано

0