The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis DOI Creative Commons
Alejandro Borrego-Ruiz, Juan J. Borrego

Life, Год журнала: 2025, Номер 15(6), С. 834 - 834

Опубликована: Май 22, 2025

Specific gut microorganisms and their metabolic by-products have been identified as key regulators of host physiology, contributing to the modulation immune system, inflammatory processes, brain function, behavior, which highlights microbiome a potential modulator neurobiological mechanisms involved in substance use disorders. This narrative review provides an updated overview how drugs abuse influence composition dynamics human bacterial dysbiosis may be factor disorders by modulating communication between brain. Thus, examining commonly abused substances such alcohol, psychostimulants, opioids, cannabinoids, nicotine, this aimed deepen understanding bidirectional relationship use. There is evidence indicating that alterations addiction through changes gut-brain signaling. Furthermore, its metabolites not only result from disorders, but could also modulate behavioral responses abuse. Although exact modulates are fully understood, microbial products short-chain fatty acids, tryptophan metabolites, bile neurotransmitters suggested play role process influencing blood–brain barrier permeability, activation, neural signaling, gene expression. Therefore, manipulating or represent promising approach for enhancing disorder treatments, identifying individuals at increased risk pathological drug use, elucidating substance-related behaviors.

Язык: Английский

Evolution and the critical role of the microbiota in the reduced mental and physical health associated with low socioeconomic status (SES) DOI
G.A.W. Rook

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 161, С. 105653 - 105653

Опубликована: Апрель 4, 2024

Язык: Английский

Процитировано

5
Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis DOI Creative Commons
Qi Song,

Youkang Zhu,

Xiao Liu

и другие.

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 28, 2024

Sarcopenia, an age-related disease, has become a major public health concern, threatening muscle and daily functioning in older adults around the world. Changes gut microbiota can affect skeletal metabolism, but exact association is unclear. The richness of refers to number different species sample, while diversity not only considers also evenness their abundances. Alpha comprehensive metric that measures both (richness) abundances, thereby providing thorough understanding composition structure community.

Язык: Английский

Процитировано

5
The Gut Microbiome-Neuroglia Axis: Implications for Brain Health, Inflammation, and Disease DOI Creative Commons
Josué Camberos-Barraza, Alma Marlene Guadrón‐Llanos, Alberto K. De la Herrán-Arita

и другие.

Neuroglia, Год журнала: 2024, Номер 5(3), С. 254 - 273

Опубликована: Авг. 1, 2024

The human central nervous system is convolutedly connected to the gut microbiome, a diverse community of microorganisms residing in gastrointestinal tract. Recent research has highlighted bidirectional communication between microbiome and neuroglial cells, which include astrocytes, microglia, oligodendrocytes, ependymal cells. These cells are essential for maintaining CNS homeostasis, supporting neuronal function, responding pathological conditions. This review examines interactions neuroglia, emphasizing their critical roles brain health development neurological disorders. Dysbiosis, or imbalance been associated with various psychiatric conditions, such as autism spectrum disorder, anxiety, depression, neurodegenerative diseases like Alzheimer’s Parkinson’s. influences function through microbial metabolites, immune modulation, neuroinflammatory responses. Understanding these paves way new therapeutic targets strategies preventing treating scoping aims highlight mechanisms microbiome-neuroglia axis its potential target.

Язык: Английский

Процитировано

5
Postbiotics as Adjuvant Therapy in Cancer Care DOI Open Access
Vyshnavy Balendra, Roberto Rosenfeld, Chiara Amoroso

и другие.

Nutrients, Год журнала: 2024, Номер 16(15), С. 2400 - 2400

Опубликована: Июль 24, 2024

Postbiotics are defined as a preparation of inanimate microorganisms and/or their components that confers health benefit to the host. They range from cell wall fragments metabolites, bacterial lysates, extracellular vesicles, and short-chain fatty acids (SCFAs). may influence carcinogenesis via variety mechanisms. can promote homeostatic immune responses, reduce inflammation, induce selective cytotoxicity against tumor cells, well enabling control proliferation enhancing intestinal epithelial barrier function. Therefore, probiotics serve an adjunct strategy in anticancer treatment together with chemotherapy immunotherapy. Up now, only relevant postbiotics used interventions oncological patients remain vitamin K molecules, few phase-II III trials available. In fact, postbiotics’ levels strictly dependent on gut microbiota’s composition, which vary between individuals be altered under different physiological pathological conditions. lack consistent clinical evidence supporting efficacy is due poor bioavailability, short half-life, fluctuating levels. Synbiotics, mixture prebiotics probiotics, expected have more homogeneous bioavailability respect greater potential for future development. this review, we focus role adjuvant therapy cancer treatment.

Язык: Английский

Процитировано

3
Fecal metabolomic analysis of the role of gut microbiota and short-chain fatty acids in the therapeutic mechanism of Timosaponin AIII in Sjögren’s syndrome DOI Creative Commons
Fengtao Pang, Quan Jiang, Xiaopo Tang

и другие.

Clinical Rheumatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 18, 2025

Язык: Английский

Процитировано

0
Differential Analysis of Fecal SCFAs and Their Contribution to Adipogenesis in UCP1 Knock-In Pigs DOI Creative Commons
Chao-Yang Zhao, Jianfei Pan, Yanfang Wang

и другие.

Veterinary Sciences, Год журнала: 2025, Номер 12(2), С. 102 - 102

Опубликована: Фев. 1, 2025

This study aimed to investigate the changes in fecal short-chain fatty acids (SCFAs) content UCP1 knock-in pigs (KI pigs) and their effect on adipogenesis. Fecal samples from five 6-month-old wild-type (WT) KI were collected for targeted metabolomics 16s rRNA sequencing analyses identify differences SCFAs gut microbiota that may contribute regulating fat deposition pigs. The metabolome of pig an analysis identified seven SCFAs, with caproic acid (except isovaleric acid) being significantly different one. results demonstrated a notable reduction abundance Streptococcus spp. comparison WT pigs, statistically significant difference. Correlation positive correlation between as well body weight fatness. It was postulated intestinal tracts be associated abundance. Compared concentration reduced, which related decreased Streptococcus. vitro experiments showed could enhance differentiation efficiency porcine SVF cells into mature adipocytes by activating FFAR4 gene.

Язык: Английский

Процитировано

0
The brain-gut axis and chronic pain: mechanisms and therapeutic opportunities DOI Creative Commons

Tsz-Ki Ho,

Ömer Elma, Lucy Kocanda

и другие.

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Фев. 14, 2025

The brain-gut axis (BGA) is emerging as a critical mediator in chronic pain, involving bidirectional communication between the central nervous system and gastrointestinal system. “Pain Matrix” associated with microbial dysbiosis, vagus nerve dysfunction, hypothalamic-pituitary-adrenal (HPA) dysregulation, driving neuroinflammation sensitization. Key mechanisms include diversity loss, leaky gut, altered neuroactive signaling via short-chain fatty acids (SCFAs) vagal pathways. This narrative review explores intricate interplay BGA highlighting therapeutic opportunities such restoring modulating activity, regulating endocrine These interventions target inflammation, autonomic balance, stress/reward pathway modulation, offering promising path toward integrative pain management. Further research required to validate these strategies improve patient outcomes.

Язык: Английский

Процитировано

0
Polysaccharides Extracted from Old Stalks of Asparagus officinalis L. Improve Nonalcoholic Fatty Liver by Increasing the Gut Butyric Acid Content and Improving Gut Barrier Function DOI
Wenlong Sun,

Jinghan Jia,

Guangpeng Liu

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Nonalcoholic fatty liver disease (NAFLD) ranks among the most prevalent chronic diseases worldwide, yet effective treatments remain scarce. Old stalks of Asparagus officinalis L. are rich in polysaccharides. The anti-NAFLD mechanism polysaccharides from old A. (AP) requires further study. Here, we studied effects AP on NAFLD mice and its impact gut microbiota. intervention reduces blood lipids injury inflammation with NAFLD. Moreover, changed microbiota composition increased abundances butyric acid-producing bacteria, thereby increasing plasma concentration acid. Furthermore, regulated AMPK/SREBPs signaling pathway, affecting hepatic lipid synthesis. Additionally, improved barrier function reduced LPS levels, which subsequently inhibited LPS/TLR4/NF-κB alleviating model mice. Importantly, fecal transplant (FMT) outcomes demonstrated that AP-induced changes pathways. These data suggest ameliorates by regulating research provides a scientific foundation for use treatment

Язык: Английский

Процитировано

0
Nutritional Interventions in Amyotrophic Lateral Sclerosis: From Ketogenic Diet and Neuroprotective Nutrients to the Microbiota-Gut-Brain Axis Regulation DOI

Samira Nabakhteh,

Amir Lotfi,

Arman Afsartaha

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Язык: Английский

Процитировано

0
Multi-omics approach identifies gut microbiota variations associated with depression DOI Creative Commons
Adrián Hernández-Cacho, Jesús García‐Gavilán, Alessandro Atzeni

и другие.

npj Biofilms and Microbiomes, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 28, 2025

The gut microbiota plays a potential role in the pathophysiology of depression through gut-brain axis. This cross-sectional study 400 participants from PREDIMED-Plus investigates interplay between and using multi-omics approach. Depression was defined as antidepressant use or high Beck Inventory-II scores. Gut characterized by 16S rRNA sequencing, faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with exhibited significant differences microbial composition metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, benzenoids, some which correlated features. highlights depression, paving way for future research to determine whether influences reflects changes associated depression.

Язык: Английский

Процитировано

0