An Exploratory Investigation of Organic Chemicals Detected in Baby Teeth: Differences in Children with and without Autism DOI Creative Commons
Raymond F. Palmer

Journal of Xenobiotics, Год журнала: 2024, Номер 14(1), С. 404 - 415

Опубликована: Март 14, 2024

Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental characterized by deficits in language, communication, and social function with an estimated prevalence rate of between 1 30 44 U.S. births. Gene/environment (G × E) interactions are widely regarded as the most probable explanation for idiopathic ASD, especially because some genes selectively targeted various environmental xenobiotics. Because deciduous teeth likely biomarker utero exposure, present study investigated if quantity chemicals found differs children without ASD. Twenty-two from ASD 20 typically developed were prepared analyzed using THE Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometer (GC GC-TOF MS) ChromaTOF version 23H2 software Agilent 7890 gas chromatograph. The autism sample had significantly more their than typical developing (99.4 vs. 80.7, respectively) (p < 0.0001). majority identified phthalates, plasticizers, pesticides, preservatives, or intermediary solvents used production fragranced personal care cleaning products flavoring agents foods. known toxic analytes reported this biomarkers developmental exposure. Why there greater concentrations that came unclear. A further understanding cavalcade multiple biological system (Interactome) could help future efforts to reduce risks. Notwithstanding, avoidance plastics, scented may be warranted under precautionary principle rule.

Язык: Английский

Aflatoxin B1 Exacerbates Genomic Instability and Apoptosis in the BTBR Autism Mouse Model via Dysregulating DNA Repair Pathway DOI Creative Commons
Ali A. Alshamrani,

Mohammad Y. Alwetaid,

Mohammed A. Al‐Hamamah

и другие.

Toxics, Год журнала: 2023, Номер 11(7), С. 636 - 636

Опубликована: Июль 22, 2023

The pathophysiology of autism is influenced by a combination environmental and genetic factors. Furthermore, individuals with appear to be at higher risk developing cancer. However, this not fully understood. Aflatoxin B1 (AFB1) potent food pollutant carcinogen. effects AFB1 on genomic instability in have yet been investigated. Hence, we aimed investigate whether repeated exposure causes alterations stability, hallmark cancer apoptosis the BTBR mouse model. data revealed increased micronuclei generation, oxidative DNA strand breaks, animals exposed when compared unexposed animals. Lipid peroxidation mice reduction glutathione following exposure, demonstrating an exacerbated redox imbalance. expressions some damage/repair- apoptosis-related genes were also significantly dysregulated. Increases disturbance dysregulation damage/repair pathway are thus important determinants susceptibility AFB1-exacerbated mice. This investigation shows that AFB1-related can accelerate development. Moreover, approaches ameliorate balance may mitigate AFB1-caused instability.

Язык: Английский

Процитировано

4
A hypothesis to explain the potential influence of hormones on the severity of autism spectrum conditions in women DOI
Rosita Dangmann

Medical Hypotheses, Год журнала: 2023, Номер 178, С. 111136 - 111136

Опубликована: Авг. 13, 2023

Язык: Английский

Процитировано

3
The Gluten-Casein-Free Diet in Children with Autism: A Clinical Results of the Ophthalmic and Behavioral Manifestations DOI Creative Commons
Öznur Özge Özcan, İbrahim Şahbaz, Emre Taşdöndüren

и другие.

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi, Год журнала: 2024, Номер 21, С. 828 - 842

Опубликована: Янв. 5, 2024

Aim: To evaluate the ophthalmic and behavioral effects of a gluten-free casein-free diet (GCFD) in autism spectrum disorder (ASD). Method: The study was conducted from November 2020 to January 2023. We designed an 8-week clinical trial GCFD on corneal reflex, pupil size, body mass index (BMI), weight, Autistic Disorder Index, Communication, Social interaction, Stereotype Behavior. Results: A total thirty participants completed trial. reduced BMI [%95 CI -4.8895 -2.1305 (P &lt; 0.0001)], weight -8.5153 -0.0647 = 0.0467)], Index -28.0359 -16.2841 Communication -3.3325 -1.6675 Interaction -4.3190 -2.4010 Behavior -2.3939 -0.2461 =0.01)] significantly. also left -2.2421 -1.6779 &lt;0.0001)] right size -2.2999 -1.7201 Conversely, reflex significantly increased [95% 0.2159 2.1241 0.01)]. No differences were observed for IPD. Conclusion: This suggested that can effectively control ASD behaviors as well regulate autonomic functions related markers such but more research is needed.

Язык: Английский

Процитировано

0
Exploring the Molecular Mechanisms of Acorus tatarinowii and Ginseng in the Treatment of Autism Spectrum Disorder Based on Network Pharmacology and Molecular Docking DOI
Weijun Chen, Yan Wu,

Yuan Hu

и другие.

Current Chinese Science, Год журнала: 2024, Номер 4(2), С. 145 - 157

Опубликована: Фев. 4, 2024

Background: Acorus tatarinowii and Ginseng (AT-G) are traditional Chinese herbal medicines extensively utilized in neurological disorders treatment. However, due to the complex components of AT-G pathological mechanism ASD, mechanisms involved treatment ASD with remain elusive. Objective: We explored potential Methods: used network pharmacology approach evaluate beneficial effects for including obtaining active by Traditional Medicine Systems Pharmacology (TCMSP) platform, detecting targets genes associated Genecards DisGenet databases, analysis, virtual docking. Results: A total 26 components, 130 targets, 806 ASD-related were identified using bioinformatics analysis tool, TCMSP, Genecards, DisGenet. In intersection pharmacodynamic we 41 common targets. Then, GO enrichment revealed that mainly biological processes (i.e., positive regulation nitric oxide biosynthetic process, response xenobiotic stimulus), cellular presynaptic membrane postsynaptic membrane), molecular functions RNA polymerase II transcription factor activity, identical protein binding). KEGG pathway found enriched chemical carcinogenesis - receptor activation, fluid shear stress atherosclerosis, lipid IL-17 signaling pathways. addition, 10 core screened from PPI (e.g., TNF, AKT1, PTGS2, MMP, PPARG, IFNG, NOS2, TGFB1, CASP1). Molecular docking component kaempferol has a high affinity four primary disease Conclusion: Our results facilitated in-depth development their individual provided reference clinical practice

Язык: Английский

Процитировано

0
An Exploratory Investigation of Organic Chemicals Detected in Baby Teeth: Differences in Children with and without Autism DOI Creative Commons
Raymond F. Palmer

Journal of Xenobiotics, Год журнала: 2024, Номер 14(1), С. 404 - 415

Опубликована: Март 14, 2024

Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental characterized by deficits in language, communication, and social function with an estimated prevalence rate of between 1 30 44 U.S. births. Gene/environment (G × E) interactions are widely regarded as the most probable explanation for idiopathic ASD, especially because some genes selectively targeted various environmental xenobiotics. Because deciduous teeth likely biomarker utero exposure, present study investigated if quantity chemicals found differs children without ASD. Twenty-two from ASD 20 typically developed were prepared analyzed using THE Two-Dimensional Gas Chromatography Time-of-Flight Mass Spectrometer (GC GC-TOF MS) ChromaTOF version 23H2 software Agilent 7890 gas chromatograph. The autism sample had significantly more their than typical developing (99.4 vs. 80.7, respectively) (p < 0.0001). majority identified phthalates, plasticizers, pesticides, preservatives, or intermediary solvents used production fragranced personal care cleaning products flavoring agents foods. known toxic analytes reported this biomarkers developmental exposure. Why there greater concentrations that came unclear. A further understanding cavalcade multiple biological system (Interactome) could help future efforts to reduce risks. Notwithstanding, avoidance plastics, scented may be warranted under precautionary principle rule.

Язык: Английский

Процитировано

0