Journal of Neurochemistry,
Год журнала:
2025,
Номер
169(2)
Опубликована: Фев. 1, 2025
Synapse
elimination
is
an
essential
process
in
the
healthy
nervous
system
and
dysregulated
many
neuropathologies.
Yet,
underlying
molecular
mechanisms
under
what
conditions
they
occur
remain
unclear.
MFG-E8
a
secreted
glycoprotein
well
known
to
act
as
opsonin,
tagging
stressed
dying
cells
for
engulfment
by
phagocytes.
Opsonization
of
debris
microglial
phagocytosis
CNS
established,
its
role
astrocytic
phagocytosis,
trogocytosis-like
synapses
beginning
be
explored.
However,
MFG-E8's
function
other
tissues
highly
diverse,
evidence
suggests
that
on
synapse
particular
may
more
complex
varied
than
opsonization.
In
this
review,
we
outline
documented
direct
indirect
effects
elimination,
while
also
proposing
potential
roles
explored
further,
particular,
cytoskeletal
reorganization
neurites
glia
leading
various
mechanisms.
Finally,
demonstrate
need
several
open
questions
answered-chiefly,
might
MFG-E8-mediated
favor
mechanisms,
when
activity
dysregulated,
increasing
unwanted
neurotoxicity?
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 788 - 788
Опубликована: Июнь 16, 2024
The
COVID-19
pandemic,
caused
by
infection
with
the
SARS-CoV-2
virus,
is
associated
cognitive
impairment
and
Alzheimer’s
disease
(AD)
progression.
Once
it
enters
brain,
virus
stimulates
accumulation
of
amyloids
in
brain
that
are
highly
toxic
to
neural
cells.
These
may
trigger
neurological
symptoms
COVID-19.
meningeal
lymphatic
vessels
(MLVs)
play
an
important
role
removal
toxins
mediate
viral
drainage
from
brain.
MLVs
considered
a
promising
target
prevent
COVID-19-exacerbated
dementia.
However,
there
limited
methods
for
augmentation
MLV
function.
This
review
highlights
new
discoveries
field
COVID-19-mediated
amyloid
development
strategies
stimulate
clearance
through
other
pathways.
based
on
innovative
treating
dysfunction
induced
infection,
including
use
photobiomodulation,
plasmalogens,
medicinal
herbs,
which
offer
hope
addressing
challenges
posed
virus.
International Journal of Radiation Biology,
Год журнала:
2024,
Номер
100(4), С. 505 - 526
Опубликована: Янв. 5, 2024
Purpose
The
discovery
of
X-rays
was
followed
by
a
variety
attempts
to
treat
infectious
diseases
and
various
other
non-cancer
with
ionizing
radiation,
in
addition
cancer.
There
has
been
recent
resurgence
interest
the
use
such
radiotherapy
for
diseases.
Non-cancer
which
currently
proposed
include
refractory
ventricular
tachycardia,
neurodegenerative
(e.g.
Alzheimer's
disease
dementia),
Coronavirus
Disease
2019
(COVID-19)
pneumonia,
all
ongoing
clinical
studies
that
deliver
radiation
doses
0.5–25
Gy
single
fraction
or
multiple
daily
fractions.
In
effects,
historical
indications
predominantly
used
some
countries
Germany)
osteoarthritis
degenerative
bones
joints.
This
narrative
review
gives
an
overview
biological
rationale
preclinical
diseases,
discusses
plausibility
rationale,
considers
long-term
risks
cancer
Dendrite
pathology
and
synaptic
loss
result
in
neural
circuit
dysfunction,
a
common
feature
of
neurodegenerative
diseases.
There
is
lack
strategies
that
target
dendritic
regeneration
to
promote
neurorecovery.
We
show
daily
human
recombinant
insulin
eye
drops
stimulate
retinal
ganglion
cell
(RGC)
dendrite
synapse
during
ocular
hypertension,
risk
factor
develop
glaucoma.
demonstrate
the
ribosomal
protein
p70S6
kinase
(S6K)
essential
for
insulin-dependent
regrowth.
Furthermore,
S6K
phosphorylation
stress-activated
kinase-interacting
1
(SIN1),
link
between
mammalian
rapamycin
complexes
2
(mTORC1/2),
required
insulin-induced
regeneration.
Using
two-photon
microscopy
live
imaging,
we
rescues
single-RGC
light-evoked
calcium
(Ca
Brain Communications,
Год журнала:
2024,
Номер
6(5)
Опубликована: Янв. 1, 2024
Abstract
Compelling
evidence
suggests
that
cognitive
decline
in
Alzheimer’s
disease
is
associated
with
the
accumulation
and
aggregation
of
tau
protein,
most
toxic
aggregates
being
form
oligomers.
This
underscores
necessity
for
direct
isolation
analysis
brain-derived
oligomers
from
patients
disease,
potentially
offering
novel
perspectives
into
toxicity.
are
potent
inhibitors
synaptic
plasticity;
however,
involved
mechanism
still
not
fully
understood.
We
previously
reported
a
significantly
reduced
incidence
ageing
humans
chronically
treated
Food
Drug
Administration–approved
calcineurin
inhibitor,
FK506
(tacrolimus),
used
as
an
immunosuppressant
after
solid
organ
transplant.
Using
combination
electrophysiological
RNA-sequencing
techniques,
we
provide
here
has
potential
to
block
acute
effect
on
plasticity,
well
restore
levels
some
key
mRNAs.
These
results
further
support
promising
therapeutic
strategy
treatment
disease.
Alzheimer s Research & Therapy,
Год журнала:
2024,
Номер
16(1)
Опубликована: Ноя. 4, 2024
Alzheimer
disease
(AD)
remains
a
significant
global
health
concern.
The
progression
from
preclinical
stages
to
overt
dementia
has
become
crucial
point
of
interest
for
researchers.
This
paper
reviews
the
potential
neurophysiological
biomarkers
in
predicting
AD
progression,
based
on
systematic
literature
search
following
PRISMA
guidelines,
including
55
studies.
EEG-based
techniques
have
been
predominantly
employed,
whereas
TMS
studies
are
less
common.
Among
investigated
measures,
spectral
power
measurements
and
event-related
potentials-based
P300
N200
latencies,
emerged
as
most
consistent
reliable
likelihood
conversion
AD.
In
addition,
TMS-based
indices
cortical
excitability
synaptic
plasticity
also
shown
assessing
risk
However,
concerns
persist
regarding
methodological
discrepancies
among
studies,
accuracy
these
measures
comparison
established
biomarkers,
their
immediate
clinical
applicability.
Further
research
is
needed
validate
predictive
capabilities
EEG
measures.
Advancements
this
area
could
lead
cost-effective,
enhancing
diagnostic
processes
deepening
our
understanding
pathophysiology.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4165 - 4165
Опубликована: Апрель 9, 2024
Plant-derived
multitarget
compounds
may
represent
a
promising
therapeutic
strategy
for
multifactorial
diseases,
such
as
Alzheimer’s
disease
(AD).
Artemisinin
and
its
derivatives
were
indicated
to
beneficially
modulate
various
aspects
of
AD
pathology
in
different
animal
models
through
the
regulation
wide
range
cellular
processes,
energy
homeostasis,
apoptosis,
proliferation
inflammatory
pathways.
In
this
review,
we
aimed
provide
an
up-to-date
overview
experimental
evidence
documenting
neuroprotective
activities
artemi-sinins
underscore
potential
these
already-approved
drugs
treating
also
humans
propose
their
consideration
carefully
designed
clinical
trials.
particular,
benefits
main
pathological
hallmarks
events
cascade
throughout
development
are
summarized.
Moreover,
dose-
context-dependent
effects
artemisinins
noted.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Май 10, 2024
Research
has
shown
disrupted
structural
network
measures
related
to
cognitive
decline
and
future
cortical
atrophy
during
the
progression
of
Alzheimer's
disease
(AD).
However,
evidence
regarding
individual
variability
gray
matter
associations
with
concurrent
AD
is
still
sparse.
Neuropharmacology,
Год журнала:
2024,
Номер
255, С. 110006 - 110006
Опубликована: Май 18, 2024
Currently,
there
are
no
effective
therapeutic
agents
available
to
treat
Alzheimer's
disease
(AD).
However,
edaravone
dexborneol
(EDB),
a
novel
composite
agent
used
acute
ischemic
stroke,
has
recently
been
shown
exert
efficacious
neuroprotective
effects.
whether
EDB
can
ameliorate
cognitive
deficits
in
AD
currently
remains
unclear.
To
this
end,
we
explored
the
effects
of
on
and
its
potential
mechanisms
using
an
animal
model
(male
APP/PS1
mice)
treated
with
for
10
weeks
starting
at
6
months
age.
Subsequent
analyses
revealed
that
EDB-treated
mice
exhibited
improved
abilities
compared
untreated
mice.
Administration
further
alleviated
neuropathological
alterations
hippocampus,
including
Aβ
deposition,
pyramidal
cell
karyopyknosis,
oxidative
damage,
significantly
decreased
levels
inflammatory
cytokines
(IL-1β,
IL-6
TNF-α)
COX-2
hippocampus
Transcriptome
sequencing
analysis
demonstrated
critical
role
reaction
treatment
mice,
indicating
alleviation
by
was
linked
action
TREM2/TLR4/MAPK
signaling
pathway.
Further
vitro
investigations
showed
suppressed
neuroinflammation
LPS-stimulated
BV2
cells
inhibiting
TLR4/MAPK
pathway
upregulating
TREM2
expression.
Thus,
findings
present
study
demonstrate
is
promising
AD-related
dysfunction.