Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia DOI Creative Commons
Karima Schwab,

Lianne Robinson,

Anne Annschuetz

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: unknown, P. 111172 - 111172

Published: Dec. 1, 2024

The negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and tau aggregation hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated species protein that is found core paired helical filaments Alzheimer´s disease (AD). However, little known about whether such interactions could affect synapses mice overexpressing carrying pathogenic mutations. Here, we have used 66 (L66) full-length human P301S mutation as model accumulates synapses. We measured abundance synaptic proteins (VAMP-2, SNAP-25, SNTX-1, SYNPY-1, SYN-1, A-SYN) immunohistochemically to reveal structural alterations these mice. Tau markers were also examined L66 treated with (15mg/kg) (0.5mg/kg) administered singly combination. accumulated mouse brains, levels altered, most notably decreased SNAP-25 SYN-1. A decrease accumulation brains caused by HMTM was partially compromised pretreatment. Differences induced alone not identical those pretreated rivastigmine. prominent differences appeared SNARE complex (SNAP-25, VAMP-2, SNTX-1), but interfered HMTM-dependent reduction accumulation. These data extend our previous findings L1 provide evidence for mechanism symptomatic disease-modifying dementia therapies an explanation similar drug observed clinical trials.

Language: Английский

Role of Fluid Dynamics in Infectious Disease Transmission: Insights from COVID-19 and Other Pathogens DOI Creative Commons
Soumyajit Koley

Trends in Sciences, Journal Year: 2024, Volume and Issue: 21(8), P. 8287 - 8287

Published: June 1, 2024

The spread of infectious diseases such as COVID-19 depends on complex fluid dynamics interactions between pathogens and phases, including individual droplets multiphase clouds. Understanding these is crucial for predicting controlling disease spread. This applies to human animal exhalations, coughs sneezes, well bursting bubbles that create micron-sized in various indoor outdoor environments. By exploring case studies this regard, study examines the emerging field transmission, focusing flows, interfacial turbulence, pathogens, traffic, aerosol ventilation, breathing microenvironments. These results indicate increased ventilation rates local methods can effectively reduce concentration SARS-CoV-2-laden aerosols immediate spaces individuals. In a displacement-ventilated room, both neutral unstable conditions were more effective removing breathed from air, regardless presence test subjects. However, stable may increase risk infection individuals living confined spaces. Thus, findings are useful providing practical guidance managing airborne infections. HIGHLIGHTS Fluid affect transmission explored flow, dispersion, respiratory zones Increased SARS-CoV-2 Displacement eliminates under Cramped damp environments GRAPHICAL ABSTRACT

Language: Английский

Citations

21
Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders DOI
Mayur B. Kale, Nitu L. Wankhede, Ashok Kumar Bishoyi

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 565, P. 63 - 79

Published: Nov. 26, 2024

Language: Английский

Citations

5
Amyotrophic lateral sclerosis; clinical features, differential diagnosis and pathology DOI
Michael A. van Es

International review of neurobiology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 47

Published: Jan. 1, 2024

Language: Английский

Citations

4
The neuroplastic brain: current breakthroughs and emerging frontiers DOI Creative Commons
Parisa Gazerani

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149643 - 149643

Published: April 1, 2025

Language: Английский

Citations

0
The spectrum of behavioral disorders in amyotrophic lateral sclerosis: current view DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Language: Английский

Citations

0
Mild cognitive impairment in amyotrophic lateral sclerosis: current view DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Language: Английский

Citations

0
Rivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia DOI Creative Commons
Karima Schwab,

Lianne Robinson,

Anne Annschuetz

et al.

Brain Research Bulletin, Journal Year: 2024, Volume and Issue: unknown, P. 111172 - 111172

Published: Dec. 1, 2024

The negative interference of treatments between the acetylcholinesterase inhibitor rivastigmine and tau aggregation hydromethylthionine mesylate (HMTM) has been reported in Line 1 tau-transgenic mice, which overexpress a truncated species protein that is found core paired helical filaments Alzheimer´s disease (AD). However, little known about whether such interactions could affect synapses mice overexpressing carrying pathogenic mutations. Here, we have used 66 (L66) full-length human P301S mutation as model accumulates synapses. We measured abundance synaptic proteins (VAMP-2, SNAP-25, SNTX-1, SYNPY-1, SYN-1, A-SYN) immunohistochemically to reveal structural alterations these mice. Tau markers were also examined L66 treated with (15mg/kg) (0.5mg/kg) administered singly combination. accumulated mouse brains, levels altered, most notably decreased SNAP-25 SYN-1. A decrease accumulation brains caused by HMTM was partially compromised pretreatment. Differences induced alone not identical those pretreated rivastigmine. prominent differences appeared SNARE complex (SNAP-25, VAMP-2, SNTX-1), but interfered HMTM-dependent reduction accumulation. These data extend our previous findings L1 provide evidence for mechanism symptomatic disease-modifying dementia therapies an explanation similar drug observed clinical trials.

Language: Английский

Citations

0