Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 734, С. 150778 - 150778
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of Biomedical Materials Research Part A, Год журнала: 2024, Номер 112(12), С. 2358 - 2371
Опубликована: Авг. 21, 2024
A severe disorder known as spinal cord damage causes both motor and sensory impairment in the limbs, significantly reducing patients' quality of life. After a injury, functional recovery therapy have emerged critical concerns. Hydrogel microspheres garnered lot interest lately because their enormous promise field injury rehabilitation. The material classification hydrogel (natural synthetic macromolecule polymers) synthesis methods are examined this work. This work also covers introduction several kinds use carriers realm treating injuries. Lastly, study reviews future prospects for highlights limitations problems. paper can offer feasible ideas researchers to advance application injury.
Язык: Английский
Процитировано
6
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 326 - 326
Опубликована: Фев. 26, 2024
Microneedles (MNs), renowned for their painless and minimally invasive qualities, exhibit significant potential facilitating effective drug delivery, vaccination, targeted sample extraction. Extracellular vesicles (EVs), serving as cargo MNs, are naturally occurring nanovesicles secreted by cells characterized novel biomarkers, low immunogenicity, cell-source-specific traits. MNs prove instrumental in extracting EVs from the fluid, thereby a promising diagnostic prognostic tool. To harness therapeutic of tissue repair, with sustained delivery leverage micron-sized channels to enhance site concentration, demonstrating efficacy treating various diseases, such Achillea tendinopathy, hair loss, spinal cord injury, diabetic ulcers. EV-loaded emerge platform repair applications skin, cardiac, tendon, hair, tissues. This review commences an overview subsequently delving into role MNs. The paper then synthesizes latest advancements use regenerative extending research progress disease diagnosis evaluations. It aims offer valuable insights forecast future trajectories hope inspiring innovative ideas among researchers this field.
Язык: Английский
Процитировано
4
Translational Neurodegeneration, Год журнала: 2024, Номер 13(1)
Опубликована: Дек. 6, 2024
Abstract Extracellular vesicles (EVs) are membrane originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced basic biological research to essential clinical significance. capacity selectively enrich specific subsets biofluids via distinctive surface markers opened new avenues for molecular understandings across various tissues and organs, notably In recent years, brain-derived have been extensively investigated as biomarkers, therapeutic targets, drug-delivery vehicles diseases. review provides a brief overview characteristics physiological functions classes EVs, focusing on mechanisms by which types mediate occurrence development Concurrently, novel approaches challenges use delivery delineated.
Язык: Английский
Процитировано
3
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 836 - 836
Опубликована: Янв. 20, 2025
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, molecular composition of EVs correlate to the cells origin, modulated cell’s environment pathologic state. proteins, DNA, RNA, protein cargo carried protected degradation, a role targeted intercellular signaling. These properties make salient targets as carriers biomarkers potential therapeutic delivery vehicles. majority EV research has focused on blood, urine, saliva, cerebrospinal fluid due easy accessibility. have also been identified studied ocular biofluids, including vitreous humor, aqueous tear film, study disease is new, promising, underexplored direction unique challenges considerations. This review covers recent advances diagnostic use EVs, focus human applications key preceding vitro vivo animal studies. We discuss future directions based other organ systems sates.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13
Опубликована: Апрель 23, 2025
Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.
Язык: Английский
Процитировано
0
Tissue Engineering Part B Reviews, Год журнала: 2025, Номер unknown
Опубликована: Май 5, 2025
Neurological disorders such as Alzheimer's disease, Parkinson's and stroke pose significant challenges for conventional therapy due to the complexities of blood-brain barrier (BBB) restricted delivery drugs central nervous system. Exosomes, a type small extracellular vesicle secreted by nearly all cell types, hold substantial promise vehicles therapeutic agents in treating these conditions. Notably, stem cell-secreted exosomes have emerged particularly effective their regenerative potential natural ability cross BBB. Similarly, hydrogels gained recognition versatile biomaterials capable supporting sustained release targeted therapeutics. The combination properties cell-derived (SC-Exos) with structural functional benefits offers promising approach enhancing neurogenesis, modulating neuroinflammation, facilitating tissue repair. This review explores origin, structure, modifications well synthesis incorporation methods context debilitating neurological disorders. It highlights recent advancements using SC-Exos delivery, addressing both current future applications. Improving our understanding loaded cargo transportation neural regeneration may pave way novel strategies.
Язык: Английский
Процитировано
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 139, С. 111393 - 111393
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Май 10, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2024, Номер 19(2), С. 2591 - 2614
Опубликована: Дек. 26, 2024
Neural stem cell (NSCs) transplantation is a promising therapeutic strategy for spinal cord injury (SCI), but its efficacy greatly limited by the local inhibitory microenvironment. In this study, based on l-arginine (l-Arg)-loaded mesoporous hollow cerium oxide (AhCeO2) nanospheres, we constructed an injectable composite hydrogel (AhCeO2-Gel) with microenvironment modulation capability. AhCeO2-Gel protected NSCs from oxidative damage eliminating excess reactive oxygen species while continuously delivering Nitric Oxide to lesion of SCI in pathological microenvironment, latter which effectively promoted neural differentiation NSCs. The process was confirmed be closely related up-regulation cAMP-PKA pathway after NO-induced calcium ion influx. addition, significantly polarization microglia toward M2 subtype as well enhanced regeneration nerves and myelinated axons. prepared bioactive system also efficiently facilitated integration transplanted host circuits, replenished damaged neurons, alleviated neuroinflammation, inhibited glial scar formation, thus accelerating recovery motor function rats. Therefore, synergized has great potential integrated treat comprehensively reversing
Язык: Английский
Процитировано
1
Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 734, С. 150778 - 150778
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0