Association of early versus late tracheostomy with prognosis in hypoxic‐ischaemic encephalopathy patients: A propensity‐matched cohort study

Nursing in Critical Care, Год журнала: 2025, Номер 30(2)

Опубликована: Фев. 26, 2025

The optimal timing for exchanging an endotracheal tube a tracheostomy cannula in patients with hypoxic-ischaemic encephalopathy is controversial. This study aimed to evaluate the effects of early versus late on prognosis encephalopathy. was observational retrospective that followed Strengthening Reporting Observational Studies Epidemiology guidelines. We included adults who underwent between January 2012 and September 2020. were classified into or groups. To eliminate differences baseline characteristics, propensity score matching conducted, outcomes two groups compared. A total 132 included, through matching, 54 pairs matched. group showed significant reduction duration mechanical ventilation (median, 12 days; interquartile range 7-20 vs. median, 28 range, 15.75-58.25, p < .001), intensive care unit length stay 14.5 6.75-26 35 20-59, .001) hospital 19.5 10.87-36.5 39.5 22-66, .001). Over 1-year follow-up period, there no regarding inhospital mortality (57.4% 46.3%, = .248), 30-day (59.3% .177) (61.1% 48.1%, .176). In undergoing ventilation, associated decreased stay. For are at high risk requiring prolonged benefits suggest considering it viable treatment option.

Язык: Английский

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Metabolite Biomarkers for Early Ischemic–Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 2035 - 2035

Опубликована: Фев. 7, 2024

Hypoxic-ischemic encephalopathy (HIE) is one of the most common causes childhood disability. Hypothermic therapy currently only approved neuroprotective approach. However, early diagnosis HIE can be challenging, especially in first hours after birth when decision to use hypothermic critical. Distinguishing from other neonatal conditions, such as sepsis, becomes a significant problem diagnosis. This study explored utility metabolomic-based approach employing NeoBase 2 MSMS kit diagnose using dry blood stains Rice-Vannucci model rats. We evaluated diagnostic fidelity this range between 3 and 6 h onset HIE, including context systemic inflammation concomitant therapy. Discriminant analysis revealed several metabolite patterns associated with HIE. A logistic regression glycine levels achieved high areas under receiver operating characteristic curve 0.94 at 0.96 In addition, orthogonal partial least squares discriminant analysis, which included five metabolites, 100% sensitivity 80% specificity within These results highlight potential for could improve patient management outcomes serious illness.

Язык: Английский

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Dried Blood Spot Metabolome Features of Ischemic–Hypoxic Encephalopathy: A Neonatal Rat Model

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8903 - 8903

Опубликована: Авг. 15, 2024

Hypoxic–ischemic encephalopathy (HIE) is a severe neurological disorder caused by perinatal asphyxia with significant consequences. Early recognition and intervention are crucial, therapeutic hypothermia (TH) being the primary treatment, but its efficacy depends on early initiation of treatment. Accurately assessing HIE severity in neonatal care poses challenges, omics approaches have made contribution to understanding complex pathophysiology. Our study further explores impact blood metabolome over time investigated changes associated hypothermia’s effects. Using rat model hypoxic–ischemic brain injury, we comprehensively analyzed dried spot samples for fat-soluble compounds using HPLC-MS. research shows after HIE, particularly rapid recovery lipid metabolism observed. Significant metabolites were observed 3 h including increases ceramides, carnitines, certain fatty acids, phosphocholines, phosphoethanolamines, while sphingomyelins N-acylethanolamines (NAEs) decreased (p < 0.05). Furthermore, NAEs found be features OPLS-DA diagnosis, an area under curve 0.812. TH showed notable association concentrations ceramides. Enrichment analysis corroborated these observations, showing modulation several key metabolic pathways, arachidonic acid oxylipin metabolism, eicosanoid via lipooxygenases, leukotriene C4 synthesis deficiency. reveals dynamic effects hypothermia, which improves our pathophysiology could lead development new diagnostic HIE.

Язык: Английский

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Cerebral palsy in children: A clinical practice review

Current problems in pediatric and adolescent health care, Год журнала: 2024, Номер 54(11), С. 101673 - 101673

Опубликована: Авг. 20, 2024

Язык: Английский

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Alpha-band activity in density spectral array predictive for neurological outcome in patients with hypoxic-ischemic encephalopathy

Clinical Neurology and Neurosurgery, Год журнала: 2025, Номер 250, С. 108791 - 108791

Опубликована: Фев. 21, 2025

Язык: Английский

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PREDICTION OF ADVERSE OUTCOMES IN HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN TERM NEWBORNS

World of Medicine and Biology, Год журнала: 2025, Номер 21(91), С. 90 - 90

Опубликована: Янв. 1, 2025

Язык: Английский

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Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model

Neuroscience Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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Arterial Drug Delivery in the Future: Addressing Complex Problems as Acute Ischemic Stroke

Опубликована: Янв. 1, 2025

Язык: Английский

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Metabolite Biomarkers for Early Ischemic Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model

Опубликована: Дек. 5, 2023

Hypoxic-ischemic encephalopathy (HIE) is one of the most common causes childhood disability. Hypothermic therapy currently only approved neuroprotective approach. However, early diagnosis HIE can be challenging, especially in first hours after birth when decision to treat with hypothermic critical. Differentiating from other neonatal conditions, such as sepsis, further complicates diagnosis. This study investigated utility a metabolomic-based approach using NeoBase 2 MSMS kit diagnose dry blood stains Rice-Vannucci model rats. We evaluated diagnostic accuracy this method between 3 and 6 onset HIE, including context systemic inflammation concomitant therapy. Discriminant analysis revealed several metabolite patterns associated HIE. A logistic regression glycine levels achieved high areas under curve (AUC) 0.94 at 0.96 In addition, orthogonal partial least squares discriminant analysis, which included five metabolites, 100% sensitivity 80% specificity within These results highlight significant potential for could improve patient management outcomes serious illness.

Язык: Английский

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β -estradiol alleviates Hypoxic-ischemic brain damage in neonatal rats through the GPER1 regulating AKT/NF-κB signal pathway

Archives of Medical Science, Год журнала: 2024, Номер unknown

Опубликована: Авг. 6, 2024

Introduction Research has established that estradiol (E2) offers neuroprotection against hypoxic-ischemic brain damage (HIBD) in neonatal rats, yet the underlying mechanisms are not fully understood. This study seeks to delineate whether E2's neuroprotective effects HIBD mediated through astrocytes by modulating G Protein-Coupled Estrogen Receptor 1 (GPER1) receptor and subsequent AKT Serine (AKT)/NF-κB signaling cascade. Material methods We developed an vivo model rats primary cultures of subjected oxygen-glucose deprivation-reoxygenation (OGD-R) as vitro model. E2 GPER1 inhibitor (G15) were administered according experimental design. Protein expression levels GPER1, phosphorylated (p-AKT), NF-κB p65, cleaved-caspase3 examined using Western blot analysis. Apoptosis was assessed via TUNEL assay, presence TNF-α IL-1β cell supernatant quantified ELISA. The localization p-AKT p65 determined immunofluorescence. Results Our findings indicate treatment significantly reduced volume infarction astrocyte apoptosis. upregulated while downregulating post-HIBD. Additionally, diminished secretion supernatant. G15 notably reversed associated molecular changes. Conclusions These results suggest may exert with inhibiting apoptosis p-AKT, NF-κB, thereby providing a potential therapeutic strategy for HIBD.

Язык: Английский

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