Molecular Diversity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Язык: Английский
Molecular Diversity, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Март 15, 2024
Objective: This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering third quarter of 2020 second 2023. Methods: Data related cenobamate-associated ADEs 2023 were collected. After standardizing data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, employed for analysis. Results: Among 2535 ADE reports where was primary suspected drug, 94 reactions involving 11 different System Organ Class (SOC) categories identified through application four techniques. More specifically, neurological disorders injuries resultant complications are frequent cenobamate. Conclusion: Our research findings align established results, affirming favorable safety profile Effective prevention induced by can be achieved establishment efficient blood concentration monitoring dose adjustments.
Язык: Английский
Процитировано
12CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)
Опубликована: Фев. 1, 2025
ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment
Язык: Английский
Процитировано
2Seizure, Год журнала: 2025, Номер 125, С. 87 - 93
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
1Tobacco Induced Diseases, Год журнала: 2024, Номер 22(August), С. 1 - 11
Опубликована: Авг. 1, 2024
1. Rogers JE, Sewastjanow-Silva M, Waters RE, Ajani JA. Esophageal cancer: emerging therapeutics. Expert Opin Ther Targets. 2022;26(2):107-117. doi:10.1080/14728222.2022.2036718 CrossRef Google Scholar
Язык: Английский
Процитировано
6Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Март 7, 2025
There are differences between China and globally in the burden of lung cancer attributed to behavioral metabolic risks. This research utilized Global Burden Disease (GBD) 2021 database extract deaths disability-adjusted life-years (DALYs) risks globally, along with age-standardized mortality rates (ASMR) DALYs (ASDR). The age-period-cohort model was used identify age effects, period cohort as well local net drift. Decomposition analysis quantify relative contributions aging, epidemiological change, population burden. Bayesian for predictive analysis. From 1990 2021, ASMR smoking secondhand smoke significantly decreased but it increased slightly China. And diet low fruits decreased, while due high fasting plasma glucose both globally. drifts were negative values small even close zero -2.06% 0.29%, respectively, among elderly patients has been increasing annually. However, China, decreasing annually across all groups, year by year. In next 15 years, expected decrease Chinese women showed a slow upward trend. Over past thirty global factors attribution factors. only decrease, others have exhibited fluctuating decreases shows trend women. That asks need greater attention tobacco exposure
Язык: Английский
Процитировано
0Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Март 17, 2025
This systematic analysis aims to elucidate the trends and burden of idiopathic epilepsy among children aged 0 14 from 1990 2021, utilizing Global Burden Disease (GBD) 2021 data explore demographic geographical variations, highlight progress, identify ongoing challenges. Data were sourced GBD database, focusing on 0-14. Annual absolute numbers age-standardized rates for incidence (ASIR), prevalence (ASPR), mortality (ASMR), disability-adjusted life years (ASDR) retrieved. Joinpoint regression analyses assessed changes over time, calculating average annual percentage change (AAPC) statistics. collation visualizations conducted using R software, with statistical significance established at a p-value threshold 0.05. In there 1,227,191 incident cases, 6,095,769 prevalent 3,564,497 DALYs, 18,171 deaths due globally. The ASIR increased by 0.27% 55.74 61.35 per 100,000 population 2021. contrast, ASPR (AAPC = -0.03), ASMR -1.60), ASDR -1.01) all decreased. Regionally, low-middle SDI region had highest burden, while high ASPR. low experienced ASDR. Significant regional variations noted, African Region exhibiting ASDR, Western Pacific lowest. Nationally, substantial observed across 204 countries, notable differences in ASIR, ASPR, ASMR, Despite overall declines slight increase disparities Low regions continue bear higher underscoring need targeted interventions improved healthcare access. Future efforts should focus strengthening systems, enhancing diagnostic treatment capabilities, increasing awareness, particularly resource-limited regions.
Язык: Английский
Процитировано
0BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 2, 2025
Язык: Английский
Процитировано
0PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0321470 - e0321470
Опубликована: Апрель 17, 2025
Background Chronic obstructive pulmonary disease is an important affecting physical health worldwide, and the burden of this has been growing since 1991 for both China US. Objective To examine changes in COPD US between 1990–2021. Methods The joinpoint analysis, age-Period-Cohort decomposition predictive analysis methods were used to describe prevalence, incidence, death, disability-adjusted life years Results Compared with China, all four measures higher than they had 1990. increases age China. Conversely, US, getting younger. epidemiological have contributed increasing but led a decline By 2042, number cases countries will rise, especially death rate Conclusion not rapidly short term, as well global community, must take seriously.
Язык: Английский
Процитировано
0Bioengineering, Год журнала: 2025, Номер 12(5), С. 443 - 443
Опубликована: Апрель 23, 2025
The mainstream method for treating drug-resistant epilepsy (DRE) is surgical resection of the epileptogenic zone. Non-invasive automatic localization zone can be used to guide electrode implantation and improve effectiveness safety neurosurgical treatments. Previous researchers have proposed a range methods this purpose, but these suffer from limits such as unclear post-operative outcomes, invasiveness, limited data volume, single DRE type. This study constructed non-invasive method, integrating sLORETA source imaging, time-frequency analysis, Visual Geometry Group (VGG-16) deep learning. Firstly, 16-channel scalp electroencephalogram (EEG) 25 successfully operated patients were included. Secondly, features by short-time Fourier transform (STFT), continuous wavelet (CWT), superlets algorithm extracted. Finally, VGG-16 network was applied automatically locate All three feature extraction achieved significant accuracy on dataset. Using STFT processing combining it with image classification an average 80.2% channel identification rate 80.7% zones. After CWT, increased 81.7% recognition 81.4%. further improved 83.1%, 83.3%. marks pioneering proposal systematic framework
Язык: Английский
Процитировано
0