Characteristics and treatment of midlife‐onset epilepsy: A 24‐year single‐center, retrospective study DOI
Xu Zhang, Xiang Feng,

Xiao-bing Shi

et al.

Epileptic Disorders, Journal Year: 2024, Volume and Issue: 26(5), P. 600 - 608

Published: June 19, 2024

Abstract Objective This study aimed to analyze the clinical characteristics, etiology, and treatment of midlife‐onset epilepsy in a real‐world setting at single center China. Methods The data patients who attended clinic Department Neurology, First Medical Center Chinese PLA General Hospital from February 1999 March 2023 were retrospectively analyzed. risk factors for over past 24 years Results Of 969 with onset 45–64 age, 914 diagnosed least two unprovoked seizures h apart. those, 99.7% (911) focal origin. median duration initial seizure follow‐up was 2 months (interquartile range [IQR]: 1.0–6.0 months). Before commencing treatment, 30.2% (207/683) experienced more than seizures. A structural etiology found 66.3% (606/914) patients. Cerebrovascular disease (CVD) traumatic brain injury (TBI) accounted 19.9% (182/914) 16.6% (152/914) cases, respectively. Logistic regression analysis showed that abnormal imaging (odds ratio [OR] 2.04; 95% confidence interval [CI] 1.25–3.32; p = .004), (OR 2.98; 95%CI 1.82–4.87; < .001), clusters 2.40; 1.21–4.73; .01) had poor drug responses. Treatment outcomes generally better after CVD .49; .28–.85; .01). initiation .70; .42–1.15; .16) or 6 first 1.17; .66–2.09; .58) did not result effectiveness. Significance Midlife‐onset is typically being most common cause, tends respond well medication. months. Over 30% before but this affect subsequent outcomes.

Language: Английский

Astaxanthin Inhibits Ferroptosis of Hippocampal Neurons in Kainic Acid‐Induced Epileptic Mice by Activating the Nrf2/GPX4 Signaling Pathway DOI Creative Commons
Shihao Chen,

Linqian Zhao,

Xing Jin

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(2)

Published: Feb. 1, 2025

ABSTRACT Background Epilepsy, a prevalent neurological disorder, is distinguished by episodic abnormal discharges of neurons within the brain, resulting in transient brain dysfunction. Prior research has identified novel form cell death termed ferroptosis, which intricately linked to initiation and progression epilepsy. It been demonstrated that astaxanthin (AST) can inhibit ferroptosis enhancing activity nuclear factor erythroid 2‐related 2 (Nrf2), thereby providing cytoprotection. Therefore, this study aims investigate whether AST alleviate neuronal epilepsy activating Nrf2/GPX4 pathway, exerting neuroprotective effect. Methods By constructing kainic acid (KA)‐induced mouse model KA‐induced HT22 model, we employed behavioral testing, Western blot analysis, quantitative real‐time reverse transcription qRT‐PCR, ferroptosis‐related assay kits, immunofluorescence staining, other methods. These methodologies were utilized protective effects underlying mechanisms on epileptic mice neurons. Results Our results demonstrate pretreatment alleviates behaviors cognitive impairments mitigates indicators such as lipid peroxidation mitochondrial morphological alterations. This effect appears be mediated activation signaling axis. In vitro studies further revealed confers neuroprotection against death, an abrogated Nrf2 inhibitor. Hence, properties are significantly associated with modulation Nrf2‐mediated corroborated bioinformatics analyses. Conclusion The effectively inhibits both vivo models via pathway. finding suggests holds promise potential therapeutic agent for treatment

Language: Английский

Citations

2
Safety assessment of cenobamate: real-world adverse event analysis from the FAERS database DOI Creative Commons
Shihao Chen,

Wenqiang Fang,

Linqian Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Objective: This study aims to analyze adverse drug events (ADEs) associated with cenobamate from the FAERS database, covering third quarter of 2020 second 2023. Methods: Data related cenobamate-associated ADEs 2023 were collected. After standardizing data, various signal quantification techniques, including ROR, MHRA, BCPNN, and MGPS, employed for analysis. Results: Among 2535 ADE reports where was primary suspected drug, 94 reactions involving 11 different System Organ Class (SOC) categories identified through application four techniques. More specifically, neurological disorders injuries resultant complications are frequent cenobamate. Conclusion: Our research findings align established results, affirming favorable safety profile Effective prevention induced by can be achieved establishment efficient blood concentration monitoring dose adjustments.

Language: Английский

Citations

12
Validation of the Chinese version of the Epilepsy Anxiety Survey Instrument (EASI) and its brief version (brEASI) in Western China DOI Creative Commons
Chen Liu,

Lan Mou,

Yuwen Zhang

et al.

Seizure, Journal Year: 2025, Volume and Issue: 125, P. 87 - 93

Published: Jan. 5, 2025

Language: Английский

Citations

1
Global incidence, prevalence, deaths, and disability-adjusted life-years (DALYs) for idiopathic epilepsy, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 DOI Creative Commons
Lin Chen, Yang Miao,

Tianxiang Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background: Epilepsy poses a significant global health burden. And idiopathic epilepsy (IE) constitutes substantial proportion of cases worldwide Methods: First, numbers and age-standardized rates incidence, prevalence, deaths disability-adjusted life years (DALYs) were assessed globally by sub-types in 2021. Furthermore, the temporal trend disease burden was explored linear regression model from 1990 to 2019. Finally, Autoregressive Integrated Moving Average (ARIMA) used predict future next 25 years. Results: Exposure IE contributed 3272734 24220856 139851 deaths, 13877827 DALYs Males high-risk populations higher socio-demographic index (SDI) regions areas. The varied considerably across GBD countries. From 2021, number increased. predicted results showed that for both genders would still increase 2022 2046. Conclusion: In conclusion, has threatened public globally. More proactive effective strategic measures should be developed after considering global-specific circumstances.

Language: Английский

Citations

0
Disease burden of lung cancer attributable to metabolic and behavioral risks in China and globally from 1990 to 2021 DOI Creative Commons
Lijun Li,

Xiaoxin Zhang,

Anqi Jiang

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 7, 2025

There are differences between China and globally in the burden of lung cancer attributed to behavioral metabolic risks. This research utilized Global Burden Disease (GBD) 2021 database extract deaths disability-adjusted life-years (DALYs) risks globally, along with age-standardized mortality rates (ASMR) DALYs (ASDR). The age-period-cohort model was used identify age effects, period cohort as well local net drift. Decomposition analysis quantify relative contributions aging, epidemiological change, population burden. Bayesian for predictive analysis. From 1990 2021, ASMR smoking secondhand smoke significantly decreased but it increased slightly China. And diet low fruits decreased, while due high fasting plasma glucose both globally. drifts were negative values small even close zero -2.06% 0.29%, respectively, among elderly patients has been increasing annually. However, China, decreasing annually across all groups, year by year. In next 15 years, expected decrease Chinese women showed a slow upward trend. Over past thirty global factors attribution factors. only decrease, others have exhibited fluctuating decreases shows trend women. That asks need greater attention tobacco exposure

Language: Английский

Citations

0
Ten‐year projection of adult epilepsy burden in Australia DOI Creative Commons
Gopisankar Mohanannair Geethadevi, Kristoffer Jarlov Jensen, Patrick Kwan

et al.

Epilepsia, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Objective The World Health Organization's Intersectoral Global Action Plan on Epilepsy and Other Neurological Disorders calls for more epilepsy care centers, but a population‐level estimate of epilepsy's projected burden to justify this investment from societal perspective is lacking. We aimed project the using dynamic life table modeling including number deaths, years life, quality‐adjusted (QALYs), productivity‐adjusted (PALYs), health costs, people be screened surgical eligibility in Australian adult population (aged 18–80 years) 2024 2033. Methods A model was developed capture incident prevalent Australia, five states: not seizure‐free non‐drug resistant (NSF‐NDRE), (SF‐NDRE), drug (NSF‐DRE), drug‐resistant (SF‐DRE), death 1‐year cycles. inputs came published studies, Glosgow cohort study Project. Results In 10 years, 82 723 adults had epilepsy, whereas 125 223 formed cohort. Over experienced 15 227 deaths accrued 1 209 280 distributed as 23.6% NSF‐NDRE, 58.3% SF‐NDRE, 15.8% NSF‐DRE, 2.1% SF‐DRE. 992 812 QALYs 442 600 PALYs. Total costs reached $14.2 billion US dollars (USD), which NSF‐DRE contributed 35%. Uncontrolled seizures resulted loss 84 881 QALYs, 19 333 PALYs, $4.5 USD, 4603 lives. total 665 individuals were eligible evaluation, with an additional 383 annually through Significance This model, based current standard demonstrates quality impact, productivity loss, cost due uncontrolled resistance, supporting need further care. approach can applied other countries inform policy decisions perspective.

Language: Английский

Citations

0
Disease burden and related risk factors of esophageal cancer in China and globally from 1990 to 2021, with forecast to 2035: An analysis and comparison DOI Creative Commons
Mimi Wang, Huiwen Miao

Tobacco Induced Diseases, Journal Year: 2024, Volume and Issue: 22(August), P. 1 - 11

Published: Aug. 1, 2024

1. Rogers JE, Sewastjanow-Silva M, Waters RE, Ajani JA. Esophageal cancer: emerging therapeutics. Expert Opin Ther Targets. 2022;26(2):107-117. doi:10.1080/14728222.2022.2036718 CrossRef Google Scholar

Language: Английский

Citations

3
Evolving trends and burden of idiopathic epilepsy among children (0–14 years), 1990–2021: a systematic analysis for the Global Burden of Disease study 2021 DOI Creative Commons

Fulai Tu,

Zhijian Tu, Xinrui Jiang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 17, 2025

This systematic analysis aims to elucidate the trends and burden of idiopathic epilepsy among children aged 0 14 from 1990 2021, utilizing Global Burden Disease (GBD) 2021 data explore demographic geographical variations, highlight progress, identify ongoing challenges. Data were sourced GBD database, focusing on 0-14. Annual absolute numbers age-standardized rates for incidence (ASIR), prevalence (ASPR), mortality (ASMR), disability-adjusted life years (ASDR) retrieved. Joinpoint regression analyses assessed changes over time, calculating average annual percentage change (AAPC) statistics. collation visualizations conducted using R software, with statistical significance established at a p-value threshold 0.05. In there 1,227,191 incident cases, 6,095,769 prevalent 3,564,497 DALYs, 18,171 deaths due globally. The ASIR increased by 0.27% 55.74 61.35 per 100,000 population 2021. contrast, ASPR (AAPC = -0.03), ASMR -1.60), ASDR -1.01) all decreased. Regionally, low-middle SDI region had highest burden, while high ASPR. low experienced ASDR. Significant regional variations noted, African Region exhibiting ASDR, Western Pacific lowest. Nationally, substantial observed across 204 countries, notable differences in ASIR, ASPR, ASMR, Despite overall declines slight increase disparities Low regions continue bear higher underscoring need targeted interventions improved healthcare access. Future efforts should focus strengthening systems, enhancing diagnostic treatment capabilities, increasing awareness, particularly resource-limited regions.

Language: Английский

Citations

0
Global, regional, and national burden of refraction disorders: findings from the global burden of disease study 2021 and projections to 2050 DOI Creative Commons
Miaomiao Dai, Yi Ouyang

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 2, 2025

Language: Английский

Citations

0
Burden of Chronic obstructive pulmonary disease in China: an analysis based on the GBD 2021 compared with the United States DOI Creative Commons

Rong Li,

Yu Li,

Chan Xiong

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321470 - e0321470

Published: April 17, 2025

Background Chronic obstructive pulmonary disease is an important affecting physical health worldwide, and the burden of this has been growing since 1991 for both China US. Objective To examine changes in COPD US between 1990–2021. Methods The joinpoint analysis, age-Period-Cohort decomposition predictive analysis methods were used to describe prevalence, incidence, death, disability-adjusted life years Results Compared with China, all four measures higher than they had 1990. increases age China. Conversely, US, getting younger. epidemiological have contributed increasing but led a decline By 2042, number cases countries will rise, especially death rate Conclusion not rapidly short term, as well global community, must take seriously.

Language: Английский

Citations

0