Microbial Pathogenesis, Год журнала: 2019, Номер 139, С. 103853 - 103853
Опубликована: Ноя. 13, 2019
Язык: Английский
Food Research International, Год журнала: 2023, Номер 167, С. 112730 - 112730
Опубликована: Март 21, 2023
Язык: Английский
Процитировано
47
npj Science of Food, Год журнала: 2023, Номер 7(1)
Опубликована: Июнь 5, 2023
Abstract The concept of probiotics is witnessing increasing attention due to its benefits in influencing the host microbiome and modulation immunity through strengthening gut barrier stimulation antibodies. These benefits, combined with need for improved nutraceuticals, have resulted extensive characterization leading an outburst data generated using several ‘omics’ technologies. recent development system biology approaches microbial science paving way integrating from different omics techniques understanding flow molecular information one level other clear on regulatory features phenotypes. limitations tendencies a ‘single omics’ application ignore influence processes justify ‘multi-omics’ selections action host. Different techniques, including genomics, transcriptomics, proteomics, metabolomics lipidomics, used studying their are discussed this review. Furthermore, rationale multi-omics integration platforms supporting analyses was also elucidated. This review showed that useful selecting functions microbiome. Hence, recommend approach holistically
Язык: Английский
Процитировано
44
Frontiers in Neuroanatomy, Год журнала: 2025, Номер 19
Опубликована: Фев. 12, 2025
The microbiota-gut-brain axis (MGBA) plays a significant role in the maintenance of brain structure and function. MGBA serves as conduit between CNS ENS, facilitating communication emotional cognitive centers via diverse pathways. In initial stages this review, we will examine way how affects neurogenesis, neuronal dendritic morphology, axonal myelination, microglia structure, blood barrier (BBB) permeability, synaptic structure. Furthermore, review potential mechanistic pathways neuroplasticity through influence. short-chain fatty acids (SCFAs) play pivotal MGBA, where they can modify BBB. We therefore discuss SCFAs influence microglia, neuronal, astrocyte function, well their disorders such Alzheimer’s disease (AD), Parkinson’s (PD). Subsequently, technical strategies employed to study interactions, including using germ-free (GF) animals, probiotics, fecal microbiota transplantation (FMT), antibiotics-induced dysbiosis. Finally, particular bacterial strains affect By gaining deeper understanding it may be possible facilitate research into microbial-based pharmacological interventions therapeutic for neurological diseases.
Язык: Английский
Процитировано
2
Foods, Год журнала: 2018, Номер 7(12), С. 195 - 195
Опубликована: Дек. 3, 2018
Changes in present-day society such as diets with more sugar, salt, and saturated fat, bad habits unhealthy lifestyles contribute to the likelihood of involvement microbiota inflammatory diseases, which global epidemics obesity, depression, mental health concerns. The is presently one hottest areas scientific medical research, exerts a marked influence on host during homeostasis disease. Fermented foods beverages are generally defined products made by microbial organisms enzymatic conversions major minor food components. Further commonly-recognized effects nutrition digestive (e.g., dysbiosis) well-being, there now strong evidence for impact fermented yoghurt, pickles, bread, kefir, beers, wines, mead), produced or preserved action microorganisms, general health, namely their significance gut balance brain functionality. require i.e., Saccharomyces yeasts lactic acid bacteria, yielding alcohol acid. Ingestion vibrant probiotics, especially those contained foods, found cause significant positive improvements balancing intestinal permeability barrier function. Our guts control deal every aspect our health. How we digest even sensitivities have linked mood, behavior, energy, weight, cravings, hormone balance, immunity, overall wellness. We highlight some impacts this domain debate calls convergence interdisciplinary research fields from United Nations’ initiative. Worldwide human animal medicine practiced separately; veterinary science neither considered nor inserted within national international Health discussions. absence clear definition subsequent vision future One may act transdisciplinary collaboration. point mini review role if need confluence feasible achievable, since they managed separate sectors limited communication.
Язык: Английский
Процитировано
142
Aging, Год журнала: 2020, Номер 12(6), С. 5539 - 5550
Опубликована: Март 19, 2020
Alzheimer's disease is characterized by the accumulation of amyloid and dysfunctional tau protein in brain along with final development dementia.Accumulation was observed 10-20 years before onset clinical symptoms diagnostic methods based on image analysis.This a serious public health problem, incidence prevalence being expected to reach epidemic proportions over next few decades if cannot be prevented or slowed down.Recently, addition strongly developing ischemic etiology disease, it suggested that gut microbiota may also participate this disease.The are thought form network called "gut-brain-microbiota axis", supported idea intestinal microflora can involved disease.Lately, many new studies have been conducted draw attention relationship between microbiota.This review presents possible microbiome.It promising for prevention therapeutic intervention.Modulation through personalized diet beneficial intervention like pro/prebiotics, changing microbiological partners their products, including protein, become treatment disease.www.aging-us.com5540 AGING escalation risk disease.Recent advances research suggest (oral, nasal, intestinal) dysbiosis during life lead systemic inflammatory response affect microglia immune brain.More more experimental data confirm key role interaction host neurodegeneration [5].What more, time, pathological permeability mucosa blood-brain barrier begins increase vicious circle formed irreversibly destroys neurons.It likely convergence from aging poor elderly contributes pathogenesis disease.Modifying composition food-based therapy pro/prebiotic supplementation create preventive options future depends progress disease.We must first understand how when bacteria promote disease.This aims highlight progression disease.
Язык: Английский
Процитировано
133
Brain Sciences, Год журнала: 2020, Номер 10(4), С. 206 - 206
Опубликована: Апрель 1, 2020
Parkinson's disease (PD) is one of the common long-term degenerative disorders that primarily affect motor systems. Gastrointestinal (GI) symptoms are in individuals with PD and often present before symptoms. It has been found gut dysbiosis to pathology related severity non-motor PD. Probiotics have reported ability improve constipation patients. However, evidence from preclinical or clinical research verify beneficial effects probiotics for functions still limited. An experimental animal model could be helpful exploring potential therapeutic strategy using probiotics. In current study, we examined whether daily administration neuroprotective on nigrostriatal dopamine neurons it can further alleviate dysfunctions mice. Transgenic MitoPark mice were chosen this study probiotic treatment gait, beam balance, coordination, degeneration levels dopaminergic identified. From results, compared sham group, significantly reduced impairments gait pattern, balance function, coordination. Immunohistochemically, a tyrosine hydroxylase (TH)-positive cell substantia nigra was preserved probiotic-treated These results showed attenuates deterioration Our data highlighted promising possibility use probiotics, which relevant approach application human subjects.
Язык: Английский
Процитировано
132
Journal of Clinical Medicine, Год журнала: 2018, Номер 7(12), С. 521 - 521
Опубликована: Дек. 7, 2018
The central nervous system (CNS) and the human gastrointestinal (GI) tract communicate through gut-brain axis (GBA). Such communication is bi-directional involves neuronal, endocrine, immunological mechanisms. There mounting data that gut microbiota source of a number neuroactive immunocompetent substances, which shape structure function brain regions involved in control emotions, cognition, physical activity. Most GI diseases are associated with altered transmission within GBA influenced by both genetic environmental factors. Current treatment protocols for non-GI disorders may positively or adversely affect composition intestinal diverse impact on therapeutic outcome(s). Alterations have been mood depressive disorders. Moreover, mental health frequently affected diseases. Deregulation constitute grip point development diagnostic tools personalized microbiota-based therapy. For example, next generation sequencing (NGS) offers detailed analysis microbiome footprints patients Elucidating role stem cell–host cross talks tissues might lead to diagnostics therapeutics. Psychobiotics new class beneficial bacteria documented efficacy Novel therapies interfering small molecules adult cell trafficking horizon.
Язык: Английский
Процитировано
117
iScience, Год журнала: 2020, Номер 23(8), С. 101414 - 101414
Опубликована: Июль 25, 2020
From ontogenesis to homeostasis, the phenotypes of complex organisms are shaped by bidirectional interactions between host and their associated microbiota. Current technology can reveal many such combining multi-omic data from both hosts microbes. However, exploring full extent these requires careful consideration study design for efficient generation optimal integration derived (meta)genomics, (meta)transcriptomics, (meta)proteomics, (meta)metabolomics. In this perspective, we introduce holo-omic approach that incorporates microbiota domains untangle interplay two. We revisit recent literature on biomolecular host-microbe discuss implementation current limitations approach. anticipate application contribute opening new research avenues discoveries in biomedicine, biotechnology, agricultural aquacultural sciences, nature conservation, as well basic ecological evolutionary research.
Язык: Английский
Процитировано
116
Neurobiology of Disease, Год журнала: 2019, Номер 132, С. 104580 - 104580
Опубликована: Авг. 24, 2019
Obesity is a global pandemic associated with macro- and microvascular endothelial dysfunction. Microvascular dysfunction has recently emerged as significant risk factor for the development of cognitive impairment. In this review, we present evidence from clinical preclinical studies supporting role obesity in Next, discuss how obesity-related hyperinsulinemia/insulin resistance, systemic inflammation, gut dysbiosis lead to impairment through induction disruption blood brain barrier. Finally, outline potential utility dietary interventions, exercise, bariatric surgery circumventing impacts on function.
Язык: Английский
Процитировано
102
Nutrients, Год журнала: 2021, Номер 13(1), С. 199 - 199
Опубликована: Янв. 10, 2021
Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications both mental health quality of life. Although the first 1000 days represent most critical period neurodevelopment, central peripheral nervous systems continue develop change throughout All this time, development functioning depend on many factors, including adequate nutrition. In review, we outline role nutrients cognitive, emotional, neural infants young children with special attention emerging roles polar lipids high (available) protein. Furthermore, discuss dynamic nature gut-brain axis importance microbial diversity relation a variety outcomes, maturation/function behavior are discussed. Finally, promising therapeutic potential psychobiotics modify gut ecology order improve well-being presented. Here, show that individual contribution nutrients, their interaction other micro- macronutrients way which they organized food matrix
Язык: Английский
Процитировано
101