Recent Advances in Drug Development for Hair Loss
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(8), С. 3461 - 3461
Опубликована: Апрель 8, 2025
Hair
loss
disorders
pose
a
substantial
global
health
burden,
affecting
millions
of
individuals
and
significantly
impacting
quality
life.
Despite
the
widespread
use
approved
therapeutics
like
minoxidil
finasteride,
their
clinical
efficacy
remains
limited.
These
challenges
underscore
pressing
need
for
more
targeted
effective
therapeutic
solutions.
This
review
examines
latest
innovations
in
hair
drug
discovery,
with
focus
on
small-molecule
inhibitors,
biologics,
stem
cell-based
therapies.
By
integrating
insights
from
molecular
mechanisms
leveraging
advancements
research
methods,
development
next-generation
holds
potential
to
transform
management
disorders.
Future
should
prioritize
antibody
therapy
treatments,
as
these
approaches
offer
unprecedented
opportunities
address
limitations
existing
options.
Antibody
therapies
enable
precise
targeting
key
pathways
involved
follicle
regulation,
providing
highly
specific
interventions.
Similarly,
therapies,
including
cell
transplantation
dermal
papilla
regeneration,
directly
regenerative
capacity
follicles,
offering
transformative
restoration.
Язык: Английский
Novel administration strategies for tissue-specific delivery of extracellular vesicles
Junyao Deng,
Qishan Li,
Fei Wang
и другие.
Extracellular Vesicle,
Год журнала:
2024,
Номер
4, С. 100057 - 100057
Опубликована: Ноя. 26, 2024
Язык: Английский
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12793 - 12815
Опубликована: Ноя. 1, 2024
Plant-derived
exosome-like
nanovesicles
(PELNs)
from
edible
plants,
isolated
by
ultracentrifugation,
size
exclusion
chromatography
or
other
methods,
were
proved
to
contain
a
variety
of
biologically
active
and
therapeutically
specific
components.
Recently,
investigations
in
the
field
PELN-based
biomedicine
have
been
conducted,
which
positioned
those
as
promising
tools
for
prevention
treatment
several
diseases,
with
their
natural
origin
potentially
offering
superior
biocompatibility
bioavailability.
However,
inadequate
targeting
limited
therapeutic
effects
constrain
utility
clinical
translation
PELNs.
Thus,
strategies
aiming
at
bridging
gap
engineering
PELNs
great
interest.
Those
approaches
include
membrane
hybridization,
physical
chemical
surface
functionalization
encapsulation
payloads.
Herein,
we
provide
comprehensive
overview
biogenesis
composition,
isolation
purification
methods
characterization
PELNs,
well
functions.
Current
knowledge
on
construction
biomedical
application
engineered
reviewed.
Additionally,
future
directions
perspectives
this
discussed
order
further
enrich
expand
prospects
Язык: Английский