Опубликована: Янв. 1, 2024
Язык: Английский
Cells, Год журнала: 2024, Номер 13(6), С. 474 - 474
Опубликована: Март 7, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.
Язык: Английский
Процитировано
11
Опубликована: Янв. 31, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal losss and progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration, involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells specifically their pathology treatment.
Язык: Английский
Процитировано
5
Phytotherapy Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 11, 2024
With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive
Язык: Английский
Процитировано
5
Pharmacological Research, Год журнала: 2023, Номер 197, С. 106975 - 106975
Опубликована: Окт. 29, 2023
Nicotinic acetylcholine receptors (nAChRs) belong to a superfamily of cys-loop characterized by the assembly five subunits into multi-protein channel complex. Ligand binding nAChRs activates rapid allosteric transitions receptor leading opening and ion flux in neuronal non-neuronal cell. Thus, while ionotropic properties are well recognized, less is known about ligand-mediated intracellular "metabotropic" signaling nAChRs. Studies neural non-neural cells confirm that metabotropic responses observable following ligand binding. In this review we summarize evidence on existence homopentameric α7 various cell types. We explore how coordinated calcium entry through release from nearby stores gives rise important for modulation cytoskeletal motility growth. Amino acid residues for, protein within human nAChR support engagement including heterotrimeric G proteins immune cells. Understanding dual likely essential advancing drug development other mechanistic treatments disease.
Язык: Английский
Процитировано
12
Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1634 - 1634
Опубликована: Фев. 14, 2025
Aging and age-related neurodegenerative disorders are characterized by the dysfunction or loss of brain nicotinic acetylcholine receptors (nAChRs), these changes may be related to other senescence markers, such as oxidative stress DNA repair dysfunction. However, mechanism nAChR in aging modification this process drugs (e.g., memantine, Mem) not yet fully understood. To study whether differences expression rat occur due modulated Mem, we analyzed subunits (at RNA protein levels) biomarkers real-time quantitative polymerase chain reaction (RQ-PCR) Western blot validation. Twenty-one female Wistar rats were divided into four groups, depending on age, oldest group received injections Mem water with use intragastric catheters. We studied cerebral grey matter (CGM), subcortical white (SCWM), cerebellum (Ce). Results showed an decrease α7 mRNA level SCWM. The was accompanied reduced 8-oxoguanine glycosylase 1 (OGG1) increased tumor necrosis factor alpha (TNFα) level. In group, observed a higher SCWM Ce. Biomarker levels changed, but different extent area. Importantly, antioxidative status stopped even regressed under treatment. After two weeks treatment, increase TP53 8-oxo-2'deoxyguanosine (8-oxo-2'dG) observed. conclude that administration protective against mechanisms.
Язык: Английский
Процитировано
0
Brain Research Bulletin, Год журнала: 2025, Номер 224, С. 111299 - 111299
Опубликована: Март 12, 2025
Delirium is a complex medical condition marked by acute episodes of cognitive dysfunction and behavioral disturbances, with multifaceted etiology challenging management across various clinical settings. Older adults, particularly in postoperative contexts, are at increased risk developing delirium. Despite extensive research, single underlying pathophysiological mechanism for delirium remains elusive. However, emerging evidence suggests correlation between lipid dysregulation development elderly patients, especially This connection has led to proposed treatments targeting dyslipidemia associated neuroinflammatory effects acute-phase review aims synthesize current literature on the relationship older highlighting need further research into specific neurolipidome constituents age-related profile changes, potentially uncovering novel therapeutic strategies
Язык: Английский
Процитировано
0
Frontiers in Integrative Neuroscience, Год журнала: 2025, Номер 19
Опубликована: Апрель 9, 2025
Arecoline, a biologically active alkaloid extracted from the areca nut, serves as primary psychoactive ingredient in betel quid, one of most widely consumed substances worldwide. Despite its extensive use, central nervous system (CNS) effects arecoline remain inadequately understood. This study aims to investigate actions through comprehensive, multi-dimensional approach that integrates behavioral assays, neuroimaging techniques, calcium signaling analysis, and transcriptomic profiling. Our findings demonstrate dose-dependent addictive properties arecoline, alongside distinct alterations highlight potential for addiction. Neuroimaging data revealed region-specific neural activity, particularly areas associated with learning, memory, reward processing. Furthermore, analysis identified significant changes gene expression, pathways related synaptic plasticity, signaling, metal ion transport. These results provide valuable insights into underlying neurobiological mechanisms, offering crucial information understanding broader impact on CNS function. The study's hold implications informing public health strategies aimed at addressing misuse role addiction-related disorders.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Май 2, 2025
Neurologic and neuropsychiatric disorders are complex, with common pathophysiological mechanisms associated inflammation, oxidative stress, vascular damage. These shared features have stimulated interest in bioactive compounds neuropharmacological potential. In this regard, the 1-Nitro-2-Phenylethane (1N2PE) emerges as a promissory compound to act on multiple via of brain disturbances. However, its action remain largely unknown. We aim provide comprehensive overview scarce literature effects 1N2PE highlight importance further research into potential applications field neurology psychiatry, focusing anti-inflammatory antioxidant properties. The exhibits neuroprotective properties, including anti-inflammatory, antioxidant, cholinergic-enhancing effects, which together may underlie therapeutic benefits for various neurological disorders, such depression, anxiety, seizures, cognitive impairments. This review compiles central nervous system activities, highlighting treating behavioral disorders. Despite promising findings, is essential fully understand novel agent.
Язык: Английский
Процитировано
0
Опубликована: Март 4, 2024
Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss and progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration, involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells specifically their pathology treatment.
Язык: Английский
Процитировано
1