Clinical and laboratory study of premature infants with hypoxic-ischemic encephalopathy DOI Creative Commons

Gurbanova Jamila,

Ali-zade Samaya,

Asadova Tarana

et al.

International Journal of Science and Research Archive, Journal Year: 2023, Volume and Issue: 9(2), P. 920 - 925

Published: Aug. 30, 2023

We conducted a comprehensive clinical and laboratory study of 102 preterm infants with hypoxic-ischemic encephalopathy (HIE) varying gestational ages. All were born to mothers complicated obstetric history. Clinical manifestation CNS injury was observed in 100% this cohort. Intracranial hemorrhages (ICH) grades I-IV registered 38 (37.2%) cases, while periventricular leukomalacia (PVL) present 5 (4.9%) cases. Intrauterine growth restriction (IUGR) 36 (35.3%) respiratory distress syndrome (RDS) 65 (63.7%) Mild cerebral ischemia diagnosed 51 (50%) moderate-severity cases 32 (31.4%) severe CI 19 (18.6%) infants. The severity progression HIE shown be dependent on age, intrauterine hypoxia, birth asphyxia. health status their plays crucial role the development other systemic injuries Therefore, premature births remain pertinent issue modern society.

Language: Английский

Association of early versus late tracheostomy with prognosis in hypoxic‐ischaemic encephalopathy patients: A propensity‐matched cohort study DOI Creative Commons

Y.P. Li,

Dingyuan Wan, Hongmei Liu

et al.

Nursing in Critical Care, Journal Year: 2025, Volume and Issue: 30(2)

Published: Feb. 26, 2025

The optimal timing for exchanging an endotracheal tube a tracheostomy cannula in patients with hypoxic-ischaemic encephalopathy is controversial. This study aimed to evaluate the effects of early versus late on prognosis encephalopathy. was observational retrospective that followed Strengthening Reporting Observational Studies Epidemiology guidelines. We included adults who underwent between January 2012 and September 2020. were classified into or groups. To eliminate differences baseline characteristics, propensity score matching conducted, outcomes two groups compared. A total 132 included, through matching, 54 pairs matched. group showed significant reduction duration mechanical ventilation (median, 12 days; interquartile range 7-20 vs. median, 28 range, 15.75-58.25, p < .001), intensive care unit length stay 14.5 6.75-26 35 20-59, .001) hospital 19.5 10.87-36.5 39.5 22-66, .001). Over 1-year follow-up period, there no regarding inhospital mortality (57.4% 46.3%, = .248), 30-day (59.3% .177) (61.1% 48.1%, .176). In undergoing ventilation, associated decreased stay. For are at high risk requiring prolonged benefits suggest considering it viable treatment option.

Language: Английский

Citations

1
Metabolite Biomarkers for Early Ischemic–Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model DOI Open Access

Yulia Shevtsova,

Natalia Starodubtseva, Alisa Tokareva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2035 - 2035

Published: Feb. 7, 2024

Hypoxic-ischemic encephalopathy (HIE) is one of the most common causes childhood disability. Hypothermic therapy currently only approved neuroprotective approach. However, early diagnosis HIE can be challenging, especially in first hours after birth when decision to use hypothermic critical. Distinguishing from other neonatal conditions, such as sepsis, becomes a significant problem diagnosis. This study explored utility metabolomic-based approach employing NeoBase 2 MSMS kit diagnose using dry blood stains Rice-Vannucci model rats. We evaluated diagnostic fidelity this range between 3 and 6 h onset HIE, including context systemic inflammation concomitant therapy. Discriminant analysis revealed several metabolite patterns associated with HIE. A logistic regression glycine levels achieved high areas under receiver operating characteristic curve 0.94 at 0.96 In addition, orthogonal partial least squares discriminant analysis, which included five metabolites, 100% sensitivity 80% specificity within These results highlight potential for could improve patient management outcomes serious illness.

Language: Английский

Citations

4
Neural Responses to Hypoxic Injury in a Vascularized Cerebral Organoid Model DOI Creative Commons
Yang Li,

Xin-Yao Sun,

Peng-Ming Zeng

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Cerebral palsy in children: A clinical practice review DOI
Dilip R. Patel, Karen Bovid,

Rebecca Rausch

et al.

Current problems in pediatric and adolescent health care, Journal Year: 2024, Volume and Issue: 54(11), P. 101673 - 101673

Published: Aug. 20, 2024

Language: Английский

Citations

3
Alpha-band activity in density spectral array predictive for neurological outcome in patients with hypoxic-ischemic encephalopathy DOI

Narumi Ohno,

Shuichiro Neshige, Megumi Nonaka

et al.

Clinical Neurology and Neurosurgery, Journal Year: 2025, Volume and Issue: 250, P. 108791 - 108791

Published: Feb. 21, 2025

Language: Английский

Citations

0
PREDICTION OF ADVERSE OUTCOMES IN HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN TERM NEWBORNS DOI

L.R. Rahimova

World of Medicine and Biology, Journal Year: 2025, Volume and Issue: 21(91), P. 90 - 90

Published: Jan. 1, 2025

Language: Английский

Citations

0
Arterial Drug Delivery in the Future: Addressing Complex Problems as Acute Ischemic Stroke DOI

Shailendra Joshi,

Alexander Ramos

Published: Jan. 1, 2025

Language: Английский

Citations

0
Dried Blood Spot Metabolome Features of Ischemic–Hypoxic Encephalopathy: A Neonatal Rat Model DOI Open Access

Chupalav Eldarov,

Natalia Starodubtseva,

Yulia Shevtsova

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8903 - 8903

Published: Aug. 15, 2024

Hypoxic–ischemic encephalopathy (HIE) is a severe neurological disorder caused by perinatal asphyxia with significant consequences. Early recognition and intervention are crucial, therapeutic hypothermia (TH) being the primary treatment, but its efficacy depends on early initiation of treatment. Accurately assessing HIE severity in neonatal care poses challenges, omics approaches have made contribution to understanding complex pathophysiology. Our study further explores impact blood metabolome over time investigated changes associated hypothermia’s effects. Using rat model hypoxic–ischemic brain injury, we comprehensively analyzed dried spot samples for fat-soluble compounds using HPLC-MS. research shows after HIE, particularly rapid recovery lipid metabolism observed. Significant metabolites were observed 3 h including increases ceramides, carnitines, certain fatty acids, phosphocholines, phosphoethanolamines, while sphingomyelins N-acylethanolamines (NAEs) decreased (p < 0.05). Furthermore, NAEs found be features OPLS-DA diagnosis, an area under curve 0.812. TH showed notable association concentrations ceramides. Enrichment analysis corroborated these observations, showing modulation several key metabolic pathways, arachidonic acid oxylipin metabolism, eicosanoid via lipooxygenases, leukotriene C4 synthesis deficiency. reveals dynamic effects hypothermia, which improves our pathophysiology could lead development new diagnostic HIE.

Language: Английский

Citations

3
Therapeutic Hypothermia and Its Role in Preserving Brain Volume in Term Neonates with Perinatal Asphyxia DOI Open Access
Hernán Felipe García Arias, Gloria Liliana Porras-Hurtado, Jorge Mario Estrada-Álvarez

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7121 - 7121

Published: Nov. 25, 2024

Perinatal asphyxia is a major cause of neonatal morbidity and mortality, often resulting in hypoxic-ischemic encephalopathy (HIE) with long-term neurodevelopmental impairments. While therapeutic hypothermia has emerged as promising intervention to reduce brain damage, its specific impact on key structures outcomes remains underexplored. This study aims evaluate the effects volumetry, cortical thickness, neurodevelopment term neonates perinatal asphyxia.

Language: Английский

Citations

0
Assessment of the effect of hypothermia after simulated hypoxic ischemic encephalopathy based on blood metabolome DOI Creative Commons

CM El'darov,

Natalia Starodubtseva,

Yulia A. Shevtsova

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Hypoxic ischemic encephalopathy (HIE) is a severe neonatal condition causing various neurological disorders and one of the main causes mortality among full-term babies. Therapeutic hypothermia (TH), i.e. newborn’s body temperature decrease that significantly reduces risk fatality contributes to improvement long-term outcomes in infants with HIE key treatment method for moderate-to-severe HIE. However, timely diagnosis disease severity determination are crucial this be used, has number limitations requirements. Assessment mechanism underlying effects TH search major metabolic pathways potential targets therapy relevant. The study aimed assess metabolome dried blood spots by HPLC-MS, since it least invasive patients test markers most active likely mediate its positive effects. As result, alterations class phosphoglycerolipids were found, which suggests an important role endocannabinoid metabolism protection against Furthermore, ubiquinone, certain fatty acids, bile acids altered. targeted quantitative studies these metabolites will make possible optimize based on identified.

Language: Английский

Citations

0