Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine

Trends in Immunology, Год журнала: 2024, Номер 45(10), С. 799 - 813

Опубликована: Сен. 21, 2024

Язык: Английский

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Psychedelics in neuroinflammation: Mechanisms and therapeutic potential

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111278 - 111278

Опубликована: Янв. 1, 2025

Язык: Английский

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Pharmacological and Therapeutic Innovation to Mitigate Radiation-Induced Cognitive Decline (RICD) in Brain Tumor Patients

Cancer Letters, Год журнала: 2025, Номер unknown, С. 217700 - 217700

Опубликована: Апрель 1, 2025

Язык: Английский

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Complosome as a new intracellular regulatory network in both normal and malignant hematopoiesis

Leukemia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Язык: Английский

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Decoding complement: Novel disease insights and therapeutic horizons

European Journal of Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

Язык: Английский

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Complement system alteration in iPSC-derived astrocytes from individuals with Down syndrome

Опубликована: Окт. 28, 2024

Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21, occurs in 1 700–1,000 live births. Neuroinflammation is increasingly recognized as a critical contributor to DS neuropathology, although its underlying drivers remain unclear. In this study, we analyzed available single-nucleus RNA sequencing data postmortem cortical brain samples individuals with and controls aged 36 years younger, identifying significant alterations complement system gene sets. We validated these findings using astrocytes differentiated urine-derived induced pluripotent stem cells (iPSCs) (T21-iPSC), marking the first study assess expression protein levels components T21-iPSC-derived astrocytes. Our results revealed distinct phenotypic changes astrocytes, including enlarged cell nuclear sizes, enhanced glutamate uptake. Elevated C5aR1 MASP1 transcripts, well increased C4 secretion culture supernatants, suggest dysregulation DS. These underscore role pathway neuropathogenesis point potential therapeutic targets improve quality life for

Язык: Английский

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Complement System and Adhesion Molecule Skirmishes in Fabry Disease: Insights into Pathogenesis and Disease Mechanisms

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12252 - 12252

Опубликована: Ноя. 14, 2024

Fabry disease is a rare X-linked lysosomal storage disorder caused by mutations in the galactosidase alpha (

Язык: Английский

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