Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review DOI Creative Commons
Matteo Costanzo,

Carolina Cutrona,

Giorgio Leodori

и другие.

Alzheimer s Research & Therapy, Год журнала: 2024, Номер 16(1)

Опубликована: Ноя. 4, 2024

Alzheimer disease (AD) remains a significant global health concern. The progression from preclinical stages to overt dementia has become crucial point of interest for researchers. This paper reviews the potential neurophysiological biomarkers in predicting AD progression, based on systematic literature search following PRISMA guidelines, including 55 studies. EEG-based techniques have been predominantly employed, whereas TMS studies are less common. Among investigated measures, spectral power measurements and event-related potentials-based P300 N200 latencies, emerged as most consistent reliable likelihood conversion AD. In addition, TMS-based indices cortical excitability synaptic plasticity also shown assessing risk However, concerns persist regarding methodological discrepancies among studies, accuracy these measures comparison established biomarkers, their immediate clinical applicability. Further research is needed validate predictive capabilities EEG measures. Advancements this area could lead cost-effective, enhancing diagnostic processes deepening our understanding pathophysiology.

Язык: Английский

Alzheimer’s disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity DOI Creative Commons

Matea Pavešković,

Ruth B. De-Paula,

Shamsideen A. Ojelade

и другие.

Human Molecular Genetics, Год журнала: 2024, Номер 33(20), С. 1815 - 1832

Опубликована: Авг. 15, 2024

Abstract CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer’s disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP broadly expressed adult mouse brain, including within cortical and hippocampal neurons, where it detected at pre-synaptic terminals. Deletion of Cd2ap altered dendritic branching spine density, impaired ubiquitin-proteasome activity. Moreover, mice harboring either one or two copies germline null allele, we noted increased paired-pulse facilitation Schaffer-collateral synapses, consistent with haploinsufficient requirement release. Whereas conditional knockout brain revealed no gross behavioral deficits 3.5- 12-month-old mice, heterozygous demonstrated subtle impairments discrimination learning using touchscreen task. Based on unbiased proteomics, partial complete loss triggered perturbation proteins roles folding, lipid metabolism, proteostasis, synaptic function. Overall, our results reveal conserved, dose-sensitive requirements maintenance neuronal structure function, homeostasis plasticity, inform understanding possible cell-type specific mechanisms Disease.

Язык: Английский

Процитировано

5
Radiotherapy for non-cancer diseases: benefits and long-term risks DOI
Juliette Thariat, Mark P. Little, Lydia B. Zablotska

и другие.

International Journal of Radiation Biology, Год журнала: 2024, Номер 100(4), С. 505 - 526

Опубликована: Янв. 5, 2024

Purpose The discovery of X-rays was followed by a variety attempts to treat infectious diseases and various other non-cancer with ionizing radiation, in addition cancer. There has been recent resurgence interest the use such radiotherapy for diseases. Non-cancer which currently proposed include refractory ventricular tachycardia, neurodegenerative (e.g. Alzheimer's disease dementia), Coronavirus Disease 2019 (COVID-19) pneumonia, all ongoing clinical studies that deliver radiation doses 0.5–25 Gy single fraction or multiple daily fractions. In effects, historical indications predominantly used some countries Germany) osteoarthritis degenerative bones joints. This narrative review gives an overview biological rationale preclinical diseases, discusses plausibility rationale, considers long-term risks cancer

Язык: Английский

Процитировано

4
Effects of accelerated intermittent theta-burst stimulation in modulating brain of Alzheimer’s disease DOI
Hua Lin, Junhua Liang, Qianqian Wang

и другие.

Cerebral Cortex, Год журнала: 2024, Номер 34(3)

Опубликована: Март 1, 2024

Abstract Intermittent theta-burst stimulation (iTBS) is emerging as a noninvasive therapeutic strategy for Alzheimer's disease (AD). Recent advances highlighted new accelerated iTBS (aiTBS) protocol, consisting of multiple sessions per day and higher overall pulse doses, in brain modulation. To examine the possibility applying aiTBS treating AD patients, we enrolled 45 patients at early clinical stages, they were randomly assigned to either receive real or sham aiTBS. Neuropsychological scores evaluated before after treatment. Moreover, detected cortical excitability oscillatory activity changes AD, by single-pulse TMS combination with EEG (TMS-EEG). Real showed markedly better performances group average Auditory Verbal Learning Test compared baseline. TMS-EEG revealed that has reinforced this memory-related mechanism increasing beta underlying target. We also found an enhancement local natural frequency The novel findings implicated high-dose targeting left DLPFC rapid-acting, safe, tolerable patients. Furthermore, TMS-related increase specific neural oscillation elucidates mechanisms cognitive impairment ameliorated

Язык: Английский

Процитировано

4
Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma DOI Creative Commons
Sana El Hajji, Yukihiro Shiga, Nicolás Belforte

и другие.

Science Advances, Год журнала: 2024, Номер 10(32)

Опубликована: Авг. 7, 2024

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature of neurodegenerative diseases. There is lack strategies that target dendritic regeneration to promote neurorecovery. We show daily human recombinant insulin eye drops stimulate retinal ganglion cell (RGC) dendrite synapse during ocular hypertension, risk factor develop glaucoma. demonstrate the ribosomal protein p70S6 kinase (S6K) essential for insulin-dependent regrowth. Furthermore, S6K phosphorylation stress-activated kinase-interacting 1 (SIN1), link between mammalian rapamycin complexes 2 (mTORC1/2), required insulin-induced regeneration. Using two-photon microscopy live imaging, we rescues single-RGC light-evoked calcium (Ca

Язык: Английский

Процитировано

4
Calcineurin inhibition prevents synaptic plasticity deficit induced by brain-derived tau oligomers DOI Creative Commons
Pietro Scaduto, Michela Marcatti, Nemil Bhatt

и другие.

Brain Communications, Год журнала: 2024, Номер 6(5)

Опубликована: Янв. 1, 2024

Abstract Compelling evidence suggests that cognitive decline in Alzheimer’s disease is associated with the accumulation and aggregation of tau protein, most toxic aggregates being form oligomers. This underscores necessity for direct isolation analysis brain-derived oligomers from patients disease, potentially offering novel perspectives into toxicity. are potent inhibitors synaptic plasticity; however, involved mechanism still not fully understood. We previously reported a significantly reduced incidence ageing humans chronically treated Food Drug Administration–approved calcineurin inhibitor, FK506 (tacrolimus), used as an immunosuppressant after solid organ transplant. Using combination electrophysiological RNA-sequencing techniques, we provide here has potential to block acute effect on plasticity, well restore levels some key mRNAs. These results further support promising therapeutic strategy treatment disease.

Язык: Английский

Процитировано

4
Cognitive Frailty: A Comprehensive Clinical Paradigm Beyond Cognitive Decline DOI
Mariagiovanna Cozza, Virginia Boccardi

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102738 - 102738

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Unlocking the cellular mystery: how proton pump inhibitors may alter the dementia landscape DOI
Maneesh Mohan, Ashi Mannan,

Shareen Singh

и другие.

Brain Research, Год журнала: 2025, Номер unknown, С. 149702 - 149702

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Chronic Imaging of Dendritic Spine Morphology in Transgenic Mice of the 5xFAD-M Hybrid Strain, a Model of Alzheimer’s Disease DOI
А. Е. Матухно,

P. V. Tkacheva,

V. B. Voinov

и другие.

Neuroscience and Behavioral Physiology, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Язык: Английский

Процитировано

0
Mitochondria transfer as a potential therapeutic mechanism in Alzheimer’s disease-like pathology DOI

Mohil Mishra,

Shalini Raik, Vidya Rattan

и другие.

Brain Research, Год журнала: 2023, Номер 1819, С. 148544 - 148544

Опубликована: Авг. 22, 2023

Язык: Английский

Процитировано

9
Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease DOI Open Access

Éva Kiss,

Stefan Kins,

Karin Gorgas

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4165 - 4165

Опубликована: Апрель 9, 2024

Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer’s disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different animal models through the regulation wide range cellular processes, energy homeostasis, apoptosis, proliferation inflammatory pathways. In this review, we aimed provide an up-to-date overview experimental evidence documenting neuroprotective activities artemi-sinins underscore potential these already-approved drugs treating also humans propose their consideration carefully designed clinical trials. particular, benefits main pathological hallmarks events cascade throughout development are summarized. Moreover, dose- context-dependent effects artemisinins noted.

Язык: Английский

Процитировано

3