Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review

BMJ Open, Год журнала: 2024, Номер 14(1), С. e077886 - e077886

Опубликована: Янв. 1, 2024

Post-COVID-19 conditions (PCC) is an umbrella term that encompasses a range of signs, symptoms and present weeks after the acute phase SARS-CoV-2 infection. This systematic literature review summarises heterogeneous methodology used to measure PCC across real-world studies highlights trends by region, age group, follow-up period data source. Methods Medline, EMBASE Cochrane Library were searched supplemented with conference grey searches. Eligible included individuals (1) or (2) positive test COVID-19 diagnosis who followed over time. Included published in English between 1 January 2020 14 November 2022. Findings Of 291 publications included, 175 (60%) confirmed time for 116 (40%) prespecified definition. There was substantial heterogeneity study design, geography, conditions/symptoms assessed their classification duration follow-up. Among using definition, author-defined criteria (51%) more common than recommended major public health organisations (19%). Measurement periods outcomes from date primarily 3 <6 months (39.2%), 6 <12 (27.5%) <3 (22.9%). When classified organ/system, constitutional-related most frequently adult (86%) paediatric (87%) populations. Within constitutional symptoms, fatigue (91.6%) (95.0%) populations, fever/chills (37.9% 55%, respectively). Conclusions definitions are heterogenous studies, which limits reliable comparisons studies. However, some similarities observed terms measured PCC-associated symptoms/conditions, may aid clinical management patients PCC. CRD42022376111.

Язык: Английский

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Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Июль 25, 2024

Abstract Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies PCS. still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding

Язык: Английский

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Outcome predictors of post-COVID conditions in the European Academy of Neurology COVID-19 registry

Journal of Neurology, Год журнала: 2024, Номер 271(6), С. 3153 - 3168

Опубликована: Март 4, 2024

Язык: Английский

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Burden of Neurologic Health Care and Incident Neurologic Diagnoses in the Year After COVID-19 or Influenza Hospitalization

Neurology, Год журнала: 2024, Номер 102(8)

Опубликована: Март 20, 2024

Following the outbreak of viral infections from severe acute respiratory syndrome coronavirus 2 virus in 2019 (coronavirus disease [COVID-19]), reports emerged long-term neurologic sequelae survivors. To better understand burden health care and incident diagnoses year after COVID-19 vs influenza, we performed an analysis patient-level data a large collection electronic records (EMR).

Язык: Английский

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Neurocognitive and Neuropsychiatric Sequelae in Long COVID-19 Infection

Brain Sciences, Год журнала: 2024, Номер 14(6), С. 604 - 604

Опубликована: Июнь 14, 2024

Objective: To characterize the cognitive profile of long COVID-19 subjects and its possible association with clinical symptoms, emotional disturbance, biomarkers, disease severity. Methods: We performed a single-center cross-sectional cohort study. Subjects between 20 60 years old confirmed infection were included. The assessment was 6 months following hospital or ambulatory discharge. Excluded those prior neurocognitive impairment severe neurological/neuropsychiatric disorders. Demographic laboratory data extracted from medical records. Results: Altogether, 108 participants included, 64 male (59.25%), mean age 49.10 years. patients classified into four groups: non-hospitalized (NH, n = 10), hospitalized without Intensive Care Unit (ICU) oxygen therapy (HOSPI, 21), ICU but (OXY, 56), (ICU, 21) patients. In total, 38 (35.18%) reported Subjective Cognitive Complaints (SCC). No differences found considering illness severity groups. Females had more persistent symptoms SCC than males. Persistent dyspnea headache associated higher scores in anxiety depression. fatigue, anxiety, depression worse overall cognition. Conclusions: regarding post-COVID-19 infection. not performance, frequent independent Fatigue, linked to poorer function. Tests for attention, processing speed, executive function most sensitive detecting changes these

Язык: Английский

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Long Neurocognitive and Neuropsychiatric Sequelae in Participants with Post-COVID-19 Infection: A Longitudinal Study

Neurology International, Год журнала: 2024, Номер 16(4), С. 853 - 868

Опубликована: Авг. 16, 2024

Objective: To evaluate and characterize the cognitive changes in COVID-19 participants at 6-month follow-up, to explore a possible association with clinical symptoms, emotional disturbance disease severity. Methods: This single-center longitudinal cohort study included aged 20 60 years old exclude impairment age-associated confirmed infection. The initial evaluation occurred 10 30 days after hospital or ambulatory discharge, subsequent follow-up 6 months. Patients who had history of impairment, neurological conditions, serious psychiatric disorders were not included. Information on demographics laboratory results was gathered from medical records. Cognitive outcomes assessed neuropsychological battery including attention, verbal visual memory, language executive function tests. Results: A total 200 study, 108 completed visit. At comparing means baseline those evaluation, significant overall improvement observed memory subtests (p = 0.001), processing speed 0.028; p 0.016) naming independently severity complaints. Anxiety depression significantly higher groups Subjective Complaints (SCC) compared without < 0.01 for both). Conclusions: Persistent symptoms are common regardless often linked Six months COVID-19, most frequently reported headache, dyspnea, fatigue, complaints, anxiety, depression. No found be associated COVID-19. Overall, psychopathological

Язык: Английский

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COVID-19 Convalescent Plasma Therapy: Long-term Implications

Open Forum Infectious Diseases, Год журнала: 2023, Номер 11(1)

Опубликована: Дек. 28, 2023

The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae severe respiratory syndrome 2 (SARS-CoV-2) infection (PASC) is unknown. CONTAIN-Extend study explores the impact COVID-19 convalescent plasma (CCP) therapy SARS-CoV-2 symptoms and general health 18 months following hospitalization. examined 281 participants from original CONTAIN trial (CONTAIN-RCT, NCT04364737) at post-hospitalization for COVID-19. Symptom surveys, global assessments, biospecimen collection were performed November 2021 to October 2022. Multivariable logistic linear regression estimated associations between randomization arms self-reported Patient-Reported Outcomes Measurement Information System (PROMIS) scores adjusted covariables, including age, sex, race/ethnicity, severity, enrollment quarter sites. There no differences in or PROMIS CCP placebo (adjusted odds ratio [aOR] symptoms, 0.95; 95% CI, 0.54-1.67). However, females (aOR, 3.01; 1.73-5.34), those 45-64 years 2.55; 1.14-6.23), April-June 2020 enrollees 2.39; 1.10-5.19) more likely report have poorer physical than their respective reference groups. Hispanic (difference, -3.05; -5.82 -0.27) Black (-4.48; -7.94 -1.02) had White participants. demonstrated lasting PASC overall comparison placebo. This underscores significance demographic factors, timing infection, influencing symptom reporting after hypoxic

Язык: Английский

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COMPREHENSIVE REVIEW OF POST-COVID-19 INFECTIONS: A MULTIFACETED ANALYSIS

International Journal of Current Pharmaceutical Research, Год журнала: 2023, Номер unknown, С. 43 - 49

Опубликована: Ноя. 15, 2023

This comprehensive review offers a multifaceted analysis of post-COVID-19 infections, encompassing diverse aspects this evolving health concern. In the realm symptomatology, we explore both common and rare symptoms observed in individuals recovering from COVID-19, shedding light on intricacies post-acute sequelae. Moving forward, delve into association between COVID-19 diabetes along with glucose intolerance, analyzing incidence these metabolic conditions post-COVID era. Another critical dimension our is examination potential direct obesity, considering implications relationship public health. Furthermore, trace evolution treatment strategies across pandemic's waves, providing approaches taken during 1st, 2nd, 3rd discussions current government-recommended management protocols. As navigate ongoing challenges presented by conditions, article aims to serve as valuable resource for healthcare professionals, researchers, seeking deeper understanding nature infections their strategies. Concluding remarks, underscores complex landscape ranging symptomatology associations It serves vital efforts.

Язык: Английский

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Definitions and symptoms of the post-COVID syndrome: an updated systematic umbrella review

Опубликована: Апрель 25, 2024

Post-COVID syndrome (PCS) describes a persistent complex of symptoms following COVID-19 episode, lasting at least 4 to 12 weeks, depending on the specific criteria used for its definition. It is often associated with moderate severe impairments daily life and represents major burden many people worldwide. However, especially during first two years pandemic, therapeutic diagnostic uncertainties were prominent due novelty disease non-specific definitions that overlooked functional deficits lacked objective assessment. The present work comprehensively examines status PCS as depicted in recent reviews meta-analyses, alongside exploring impairments. We searched database Pubmed meta-analysis evaluating period between May 31, 2022, December 2023. Out 95 studies, 33 selected inclusion our analyses. Furthermore, we extended upon prior research by systematically recording linked identified studies. found fatigue, neurological complaints, exercise intolerance most frequently reported symptoms. In conclusion, over past eighteen months, there has been notable increase quantity quality studies still remains clear need improvement, particularly regard definition necessary diagnosing this syndrome. Enhancing aspect will render future more comparable precise, thereby advancing understanding PCS.

Язык: Английский

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COVID-19 autism spectrum disorder-like transient neurocognitive clinical presentation

BMJ Case Reports, Год журнала: 2024, Номер 17(9), С. e259782 - e259782

Опубликована: Сен. 1, 2024

The COVID-19 pandemic has impacted the general population in different ways, including vulnerable of children with special needs. In this case report, we will discuss emergence a transient, full-blown picture autism spectrum disorder (ASD) child who contracted infection, and his gradual improvement over course few months. This broadens our perspective on possible neurocognitive clinical presentations infection.

Язык: Английский

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