Autism spectrum disorders and the gastrointestinal tract: insights into mechanisms and clinical relevance

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 21(3), С. 142 - 163

Опубликована: Дек. 19, 2023

Язык: Английский

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Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?

Nutrients, Год журнала: 2024, Номер 16(4), С. 549 - 549

Опубликована: Фев. 16, 2024

Autism spectrum disorder (ASD) is a neuropsychiatric condition characterized by impaired social interactions and repetitive stereotyped behaviors. Growing evidence highlights an important role of the gut–brain–microbiome axis in pathogenesis ASD. Research indicates abnormal composition gut microbiome potential involvement bacterial molecules neuroinflammation brain development disruptions. Concurrently, attention directed towards short-chain fatty acids (SCFAs) intestinal tightness. This comprehensive review emphasizes impact maternal microbiota changes on autism children, especially considering immune activation (MIA). The following paper evaluates birth route colonization child with bacteria first weeks life. Furthermore, it explores pro-inflammatory cytokines, such as IL-6 IL-17a mother’s obesity potentially environmental factors purpose this to advance our understanding ASD pathogenesis, while also searching for positive implications latest therapies, probiotics, prebiotics or fecal transplantation, targeting reducing inflammation. aims provide valuable insights that could instruct future studies treatments individuals affected

Язык: Английский

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Dietary intake and gastrointestinal symptoms are altered in children with Autism Spectrum Disorder: the relative contribution of autism-linked traits

Nutrition Journal, Год журнала: 2024, Номер 23(1)

Опубликована: Фев. 28, 2024

Abstract Background Dietary and gastrointestinal (GI) problems have been frequently reported in autism spectrum disorder (ASD). However, the relative contributions of autism-linked traits to dietary GI children with ASD are poorly understood. This study firstly compared intake symptoms between typically developing (TDC), then quantified intake, within group. Methods A sample 121 age-matched TDC were eligible for this study. The indicators included food groups intakes, variety, diet quality. symptom severity, restricted repetitive behaviors (RRBs), sensory profiles, mealtime behaviors, their subtypes. Linear mixed-effects models logistic regression used estimate contributions. Results Children had poorer diets fewer vegetables/fruits, less variety food, a higher degree inadequate/unbalanced more severe constipation/total than TDC. Within group, compulsive behavior (a subtype RRBs) taste/smell sensitivity only associated lower vegetables fruit consumption, respectively. Self-injurious was contributing trait food. Limited problems) severity primary secondary contributors inadequate limited unbalanced Notably, significant independent factor symptoms, manifested no Conclusions most important Our findings highlight that could provide largest benefits if they targeted early detection optimal treatment.

Язык: Английский

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A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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Epidrugs in the Therapy of Central Nervous System Disorders: A Way to Drive on?

Cells, Год журнала: 2023, Номер 12(11), С. 1464 - 1464

Опубликована: Май 24, 2023

The polygenic nature of neurological and psychiatric syndromes the significant impact environmental factors on underlying developmental, homeostatic, neuroplastic mechanisms suggest that an efficient therapy for these disorders should be a complex one. Pharmacological interventions with drugs selectively influencing epigenetic landscape (epidrugs) allow one to hit multiple targets, therefore, assumably addressing wide spectrum genetic central nervous system (CNS) disorders. aim this review is understand what fundamental pathological would optimal target epidrugs in treatment or complications. To date, use histone deacetylases DNA methyltransferase inhibitors (HDACis DNMTis) clinic focused neoplasms (mainly glial origin) based cytostatic cytotoxic actions compounds. Preclinical data show besides activity, deacetylases, methyltransferases, bromodomains, ten-eleven translocation (TET) proteins expression neuroimmune inflammation mediators (cytokines pro-apoptotic factors), neurotrophins (brain-derived neurotropic factor (BDNF) nerve growth (NGF)), ion channels, ionotropic receptors, as well pathoproteins (β-amyloid, tau protein, α-synuclein). Based profile activities, may favorable neurodegenerative diseases. For neurodevelopmental disorders, drug addiction, anxiety depression, schizophrenia, epilepsy, contemporary still require further development concerning tuning pharmacological effects, reduction toxicity, protocols. A promising strategy clarify potential targets therapeutic means cure profiling mechanisms, which have evolved upon physiological lifestyle factors, such diet physical exercise, are effective management diseases dementia.

Язык: Английский

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High-fat diet-induced obesity causes intestinal Th17/Treg imbalance that impairs the intestinal barrier and aggravates anxiety-like behavior in mice

International Immunopharmacology, Год журнала: 2024, Номер 130, С. 111783 - 111783

Опубликована: Март 1, 2024

Язык: Английский

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The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period

Frontiers in Neural Circuits, Год журнала: 2022, Номер 16

Опубликована: Ноя. 1, 2022

The prefrontal cortex plays a central role in the control of complex cognitive processes including action and decision making. It also shows specific pattern delayed maturation related to unique behavioral changes during adolescence allows development adult processes. adolescent brain is extremely plastic critically vulnerable external insults. Related this vulnerability, associated with emergence numerous neuropsychiatric disorders involving alterations functions. Within microcircuits, dopamine endocannabinoid systems have widespread effects on adolescent-specific ontogenetic In review, we highlight recent advances our understanding system adolescence. We discuss how they interact GABA glutamate neurons modulate circuits can be altered by different environmental events leading long-term neurobiological at adulthood. Finally, aim identify several future research directions help gaps current knowledge these microcircuits.

Язык: Английский

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Maternal microbiome disturbance induces deficits in the offspring’s behaviors: a systematic review and meta-analysis

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Июль 3, 2023

Recent evidence has suggested that changes in maternal gut microbiota early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether disturbance (MMD) during neurodevelopment might affect offspring adulthood. We found thirteen studies, from set 459 records selected by strategy registered PROSPERO (#289224), target evaluated behavioral outcomes rodents generated dams submitted perinatal enteric perturbation. The analysis revealed significant effect size (SMD = −0.51, 95% CI −0.79 −0.22, p < .001, T2 0.54, I2 79.85%), indicating MMD provoke impairments adult offspring. also induces for reduction sociability behavior −0.63, −1.18 −0.07, 0.011, 0.30, 76.11%) obsessive-compulsive-like −0.68, −0.01 −1.36, 0.009, 0.25, 62.82%) parameters. was not or inconclusive memory anxiety-like behavior, schizophrenia-like depressive-like behavior. experimental vertically transmitted offspring, negatively impacting parameters related psychiatric disorders.

Язык: Английский

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The effect of maternal consumption of high-fat diet on ovarian development in offspring

Animal Reproduction Science, Год журнала: 2023, Номер 255, С. 107294 - 107294

Опубликована: Июль 4, 2023

The environment encountered by the fetus during its development exerts a profound influence on physiological function and disease risk in adulthood. Women's intake of high-fat diet pregnancy lactation has gradually become an issue widespread concern. Maternal will not only cause abnormal neurological metabolic syndrome symptoms offspring, but also affect fertility female offspring. affects expression genes related to follicle growth such as AAT, AFP GDF-9, which reduces number follicles impairs development. Additionally, maternal high fat ovarian health inducing oxidative stress cell apoptosis, collectively can impair reproductive potential Reproductive carries significant importance for both humans animals. Therefore, this review aims describe effect exposure offspring discuss possible mechanisms metabolism

Язык: Английский

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Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment

JAMA Network Open, Год журнала: 2023, Номер 6(8), С. e2330255 - e2330255

Опубликована: Авг. 22, 2023

Maternal suboptimal nutrition and high stress levels are associated with adverse fetal childhood neurodevelopment.

Язык: Английский

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