Vagus nerve stimulation and gut microbiota interactions: a novel therapeutic avenue for neuropsychiatric disorders

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер unknown, С. 105990 - 105990

Опубликована: Дек. 1, 2024

The rising prevalence of treatment-resistant neuropsychiatric disorders underscores the need for innovative and effective treatment strategies. gut microbiota (GM) plays a pivotal role in progression these diseases, influencing brain mental health through gut-brain axis (GBA). vagus nerve significant GBA, making it key area focus potential novel therapeutic interventions. Vagus stimulation (VNS) was introduced approved as refractory forms some neuropsychological disorders, such depression epilepsy. Considering its impact on several regions that play vital part mood, motivation, affection, cognitive function, VNS has shown treating variety disorders. Harnessing to target bidirectional communication pathways linking GM VN could present an exciting approach Imbalances GM, dysbiosis, can impair between brain, contributing development shows modulating interconnected systems, helping restore balance. Interestingly, composition may also influence effectiveness VNS, modify brain's response this approach. This study provides comprehensive analysis relatively unexplored but noteworthy interaction In addition, we discussed mechanisms, potential, clinical implications GBA across

Язык: Английский

Can transcutaneous auricular vagus nerve stimulation be considered a viable adjuntive therapy in drug-resistant epilepsy? A systematic review and meta-analysis of randomized controlled trials

Epilepsy & Behavior, Год журнала: 2025, Номер 167, С. 110394 - 110394

Опубликована: Март 31, 2025

Язык: Английский