Psychedelic-Induced Neural Plasticity: A Comprehensive Review and a Discussion of Clinical Implications

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 117 - 117

Опубликована: Янв. 25, 2025

Background: Psychedelics are increasingly recognized as a promising and innovative treatment strategy for several mental disorders. However, there is still lively controversy in the medical community regards rationale of their employment, specifically indications potential dangers. Methods: A comprehensive literature search on “MEDLINE/PubMed” “Web Science” was performed from inception to 26 June 2024, cross-checking obtained references. We included all studies, i.e., both clinical preclinical, that supplied original data. Results: initially total 1083 entries, 813 MEDLINE/PubMed 270 Web Science. After duplicate elimination, 903 underwent systematic selection. Primary abstract screening yielded 572 candidates eligibility assessment excluded 331 entries formal grounds. Eligibility led exclusion 501 titles. Finally, 70 articles were this review. Discussion: Preclinical evidence genetic expression, histology behavioral studies soundly consistent with psychedelics possessing neuroplasticity-inducing properties. Despite methodological difficulties, seems be inferentially agreement preclinical findings. it unclear whether “neuroplastic boost” induced by classic might dissociable psychodysleptic effects, thereby reducing psychopathological hazards implied these compounds. Moreover, fact so-called “relaxation priors” should unconditionally beneficial appears debatable, further research clarify possible contraindications psychedelic psychoplastogens within precision medicine perspective.

Язык: Английский

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The Emergence of Psilocybin in Psychiatry and Neuroscience

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 555 - 555

Опубликована: Апрель 9, 2025

Psilocybin, a naturally occurring psychedelic compound, has garnered renewed scientific interest for its potential in treating psychiatric and neurological disorders. This review systematically examines the latest research on psilocybin’s pharmacokinetics, pharmacodynamics, clinical efficacy, safety profile. Emerging evidence supports efficacy conditions such as major depressive disorder (MDD), treatment-resistant depression (TRD), anxiety, alcohol use disorders (AUD), cancer-related distress. Despite promising outcomes, significant barriers remain, including methodological constraints, regulatory hurdles, limited population diversity trials. Advances biosynthetic production optimized psychotherapeutic integration are necessary to ensure scalability accessibility. Future should focus long-term safety, dosing precision, neurobiological mechanisms refine therapeutic applications. provides critical foundation advancing evidence-based of psilocybin.

Язык: Английский

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The effect of psychedelic microdosing on animal behavior: a review with recommendations for the field

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер 174, С. 106204 - 106204

Опубликована: Май 9, 2025

Язык: Английский

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Neurobiology of the Antidepressant Effects of Serotonergic Psychedelics: A Narrative Review

Current Treatment Options in Psychiatry, Год журнала: 2024, Номер 11(2), С. 90 - 105

Опубликована: Апрель 26, 2024

Язык: Английский

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Psilocybin has a narrow therapeutic window as an antidepressant treatment

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111368 - 111368

Опубликована: Апрель 1, 2025

Язык: Английский

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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 1, 2025

Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. This the first study to use MRI follow functional changes in brain activity response different doses of psilocybin fully awake, drug naive rats. We hypothesized that would show dose-dependent increase prefrontal cortex thalamus, while decreasing hippocampal activity. Female male rats were given IP injections vehicle or 0.03 mg/kg, 0.3 3.0 mg/kg awake during imaging session. These levels validated by measuring its metabolite, psilocin. Changes BOLD signal recorded over 20 min window. Data for resting state connectivity collected approximately 35 post injection. All data registered rat 3D atlas 169 areas providing site-specific global connectivity. Treatment resulted significant positive signal. The most affected acute presentation somatosensory cortex, basal ganglia thalamus. Males females showed sensitivity dose, exhibiting greater activation than males at especially thalamic regions. There was connectivity, highlighted hyperconnectivity cerebellum. Brain be involved loss sensory filtering organization motor stimuli, such as cortico-striato-thalamo-cortical circuit claustrum, increased higher psilocybin. Indeed, general neuroanatomical circuitry associated psychedelic experience but direction pattern between neural networks inconsistent human literature.

Язык: Английский

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Psilocybin as a lead candidate molecule in preclinical therapeutic studies of psychiatric disorders: A systematic review

Journal of Neurochemistry, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 29, 2023

Abstract Psilocybin is the main psychoactive compound found in hallucinogenic/magic mushrooms and can bind to both serotonergic tropomyosin receptor kinase b (TrkB) receptors. has begun show efficacy for a range of neuropsychiatric conditions, including treatment‐resistant depression anxiety disorders; however, neurobiological mechanisms are still being elucidated. Clinical research that psilocybin alter functional connectivity patterns human brains, which often associated with therapeutic outcomes. However, preclinical affords opportunity assess potential cellular by may exert its effects. Preclinical rodent models also facilitate more tightly controlled experimental context minimise placebo Furthermore, where there rationale, researchers investigate administration conditions have not yet been researched clinically. As result, we systematically reviewed knowledge base, identifying 82 studies were screened based on specific criteria. This resulted exclusion 44 articles, 34 articles included review another 2 as Supporting Information materials. We shows promise lead candidate molecule treating variety albeit showing most depression. discuss findings, identify possible whereby could invoke changes. critically evaluate between‐study heterogeneity future avenues. Our suggests provide valid translatable tools researching novel psilocybin‐induced molecular mechanisms,

Язык: Английский

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Psilocybin reduces alcohol self-administration via selective left nucleus accumbens activation in rats

Brain, Год журнала: 2024, Номер 147(11), С. 3780 - 3788

Опубликована: Апрель 30, 2024

Abstract The use of psilocybin to treat alcohol disorder is very promising, but its mechanisms action remain poorly understood. We combined behavioural, pharmacological and gene expression analyses decipher the psilocybin, for first time, when injected into brain. Male Long Evans rats underwent chronic operant ethanol self-administration before testing effect intraperitoneal or directly within nucleus accumbens core ventral tegmental area. Transcripts from dopaminergic system were quantified in prefrontal cortex. Psilocybin significantly reduced (by 50%) 4 h session either intraperitoneally (1 mg/kg) left (0.15 μg) not right injection was prevented by intra-left 0.3 μg 5-HT2A receptor antagonist ketanserin. In that self-administered those self-administering saccharin, dopamine D2 (D2R) mRNA increased both cortex while D1 only As humans, through accumbens, possibly D2R expression. Our results open unexpected perspectives regarding hemispheric lateralization psychedelic effects.

Язык: Английский

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Psilocybin decreases neural responsiveness and increases functional connectivity while preserving pure-tone frequency selectivity in mouse auditory cortex

Journal of Neurophysiology, Год журнала: 2024, Номер 132(1), С. 45 - 53

Опубликована: Май 29, 2024

Recent studies have shown promising therapeutic potential for psychedelics in treating neuropsychiatric conditions. Musical experience during psilocybin-assisted therapy is predictive of treatment outcome, yet little known about how psilocybin affects auditory processing. Here, we conducted two-photon imaging experiments cortex awake mice that received a dose psilocybin. Our results suggest modulates the roles intrinsic neural activity versus stimulus-driven influences on perception.

Язык: Английский

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Effects of serotonergic psychedelics on synaptogenesis and immediate early genes expression - comparison with ketamine, fluoxetine and lithium

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

Background: Recent evidence suggests that psychedelics are able to induce rapid and long-lasting antidepressant effects. The generally acknowledged explanation for these traits is the phenomenon of neuroplasticity, although exact underlying molecular mechanisms remain unclear. Aims: This study investigates selected neuroplastic effects psilocin, lysergic acid diethylamide (LSD) N,N-dimethyltryptamine (DMT) in direct comparison with ketamine, fluoxetine lithium after acute (1 h) and/or prolonged (24 treatment vitro. Methods: Rat primary cortical cultures were treated 10 uM 1 (LSD), 90 N, N-dimethyltryptamine (DMT), 5 mM lithium. Analysis synaptic puncta was performed; presynaptic marker synapsin I/II, postsynaptic density protein 95 (PSD-95), their co-localization (established synapse) assessed 24 h drug treatment. Next, expressions immediate early genes (IEGs) encoding activity-regulated cytoskeleton-associated (Arc), growth response (Egr1), neuronal PAS (Per-ArntSim) domain 4 (Npas4) analysed treatments. Results: Psilocin increased count induced Arc expression. effect promote synaptogenesis comparable ketamine lithium; additionally PSD-95 count. LSD DMT didn't any significant effect. Interestingly, had no on count, but upregulated Egr1 Npas4. Conclusions: demonstrated a lithium, adding another piece its profile as promising therapeutic agent.

Язык: Английский

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