Role of Fluid Dynamics in Infectious Disease Transmission: Insights from COVID-19 and Other Pathogens
Trends in Sciences,
Год журнала:
2024,
Номер
21(8), С. 8287 - 8287
Опубликована: Июнь 1, 2024
The
spread
of
infectious
diseases
such
as
COVID-19
depends
on
complex
fluid
dynamics
interactions
between
pathogens
and
phases,
including
individual
droplets
multiphase
clouds.
Understanding
these
is
crucial
for
predicting
controlling
disease
spread.
This
applies
to
human
animal
exhalations,
coughs
sneezes,
well
bursting
bubbles
that
create
micron-sized
in
various
indoor
outdoor
environments.
By
exploring
case
studies
this
regard,
study
examines
the
emerging
field
transmission,
focusing
flows,
interfacial
turbulence,
pathogens,
traffic,
aerosol
ventilation,
breathing
microenvironments.
These
results
indicate
increased
ventilation
rates
local
methods
can
effectively
reduce
concentration
SARS-CoV-2-laden
aerosols
immediate
spaces
individuals.
In
a
displacement-ventilated
room,
both
neutral
unstable
conditions
were
more
effective
removing
breathed
from
air,
regardless
presence
test
subjects.
However,
stable
may
increase
risk
infection
individuals
living
confined
spaces.
Thus,
findings
are
useful
providing
practical
guidance
managing
airborne
infections.
HIGHLIGHTS
Fluid
affect
transmission
explored
flow,
dispersion,
respiratory
zones
Increased
SARS-CoV-2
Displacement
eliminates
under
Cramped
damp
environments
GRAPHICAL
ABSTRACT
Язык: Английский
Amyotrophic lateral sclerosis; clinical features, differential diagnosis and pathology
International review of neurobiology,
Год журнала:
2024,
Номер
unknown, С. 1 - 47
Опубликована: Янв. 1, 2024
Язык: Английский
Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders
Neuroscience,
Год журнала:
2024,
Номер
565, С. 63 - 79
Опубликована: Ноя. 26, 2024
Язык: Английский
The neuroplastic brain: current breakthroughs and emerging frontiers
Brain Research,
Год журнала:
2025,
Номер
unknown, С. 149643 - 149643
Опубликована: Апрель 1, 2025
Язык: Английский
Mild cognitive impairment in amyotrophic lateral sclerosis: current view
Journal of Neural Transmission,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
Язык: Английский
The spectrum of behavioral disorders in amyotrophic lateral sclerosis: current view
Journal of Neural Transmission,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Язык: Английский
Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
Brain Research Bulletin,
Год журнала:
2024,
Номер
unknown, С. 111172 - 111172
Опубликована: Дек. 1, 2024
The
negative
interference
of
treatments
between
the
acetylcholinesterase
inhibitor
rivastigmine
and
tau
aggregation
hydromethylthionine
mesylate
(HMTM)
has
been
reported
in
Line
1
tau-transgenic
mice,
which
overexpress
a
truncated
species
protein
that
is
found
core
paired
helical
filaments
Alzheimer´s
disease
(AD).
However,
little
known
about
whether
such
interactions
could
affect
synapses
mice
overexpressing
carrying
pathogenic
mutations.
Here,
we
have
used
66
(L66)
full-length
human
P301S
mutation
as
model
accumulates
synapses.
We
measured
abundance
synaptic
proteins
(VAMP-2,
SNAP-25,
SNTX-1,
SYNPY-1,
SYN-1,
A-SYN)
immunohistochemically
to
reveal
structural
alterations
these
mice.
Tau
markers
were
also
examined
L66
treated
with
(15mg/kg)
(0.5mg/kg)
administered
singly
combination.
accumulated
mouse
brains,
levels
altered,
most
notably
decreased
SNAP-25
SYN-1.
A
decrease
accumulation
brains
caused
by
HMTM
was
partially
compromised
pretreatment.
Differences
induced
alone
not
identical
those
pretreated
rivastigmine.
prominent
differences
appeared
SNARE
complex
(SNAP-25,
VAMP-2,
SNTX-1),
but
interfered
HMTM-dependent
reduction
accumulation.
These
data
extend
our
previous
findings
L1
provide
evidence
for
mechanism
symptomatic
disease-modifying
dementia
therapies
an
explanation
similar
drug
observed
clinical
trials.
Язык: Английский