Neuromethods,
Год журнала:
2023,
Номер
unknown, С. 193 - 203
Опубликована: Сен. 20, 2023
This
chapter
discusses
methodological
issues
when
applying
transcutaneous
stimulation
of
the
aural
branch
vagus
nerve
(taVNS)
to
language
research.
We
review
a
handful
studies
that
have
investigated
learning
using
taVNS.
Subheading
1
provides
general
introduction
and
describes
potential
impact
taVNS
on
2
considerations
technique
research,
including
preparation
linguistic
materials,
eligibility
participants,
experimental
design,
types
training,
assessment
learning,
parameter
settings
3
gives
examples
summarizes
results
from
previous
differ
one
another
with
respect
methods
used.
4
concludes
this
future
directions
for
Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Июль 6, 2023
Vagus
nerve
stimulation
(VNS)
is
a
technology
that
provides
electrical
to
the
cervical
vagus
and
can
be
applied
in
treatment
of
wide
variety
neuropsychiatric
systemic
diseases.
VNS
exerts
its
effect
by
stimulating
vagal
afferent
efferent
fibers,
which
project
upward
brainstem
nuclei
relayed
circuits
downward
internal
organs
influence
autonomic,
neuroendocrine,
neuroimmunology
systems.
The
neuroimmunomodulation
mediated
through
cholinergic
anti-inflammatory
pathway
regulates
immune
cells
decreases
pro-inflammatory
cytokines.
Traditional
non-invasive
have
Food
Drug
Administration
(FDA)-approved
indications
for
patients
with
drug-refractory
epilepsy,
treatment-refractory
major
depressive
disorders,
headaches.
number
clinical
trials
translational
studies
explore
therapeutic
potentials
mechanisms
increasing.
In
this
review,
we
first
introduced
anatomical
physiological
bases
immunomodulating
functions
VNS.
We
covered
investigated
implications
spectrum
brain
disorders
diseases
context
neuroimmunomodulation.
PLoS ONE,
Год журнала:
2022,
Номер
17(6), С. e0270096 - e0270096
Опубликована: Июнь 16, 2022
Background
Dysphagia
is
a
common
yet
serious
complication
in
stroke
patients.
We
aimed
to
conduct
meta-analysis
and
systematic
review
evaluate
the
risk
factors
of
dysphagia
patients
with
ischemic
stroke,
provide
insights
clinical
treatment
nursing
care
dysphagia.
Methods
searched
PubMed,
Embase,
Cochrane
Library,
Web
Science,
China
National
Knowledge
Infrastructure
(CNKI)
Wanfang
Database,
Biomedical
Literature
Database
(CBM)
for
studies
on
up
January
31,
2022.
The
quality
literature
was
evaluated
using
Newcastle-Ottawa
scale.
Meta-analysis
performed
RevMan
5.3
software.
Results
A
total
10
involving
4637
were
included,
1183(25.51%)
had
after
stroke.
synthesized
outcomes
showed
that
elder
age
(SMD
=
0.42,
95%CI:0.34–0.50),
hypertension
(OR
1.96,
95%CI:1.48–2.61),
diabetes
1.83,
95%CI:1.47–2.28),
brainstem
2.12,
95%CI:1.45–3.09)
associated
(all
P<0.05).
There
no
significant
difference
gender
between
1.07,
95%CI:0.91–1.27,
P
0.40).
Egger
regression
tests
indicated
there
publication
biases
P>0.05).
Conclusions
Elder
age,
hypertension,
are
development
Attention
should
be
paid
assessment
early
intervention
those
improve
prognosis
Brain stimulation,
Год журнала:
2023,
Номер
16(5), С. 1252 - 1258
Опубликована: Авг. 17, 2023
Vagus
nerve
stimulation
(VNS)
has
gained
enormous
traction
as
a
promising
bioelectronic
therapy.
In
particular,
the
delivery
of
VNS
paired
with
training
to
promote
neural
changes
demonstrated
clinical
success
for
stroke
recovery
and
found
far-reaching
application
in
other
domains,
from
autism
psychiatric
disorders
normal
learning.
The
been
extensively
documented.
Here,
we
consider
more
unusual
question:
why
does
have
such
broad
utility,
perhaps
importantly,
when
not
work?
We
present
discussion
concepts
that
underlie
therapy
an
anthology
studies
describe
conditions
which
these
are
violated
fails.
focus
specifically
on
mechanisms
engaged
by
implanted
VNS,
how
parameters
stimulation,
method,
pharmacological
manipulations,
accompanying
comorbidities,
specifics
concurrent
interact
impact
efficacy
As
is
increasing
translated
implementation,
clear
understanding
it
does,
critically,
work
fundamental
this
approach.
Frontiers in Integrative Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Фев. 19, 2024
Bioelectronic
Medicine
stands
as
an
emerging
field
that
rapidly
evolves
and
offers
distinctive
clinical
benefits,
alongside
unique
challenges.
It
consists
of
the
modulation
nervous
system
by
precise
delivery
electrical
current
for
treatment
conditions,
such
post-stroke
movement
recovery
or
drug-resistant
disorders.
The
unquestionable
impact
is
underscored
successful
translation
to
humans
in
last
decades,
long
list
preclinical
studies.
Given
emergency
accelerating
progress
new
neuromodulation
treatments
(i.e.,
hypertension,
autoimmune
degenerative
diseases),
collaboration
between
multiple
fields
imperative.
This
work
intends
foster
multidisciplinary
bring
together
different
provide
fundamental
basis
underlying
Medicine.
In
this
review
we
will
go
from
biophysics
cell
membrane,
which
consider
inner
core
neuromodulation,
patient
care.
We
discuss
recently
discovered
mechanism
neurotransmission
switching
how
it
design,
update
on
neuronal
glial
health
disease.
advances
biomedical
technology
have
facilitated
collection
large
amounts
data,
thereby
introducing
challenges
data
analysis.
approaches
high
throughput
analysis,
encompassing
big
networks,
artificial
intelligence,
internet
things.
Emphasis
be
placed
understanding
electrochemical
properties
neural
interfaces,
along
with
integration
biocompatible
reliable
materials
compliance
regulations
translational
applications.
Preclinical
validation
foundational
process,
critical
aspects
animal
Finally,
focus
point-of-care
ultimate
goal
bioelectronic
medicine.
a
call
scientists
common
endeavor:
accelerate
decoding
era
therapeutic
possibilities.
Frontiers in Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Фев. 16, 2022
Stroke
poses
a
serious
threat
to
human
health
and
burdens
both
society
the
healthcare
system.
Standard
rehabilitative
therapies
may
not
be
effective
in
improving
functions
after
stroke,
so
alternative
strategies
are
needed.
The
FDA
has
approved
vagus
nerve
stimulation
(VNS)
for
treatment
of
epilepsy,
migraines,
depression.
Recent
studies
have
demonstrated
that
VNS
can
facilitate
benefits
rehabilitation
interventions.
coupled
with
upper
limb
enhances
recovery
function
patients
chronic
stroke.
However,
its
invasive
nature
limits
clinical
application.
Researchers
developed
non-invasive
method
stimulate
(non-invasive
stimulation,
nVNS).
It
been
suggested
nVNS
could
promising
muscle
stroke
patients.
In
this
article,
we
review
current
researches
preclinical
as
well
potential
applications
We
summarize
parameters,
advantages,
mechanisms,
adverse
effects
applications,
future
challenges
directions
cerebral
treatment.
These
indicate
efficacy
reducing
volume
attenuating
neurological
deficits
ischemic
models.
While
more
basic
research
is
required
fully
understand
mechanisms
efficacy,
especially
Phase
III
trials
large
number
patients,
these
data
suggest
applied
easily
only
possible
secondary
prophylactic
but
also
adjunctive
acute
near
future.
The Journal of Physiology,
Год журнала:
2024,
Номер
603(3), С. 723 - 735
Опубликована: Сен. 7, 2024
Paired
vagus
nerve
stimulation
(VNS)
has
emerged
as
a
promising
strategy
to
potentiate
recovery
after
neurological
injury.
This
approach,
which
combines
short
bursts
of
electrical
the
with
rehabilitation
exercises,
received
approval
from
US
Food
and
Drug
Aministration
in
2021
first
neuromodulation-based
therapy
for
chronic
stroke.
Because
this
treatment
is
increasingly
implemented
clinical
practice,
there
need
take
stock
what
we
know
about
approach
have
yet
learn.
Here,
provide
survey
on
foundational
basis
VNS
stroke
offer
insight
into
mechanisms
that
underlie
potentiated
recovery,
focusing
principles
neuromodulatory
reinforcement.
We
discuss
current
state
observations
regarding
synaptic
reorganization
motor
networks
are
enhanced
by
VNS,
propose
other
prospective
loci
neuromodulation
should
be
evaluated
future.
Finally,
highlight
future
opportunities
challenges
faced
translated
use.
Collectively,
clearer
understanding
mechanistic
may
reveal
ways
maximize
its
benefits.
Medical Science Monitor,
Год журнала:
2022,
Номер
28
Опубликована: Ноя. 9, 2022
Stroke
is
a
disease
with
high
incidence
and
disability
rate,
resulting
in
changes
neural
network
corticoid-subcortical
excitability
various
functional
disabilities.
The
aim
of
the
present
study
was
to
discuss
current
status
research
limitations
potential
direction
application
noninvasive
brain
stimulation
(NIBS)
on
post-stroke
patients.
This
literature
review
focused
clinical
studies
reviews.
Literature
retrieval
conducted
PubMed,
Cochrane,
Scopus,
CNKI,
using
following
keywords:
Repeated
transcranial
magnetic
stimulation,
Transcranial
direct
alternating
ultrasound,
Noninvasive
vagus
nerve
Stroke,
Rehabilitation.
We
selected
200
relevant
publications
from
1985
2022.
An
overview
recent
use
NIBS
patients,
including
its
mechanism,
therapeutic
parameters,
effects,
safety,
presented.
It
found
that
has
positive
effects
dysfunctions
motor,
sensory,
cognitive,
speech,
swallowing,
depression
after
stroke,
but
standardized
stimulus
programs
are
still
lacking.
suggests
rTMS
tDCS
more
beneficial
while
tFUS
tVNS
currently
less
studied
for
rehabilitation,
also
interventions.
Brain Sciences,
Год журнала:
2025,
Номер
15(4), С. 346 - 346
Опубликована: Март 27, 2025
Cerebrovascular
accident
(CVA)
or
stroke
is
a
devastating
neurological
condition
with
dismal
prognosis
associated
recurrent
episodes
that
further
damage
the
neuronal
networks,
thus
disabling
plasticity.
Vagus
nerve
stimulation
(VNS)
has
been
used
in
clinical
practice
to
treat
epilepsy
for
several
decades
and
well
accepted
as
safe
procedure
devoid
of
serious
adverse
events.
Bailey
Bremer
demonstrated
VNS
capabilities
stimulate
pathways
enhance
recovery
damaged
cerebral
function.
Further
studies
have
strengthened
these
observations,
while
technology
improved
tolerability
implants,
resulting
applications
epilepsy.
Several
animal
models
on
neural
plasticity
our
understanding
its
ability
provide
neuromodulation
improve
patients.
The
closed-loop
vagus
individualized
parameters
combined
physical
therapy
appears
be
an
attractive
option
today.
also
being
tested
noninvasive
trans-cutaneous
modality
patient
acceptance
tolerability.
However,
implantation
yielding
desirable
outcomes
more
reliable
treatment
rehabilitation
trials.
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 4, 2025
Background
Stroke
is
a
major
global
health
concern,
imposing
significant
medical
and
social
burdens.
Vagus
nerve
stimulation
(VNS),
an
emerging
neuromodulation
technology,
has
shown
potential
in
the
treatment
of
stroke.
This
bibliometric
analysis
aims
to
explore
knowledge
structure
research
trends
field
VNS
for
stroke
from
2004
2024.
Methods
Publications
were
retrieved
Web
Science
Core
Collection.
CiteSpace
VOSviewer
used
conduct
analyses,
including
author
productivity,
institutional
contributions,
themes
etc.
Results
A
total
191
eligible
publications
analysed.
Kilgard,
M.
P.,
Hays,
S.
A.
most
prolific
authors,
each
contributing
26
publications.
The
USA
(96
publications),
China
(69
Scotland
(17
publications)
countries.
University
Texas
at
Dallas
(33
was
institution,
followed
by
Chongqing
Medical
(19
Glasgow
(15
publications).
Future
expected
focus
on:
(1)
neurophysiological
mechanisms
recovery;
(2)
synergistic
effects
with
other
rehabilitation
therapies;
(3)
comparative
efficacy
non-invasive
transauricular
versus
invasive
VNS;
(4)
safety
effectiveness
post-stroke
functional
impairments
beyond
motor
rehabilitation;
(5)
optimisation
parameters
treatment.
Conclusion
experienced
steady
growth
over
past
two
decades.
provides
valuable
insights
guide
future
research,
clinical
applications,
policy
developments.
