Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning DOI Creative Commons
Alice Geminiani, Claudia Casellato,

H-J Boele

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 23, 2023

Abstract According to Marr’s motor learning theory, plasticity at the parallel fibre Purkinje cells synapse ( pf -PC) is main substrate responsible for sensorimotor contingencies under climbing control. However, discovery of multiple forms distributed over different cerebellar circuit synapses prompts remap sites. Here, we have simulated classical eyeblink conditioning (CEBC) using an advanced spiking model embedding upbound and downbound modules that are subject rules. Simulations show synaptic regulates cascade precise patterns spreading throughout cortex nuclei. CEBC was supported by in both -PC feedforward inhibitory loop passing through molecular layer interneurons (MLIs), but only combined switch-off sites compromised significantly. By differentially engaging information related plasticity, contributed generate a well-timed conditioned response, it module played major role this process. The outcomes our simulations closely align with behavioural electrophysiological phenotypes mutant mice suffering from cell-specific mutations affect processing their PC or MLI synapses. Our data highlight synergy bidirectional rules across cerebellum facilitate finetuning adaptive associative behaviours high spatiotemporal resolution.

Язык: Английский

Addressing inconsistency in functional neuroimaging: A replicable data-driven multi-scale functional atlas for canonical brain networks DOI Creative Commons
Kyle M. Jensen, Jessica A. Turner, Vince D. Calhoun

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

The advent of various neuroimaging methodologies has greatly aided in the conceptualization large-scale brain networks field cognitive neuroscience. However, there is inconsistency across studies both nomenclature and functional entities being described. There a need for unifying framework which standardizes terminology while also bringing analyses results into same reference space. Here we present whole-brain atlas canonical derived from more than 100k resting-state fMRI datasets. These data-driven are highly replicable datasets as well multiple spatial scales. We have organized, labeled, described them with terms familiar to fields affective neuroscience order optimize their utility future enhance accessibility new findings. benefits this not limited template-based or reference-guided analyses, but extend other approaches modalities, such those using blind independent component analysis (ICA). Future utilizing will contribute greater harmonization standardization research.

Язык: Английский

Процитировано

3
Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism DOI Creative Commons

Sabina Couto-Ovejero,

Jingjing Ye, Peter C. Kind

и другие.

Frontiers in Systems Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Ноя. 21, 2023

Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend non-motor realms, such as fear-based emotional processing and these are supported by interactions with wide range brain structures. Research related the contributions has focussed primarily on use well-constrained conditioning paradigms in both human non-human subjects. From studies, circuits appear be critically involved conditioned unconditioned responses threatening stimuli addition encoding storage fear memory. It hypothesised computational mechanism underlying this contribution may involve internal models, where errors between actual expected outcomes computed within circuitry cerebellum. clinical perspective, abnormalities consistently neurodevelopmental disorders, including autism. Importantly, atypical adaptive behaviour heightened anxiety also common amongst autistic individuals. In review, we provide an overview current anatomical, physiological theoretical understanding foster further insights into neural dysregulation observed people

Язык: Английский

Процитировано

4
The cerebellar nuclei take center stage DOI
Dana Cohen

Current Opinion in Behavioral Sciences, Год журнала: 2024, Номер 57, С. 101362 - 101362

Опубликована: Март 23, 2024

Язык: Английский

Процитировано

1
Cerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action DOI Creative Commons
Roberta Lorenzi,

Gökçe Korkmaz,

Adnan Alahmadi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Abstract The motor learning theory anticipates that cerebro-cerebellar loops perform sensorimotor prediction thereby regulating control. This operation has been identified during action execution (AE) and observation (AO) but the causal interaction between cerebellum cerebral cortex remained unclear. Here we used Dynamic Causal Modelling (DCM) to study functional MRI (fMRI) data obtained a squeeze ball task in either AE or AO conditions. In both cases, active regions included bilateral primary visual (V1), left (M1), supplementary premotor (SMAPMC), cingulate (CC), superior parietal lobule (SPL), right (CRBL). networks showed same fixed effective connectivity, with pathways V1, CRBL, SMAPMC CC wired closed loop. However, cerebellar communication towards switched from excitatory inhibitory AO. Moreover, only, signal modulation was non-linear CRBL within self-connection, supporting role of elaborating plans received SMAPMC. Thus, need for planning presence feedback discriminate modality forward control operated by on While underlying circuit mechanisms remain be determined, these results reveal differentially controls excitatory/inhibitory dynamics inter-regional connectivity depending its engagement, opening new prospective design artificial controllers investigation neurological diseases.

Язык: Английский

Процитировано

0
Maternal Immune Activation and Peripubertal Stress Synergistically Disrupt Cerebellar Plasticity Integration and Impair Motor Coordination Learning DOI
Momoka Hikosaka, Nobutake Hosoi,

Myung-Si Yang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Exploring the Effects of ITBS Intervention on Rat Cerebellar Neural Oscillations and its Neural Mechanisms DOI
Tianling Wang, Xue Yang, Shuxian Zhang

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells DOI Creative Commons
Francesca Prestori,

Eleonora Pali,

Stefano Masoli

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Abstract Cerebellar Golgi cells (GoCs) segregate parallel fiber (pf) and mossy (mf) inputs on apical basal dendrites. Computational modelling predicted that this anatomical arrangement, coupled with a specific ionic channel localization, could be instrumental to drive spike-timing dependent plasticity (STDP) at mf-GoC synapses. Here, we have tested hypothesis GoC patch-clamp recordings in acute mouse cerebellar slices. Indeed, repeated mf-pf pairing the theta-band (1 Hz

Язык: Английский

Процитировано

0
Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex DOI Creative Commons
Simon Bossi,

Hervé Daniel,

Heather Mclean

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 15, 2024

The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by variety of presynaptic receptors, notably type 4 metabotropic glutamate (mGlu4) receptors 1 adenosine (A1) both which curtail release upon activation. Despite their regulating synaptic transmission within the cortex, functional interactions mGlu4 A1 have remained relatively unexplored. To bridge this gap, our study delves into how receptor activity influences receptor-mediated alterations excitatory transmission. Employing combination whole-cell patch clamp recordings fiber fluorometric calcium measurements acute rat mouse cortical slices, results reveal these types. These findings hold implications for understanding potential roles neuroprotection during pathophysiological conditions characterized elevated levels.

Язык: Английский

Процитировано

0
Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning DOI Creative Commons
Alice Geminiani, Claudia Casellato,

H-J Boele

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июнь 23, 2023

Abstract According to Marr’s motor learning theory, plasticity at the parallel fibre Purkinje cells synapse ( pf -PC) is main substrate responsible for sensorimotor contingencies under climbing control. However, discovery of multiple forms distributed over different cerebellar circuit synapses prompts remap sites. Here, we have simulated classical eyeblink conditioning (CEBC) using an advanced spiking model embedding upbound and downbound modules that are subject rules. Simulations show synaptic regulates cascade precise patterns spreading throughout cortex nuclei. CEBC was supported by in both -PC feedforward inhibitory loop passing through molecular layer interneurons (MLIs), but only combined switch-off sites compromised significantly. By differentially engaging information related plasticity, contributed generate a well-timed conditioned response, it module played major role this process. The outcomes our simulations closely align with behavioural electrophysiological phenotypes mutant mice suffering from cell-specific mutations affect processing their PC or MLI synapses. Our data highlight synergy bidirectional rules across cerebellum facilitate finetuning adaptive associative behaviours high spatiotemporal resolution.

Язык: Английский

Процитировано

0