International Journal of Science and Research Archive,
Год журнала:
2023,
Номер
9(2), С. 920 - 925
Опубликована: Авг. 30, 2023
We
conducted
a
comprehensive
clinical
and
laboratory
study
of
102
preterm
infants
with
hypoxic-ischemic
encephalopathy
(HIE)
varying
gestational
ages.
All
were
born
to
mothers
complicated
obstetric
history.
Clinical
manifestation
CNS
injury
was
observed
in
100%
this
cohort.
Intracranial
hemorrhages
(ICH)
grades
I-IV
registered
38
(37.2%)
cases,
while
periventricular
leukomalacia
(PVL)
present
5
(4.9%)
cases.
Intrauterine
growth
restriction
(IUGR)
36
(35.3%)
respiratory
distress
syndrome
(RDS)
65
(63.7%)
Mild
cerebral
ischemia
diagnosed
51
(50%)
moderate-severity
cases
32
(31.4%)
severe
CI
19
(18.6%)
infants.
The
severity
progression
HIE
shown
be
dependent
on
age,
intrauterine
hypoxia,
birth
asphyxia.
health
status
their
plays
crucial
role
the
development
other
systemic
injuries
Therefore,
premature
births
remain
pertinent
issue
modern
society.
Nursing in Critical Care,
Год журнала:
2025,
Номер
30(2)
Опубликована: Фев. 26, 2025
The
optimal
timing
for
exchanging
an
endotracheal
tube
a
tracheostomy
cannula
in
patients
with
hypoxic-ischaemic
encephalopathy
is
controversial.
This
study
aimed
to
evaluate
the
effects
of
early
versus
late
on
prognosis
encephalopathy.
was
observational
retrospective
that
followed
Strengthening
Reporting
Observational
Studies
Epidemiology
guidelines.
We
included
adults
who
underwent
between
January
2012
and
September
2020.
were
classified
into
or
groups.
To
eliminate
differences
baseline
characteristics,
propensity
score
matching
conducted,
outcomes
two
groups
compared.
A
total
132
included,
through
matching,
54
pairs
matched.
group
showed
significant
reduction
duration
mechanical
ventilation
(median,
12
days;
interquartile
range
7-20
vs.
median,
28
range,
15.75-58.25,
p
<
.001),
intensive
care
unit
length
stay
14.5
6.75-26
35
20-59,
.001)
hospital
19.5
10.87-36.5
39.5
22-66,
.001).
Over
1-year
follow-up
period,
there
no
regarding
inhospital
mortality
(57.4%
46.3%,
=
.248),
30-day
(59.3%
.177)
(61.1%
48.1%,
.176).
In
undergoing
ventilation,
associated
decreased
stay.
For
are
at
high
risk
requiring
prolonged
benefits
suggest
considering
it
viable
treatment
option.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2035 - 2035
Опубликована: Фев. 7, 2024
Hypoxic-ischemic
encephalopathy
(HIE)
is
one
of
the
most
common
causes
childhood
disability.
Hypothermic
therapy
currently
only
approved
neuroprotective
approach.
However,
early
diagnosis
HIE
can
be
challenging,
especially
in
first
hours
after
birth
when
decision
to
use
hypothermic
critical.
Distinguishing
from
other
neonatal
conditions,
such
as
sepsis,
becomes
a
significant
problem
diagnosis.
This
study
explored
utility
metabolomic-based
approach
employing
NeoBase
2
MSMS
kit
diagnose
using
dry
blood
stains
Rice-Vannucci
model
rats.
We
evaluated
diagnostic
fidelity
this
range
between
3
and
6
h
onset
HIE,
including
context
systemic
inflammation
concomitant
therapy.
Discriminant
analysis
revealed
several
metabolite
patterns
associated
with
HIE.
A
logistic
regression
glycine
levels
achieved
high
areas
under
receiver
operating
characteristic
curve
0.94
at
0.96
In
addition,
orthogonal
partial
least
squares
discriminant
analysis,
which
included
five
metabolites,
100%
sensitivity
80%
specificity
within
These
results
highlight
potential
for
could
improve
patient
management
outcomes
serious
illness.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8903 - 8903
Опубликована: Авг. 15, 2024
Hypoxic–ischemic
encephalopathy
(HIE)
is
a
severe
neurological
disorder
caused
by
perinatal
asphyxia
with
significant
consequences.
Early
recognition
and
intervention
are
crucial,
therapeutic
hypothermia
(TH)
being
the
primary
treatment,
but
its
efficacy
depends
on
early
initiation
of
treatment.
Accurately
assessing
HIE
severity
in
neonatal
care
poses
challenges,
omics
approaches
have
made
contribution
to
understanding
complex
pathophysiology.
Our
study
further
explores
impact
blood
metabolome
over
time
investigated
changes
associated
hypothermia’s
effects.
Using
rat
model
hypoxic–ischemic
brain
injury,
we
comprehensively
analyzed
dried
spot
samples
for
fat-soluble
compounds
using
HPLC-MS.
research
shows
after
HIE,
particularly
rapid
recovery
lipid
metabolism
observed.
Significant
metabolites
were
observed
3
h
including
increases
ceramides,
carnitines,
certain
fatty
acids,
phosphocholines,
phosphoethanolamines,
while
sphingomyelins
N-acylethanolamines
(NAEs)
decreased
(p
<
0.05).
Furthermore,
NAEs
found
be
features
OPLS-DA
diagnosis,
an
area
under
curve
0.812.
TH
showed
notable
association
concentrations
ceramides.
Enrichment
analysis
corroborated
these
observations,
showing
modulation
several
key
metabolic
pathways,
arachidonic
acid
oxylipin
metabolism,
eicosanoid
via
lipooxygenases,
leukotriene
C4
synthesis
deficiency.
reveals
dynamic
effects
hypothermia,
which
improves
our
pathophysiology
could
lead
development
new
diagnostic
HIE.
Hypoxic-ischemic
encephalopathy
(HIE)
is
one
of
the
most
common
causes
childhood
disability.
Hypothermic
therapy
currently
only
approved
neuroprotective
approach.
However,
early
diagnosis
HIE
can
be
challenging,
especially
in
first
hours
after
birth
when
decision
to
treat
with
hypothermic
critical.
Differentiating
from
other
neonatal
conditions,
such
as
sepsis,
further
complicates
diagnosis.
This
study
investigated
utility
a
metabolomic-based
approach
using
NeoBase
2
MSMS
kit
diagnose
dry
blood
stains
Rice-Vannucci
model
rats.
We
evaluated
diagnostic
accuracy
this
method
between
3
and
6
onset
HIE,
including
context
systemic
inflammation
concomitant
therapy.
Discriminant
analysis
revealed
several
metabolite
patterns
associated
HIE.
A
logistic
regression
glycine
levels
achieved
high
areas
under
curve
(AUC)
0.94
at
0.96
In
addition,
orthogonal
partial
least
squares
discriminant
analysis,
which
included
five
metabolites,
100%
sensitivity
80%
specificity
within
These
results
highlight
significant
potential
for
could
improve
patient
management
outcomes
serious
illness.
Archives of Medical Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 6, 2024
Introduction
Research
has
established
that
estradiol
(E2)
offers
neuroprotection
against
hypoxic-ischemic
brain
damage
(HIBD)
in
neonatal
rats,
yet
the
underlying
mechanisms
are
not
fully
understood.
This
study
seeks
to
delineate
whether
E2's
neuroprotective
effects
HIBD
mediated
through
astrocytes
by
modulating
G
Protein-Coupled
Estrogen
Receptor
1
(GPER1)
receptor
and
subsequent
AKT
Serine
(AKT)/NF-κB
signaling
cascade.
Material
methods
We
developed
an
vivo
model
rats
primary
cultures
of
subjected
oxygen-glucose
deprivation-reoxygenation
(OGD-R)
as
vitro
model.
E2
GPER1
inhibitor
(G15)
were
administered
according
experimental
design.
Protein
expression
levels
GPER1,
phosphorylated
(p-AKT),
NF-κB
p65,
cleaved-caspase3
examined
using
Western
blot
analysis.
Apoptosis
was
assessed
via
TUNEL
assay,
presence
TNF-α
IL-1β
cell
supernatant
quantified
ELISA.
The
localization
p-AKT
p65
determined
immunofluorescence.
Results
Our
findings
indicate
treatment
significantly
reduced
volume
infarction
astrocyte
apoptosis.
upregulated
while
downregulating
post-HIBD.
Additionally,
diminished
secretion
supernatant.
G15
notably
reversed
associated
molecular
changes.
Conclusions
These
results
suggest
may
exert
with
inhibiting
apoptosis
p-AKT,
NF-κB,
thereby
providing
a
potential
therapeutic
strategy
for
HIBD.