Exploring faradaic and non-faradaic electrochemical impedance spectroscopy approaches in Parkinson's disease diagnosis

Heliyon, Год журнала: 2024, Номер 10(5), С. e27433 - e27433

Опубликована: Март 1, 2024

Parkinson's disease is a neurodegenerative condition defined by the progressive death of dopaminergic neurons in brain. The diagnosis often uses time-consuming clinical evaluations and subjective assessments. Electrochemical Impedance Spectroscopy (EIS) useful technique for electroanalytical devices due to its label-free performance, in-situ measurements, low cost. development reliable diagnostic tools can be significantly enhanced exploring novel techniques like faradaic non-faradaic EIS detection methods. These have ability identify specific biomarkers or changes electrochemical properties linked disease, allowing an early accurate diagnosis. Faradaic methods utilize redox processes on electrode surface, while rely charge transfer capacitive properties. electrical as indicators measuring impedance at different frequencies. By combining both approaches, it may possible obtain comprehensive understanding occurring patients. This lead more effective potentially opening up new avenues personalized treatment strategies. review explores current research approaches diagnosing using spectroscopy.

Язык: Английский

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Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4451 - 4451

Опубликована: Май 7, 2025

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD) pathogenesis, contributing to increased oxidative stress and impaired endo-lysosomal-proteasome system efficiency underlying neuronal injury. Genetic studies have identified 19 monogenic mutations—accounting for ~10% PD cases—that affect mitochondrial function are associated with early- or late-onset PD. Early-onset forms typically involve genes encoding proteins essential quality control, including mitophagy structural maintenance, while mutations impair dynamics, bioenergetics, trafficking. Atypical juvenile genetic syndromes also exhibit abnormalities. In idiopathic PD, environmental neurotoxins such as pesticides MPTP act inhibitors, disrupting complex I activity increasing reactive oxygen species. These converging pathways underscore mitochondria central node in pathology. This review explores the overlapping distinct mechanisms non-genetic emphasizing their role vulnerability. Targeting finally offers promising therapeutic avenue slow modify progression by intervening at key point neurodegenerative convergence.

Язык: Английский

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Comparative mapping of single‐cell transcriptomic landscapes in neurodegenerative diseases

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(5)

Опубликована: Май 1, 2025

Abstract INTRODUCTION Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's (PD) represent a spectrum of neurodegenerative diseases (NDDs). Here, we performed the first direct comparison their transcriptomic landscapes. METHODS We profiled whole transcriptomes NDD cortical tissue by single‐nucleus RNA sequencing, using computational analyses to identify common distinct differentially expressed genes (DEGs), pathways, vulnerable disease‐driver cell subtypes, altered cell‐to‐cell interactions. RESULTS The same inhibitory neuron subtype was depleted in both AD DLB. Potentially disease‐driving neuronal subtypes were identified PD Cell–cell communication predicted be increased but decreased DLB PD. DEGs most commonly shared across NDDs within subtypes. Overall, showed greatest divergence, while exhibited an intermediate signature. DISCUSSION These results may help explain clinicopathological these provide unique insights into molecular mechanisms underlying pathogenesis. Highlights population (AD) (DLB). discovered Differentially types. had showing

Язык: Английский

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Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseases

Опубликована: Дек. 18, 2024

ABSTRACT INTRODUCTION Alzheimer’s disease (AD), Dementia with Lewy bodies (DLB), and Parkinson’s (PD) represent a spectrum of neurodegenerative disorders (NDDs). Here, we performed the first direct comparison their transcriptomic landscapes. METHODS We profiled whole transcriptomes NDD cortical tissue by snRNA-seq. used computational analyses to identify common distinct differentially expressed genes (DEGs), biological pathways, vulnerable disease-driver cell subtypes, alteration in cell-to-cell interactions. RESULTS The same inhibitory neuron subtype was depleted both AD DLB. Potentially disease-driving neuronal subtypes were present PD Cell-cell communication predicted be increased but decreased DLB PD. DEGs most commonly shared across NDDs within subtypes. Overall, observed greatest divergence between PD, while exhibited an intermediate signature. DISCUSSION These results help explain clinicopathological this group provide unique insights into molecular mechanisms underlying pathogenesis NDDs.

Язык: Английский

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Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology

NeuroToxicology, Год журнала: 2024, Номер 103, С. 266 - 287

Опубликована: Июль 1, 2024

Язык: Английский

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