Investigating the Potential Anti-Alzheimer’s Disease Mechanism of Marine Polyphenols: Insights from Network Pharmacology and Molecular Docking DOI Creative Commons
Kumju Youn, Chi‐Tang Ho, Mira Jun

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(11), С. 580 - 580

Опубликована: Ноя. 6, 2023

Marine polyphenols, including eckol(EK), dieckol(DK), and 8,8'-bieckol(BK), have attracted attention as bioactive ingredients for preventing Alzheimer's disease (AD). Since AD is a multifactorial disorder, the present study aims to provide an unbiased elucidation of unexplored targets mechanisms systematic prediction effective preventive combinations marine polyphenols. Based on omics data between each compound AD, protein-protein interaction (PPI) network was constructed predict potential hub genes. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses were performed further biological insights. In PPI top 10 genes, AKT1, SRC, EGFR, ESR1 common EK BK, whereas PTGS2 target DK BK. GO KEGG analysis revealed that overlapped genes mainly enriched in EGFR tyrosine kinase inhibitor resistance, MAPK pathway, Rap1 Ras pathways. Finally, docking validation showed stable binding polyphenols their gene via lowest energy multiple interactions. The results expanded novel also provided system-level insight into molecular against AD.

Язык: Английский

EGFR-Activated JAK2/STAT3 Pathway Confers Neuroprotection in Spinal Cord Ischemia–Reperfusion Injury: Evidence from High-Throughput Sequencing and Experimental Models DOI

Shijie Lv,

Kunchi Zhao, Ran Li

и другие.

Molecular Neurobiology, Год журнала: 2023, Номер 61(2), С. 646 - 661

Опубликована: Сен. 1, 2023

Язык: Английский

Процитировано

3
Investigating the Potential Anti-Alzheimer’s Disease Mechanism of Marine Polyphenols: Insights from Network Pharmacology and Molecular Docking DOI Creative Commons
Kumju Youn, Chi‐Tang Ho, Mira Jun

и другие.

Marine Drugs, Год журнала: 2023, Номер 21(11), С. 580 - 580

Опубликована: Ноя. 6, 2023

Marine polyphenols, including eckol(EK), dieckol(DK), and 8,8'-bieckol(BK), have attracted attention as bioactive ingredients for preventing Alzheimer's disease (AD). Since AD is a multifactorial disorder, the present study aims to provide an unbiased elucidation of unexplored targets mechanisms systematic prediction effective preventive combinations marine polyphenols. Based on omics data between each compound AD, protein-protein interaction (PPI) network was constructed predict potential hub genes. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses were performed further biological insights. In PPI top 10 genes, AKT1, SRC, EGFR, ESR1 common EK BK, whereas PTGS2 target DK BK. GO KEGG analysis revealed that overlapped genes mainly enriched in EGFR tyrosine kinase inhibitor resistance, MAPK pathway, Rap1 Ras pathways. Finally, docking validation showed stable binding polyphenols their gene via lowest energy multiple interactions. The results expanded novel also provided system-level insight into molecular against AD.

Язык: Английский

Процитировано

3