International review of neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
The Journal of Prevention of Alzheimer s Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
5
Frontiers in Veterinary Science, Год журнала: 2023, Номер 10
Опубликована: Июнь 15, 2023
The yaks that inhabit the Tibetan plateau are a rare breed is closely related to local economic development and human civilization. This ancient may have evolved unique gut microbiota due hypoxic high-altitude environment. susceptible external factors, but research regarding effects of different feeding models on fungal community in remains scarce. In this study, we compared analyzed composition variability among wild (WYG), house-feeding domestic (HFG), grazing (GYG). results revealed Basidiomycota Ascomycota were most preponderant phyla community, regardless models. Although types dominant did not change, their abundances did. Intergroup analysis diversity showed Shannon Simpson indices WYG GYG significantly higher than those HFG. Fungal taxonomic there 20 genera (Sclerostagonospora Didymella) between GYG, 16 (Thelebolus Cystobasidium) Furthermore, proportions 14 (Claussenomyces Papiliotrema) decreased, whereas eight (Stropharia Lichtheimia) increased HFG as GYG. Taken together, study indicated structure differ raised breeding groups.
Язык: Английский
Процитировано
11
Diseases, Год журнала: 2024, Номер 12(6), С. 118 - 118
Опубликована: Июнь 3, 2024
According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution
Язык: Английский
Процитировано
4
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155603 - 155603
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
4
Environmental Chemistry and Ecotoxicology, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
Biology Open, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 15, 2025
ABSTRACT The gut microbiome, which is composed of bacteria, viruses, and fungi, involved in multiple essential physiological processes, changes measurably as a person ages, can be associated with negative health outcomes. Microbiome transplants have been proposed method to improve function reduce or reverse disorders, including age-related diseases. Here, we take advantage the laboratory model organism, Drosophila melanogaster, test effects transplanting microbiome young fly into middle-aged flies, across genetic backgrounds both sexes, whether lifespan could increased, late-life physical declines mitigated. Our results suggest that, overall, do not longevity may even detrimental were minor, but sex- genotype-dependent. This discovery supports previous evidence that axenic those no live healthier longer lives than their non-axenic counterparts. this study at least for fruit viable intervention longevity, though more research still warranted.
Язык: Английский
Процитировано
0
Journal of International Medical Research, Год журнала: 2025, Номер 53(2)
Опубликована: Фев. 1, 2025
Objective To characterize the gut microbial composition of patients with optic neuritis (ON) or myasthenia gravis (MG). Methods Stool samples were collected from 45 ON, 13 MG, and 20 healthy controls. Microbial genomic DNA was extracted, V3–V4 regions bacterial 16S rRNA genes amplified sequenced. Bioinformatic analyses performed to compare alpha-diversity, beta-diversity, taxonomic assignments, richness groups. Differences in abundances taxa identified using linear discriminant analysis effect size (LEfSe) variance. Results Beta-diversity showed distinct clustering patient At phylum genus levels, Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria predominated, but their proportions varied between LEfSe that associated each group. The lower certain intestinal probiotics, including Bifidobacterium, Bacteroides, Roseburia, than No significant differences found disease subgroups. Carnobacteriaceae family significantly less abundant ON MG Conclusion We have alterations microbiota importantly, a notable reduction probiotics.
Язык: Английский
Процитировано
0
Gut Pathogens, Год журнала: 2025, Номер 17(1)
Опубликована: Фев. 4, 2025
Abstract Background Infection with the COVID-19-causing pathogen SARS-CoV-2 is associated disruption in human gut microbiome. The microbiome enables protection against diverse pathogens and exhibits dysbiosis during infectious autoimmune disease. Studies based United States China have found that severe COVID-19 cases altered composition when compared to mild cases. We present first study investigate of a population from Sub-Saharan Africa. Given impact geography cultural traditions on composition, it important globally not draw broad conclusions homogenous populations. Results used stool samples Ugandan biobank collected 2020–2022. profiled microbiomes 83 symptomatic individuals who tested positive for along 43 household contacts did any symptoms COVID-19. inclusion healthy controls us generate hypotheses about bacterial strains potentially related susceptibility disease, which highly heterogeneous. Comparison patients their revealed decreased alpha diversity blooms Enterococcus Eggerthella Conclusions Our finds more likely be disrupted, as indicated by increased pathobiont levels. This either consequence disease or may indicate certain states increase findings enable comparison cohorts previously published Global North, well support new interaction between infection.
Язык: Английский
Процитировано
0
Frontiers in Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Фев. 14, 2025
The brain-gut axis (BGA) is emerging as a critical mediator in chronic pain, involving bidirectional communication between the central nervous system and gastrointestinal system. “Pain Matrix” associated with microbial dysbiosis, vagus nerve dysfunction, hypothalamic-pituitary-adrenal (HPA) dysregulation, driving neuroinflammation sensitization. Key mechanisms include diversity loss, leaky gut, altered neuroactive signaling via short-chain fatty acids (SCFAs) vagal pathways. This narrative review explores intricate interplay BGA highlighting therapeutic opportunities such restoring modulating activity, regulating endocrine These interventions target inflammation, autonomic balance, stress/reward pathway modulation, offering promising path toward integrative pain management. Further research required to validate these strategies improve patient outcomes.
Язык: Английский
Процитировано
0
Foods, Год журнала: 2025, Номер 14(4), С. 651 - 651
Опубликована: Фев. 14, 2025
Red mold rice, fermented by Monascus spp., has been reported to modulate gut microbiota composition and improve metabolic health. Previous studies indicate that red rice can reduce cholesterol, inhibit hepatic lipid accumulation, enhance bile acid excretion, while also altering under high-fat dietary conditions. However, it remains unclear whether these effects are directly due Monascus-derived products modulating or a consequence of improved health conditions, which indirectly influence microbiota. This study aimed evaluate the pilosus SWM 008 its components-monascin, monascinol, ankaflavin, polysaccharides-on in rats fed normal diet. Over eight weeks, physiological, biochemical, parameters were assessed. Results showed no significant changes body weight liver/kidney function, confirming safety. Gut analysis revealed monascin, polysaccharides significantly altered increasing relative abundance beneficial bacteria, such as Akkermansia muciniphila, Ligilactobacillus murinus, Duncaniella dubosii. Functional predictions indicated enhanced vitamin K2 biosynthesis, nucleotide metabolism, other pathways linked In conclusion, demonstrated safety effects, suggesting potential functional food maintain balance
Язык: Английский
Процитировано
0