Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning DOI Creative Commons
Alice Geminiani, Claudia Casellato,

H-J Boele

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 23, 2023

Abstract According to Marr’s motor learning theory, plasticity at the parallel fibre Purkinje cells synapse ( pf -PC) is main substrate responsible for sensorimotor contingencies under climbing control. However, discovery of multiple forms distributed over different cerebellar circuit synapses prompts remap sites. Here, we have simulated classical eyeblink conditioning (CEBC) using an advanced spiking model embedding upbound and downbound modules that are subject rules. Simulations show synaptic regulates cascade precise patterns spreading throughout cortex nuclei. CEBC was supported by in both -PC feedforward inhibitory loop passing through molecular layer interneurons (MLIs), but only combined switch-off sites compromised significantly. By differentially engaging information related plasticity, contributed generate a well-timed conditioned response, it module played major role this process. The outcomes our simulations closely align with behavioural electrophysiological phenotypes mutant mice suffering from cell-specific mutations affect processing their PC or MLI synapses. Our data highlight synergy bidirectional rules across cerebellum facilitate finetuning adaptive associative behaviours high spatiotemporal resolution.

Language: Английский

The cerebellar nuclei take center stage DOI
Dana Cohen

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 57, P. 101362 - 101362

Published: March 23, 2024

Language: Английский

Citations

1
Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism DOI Creative Commons

Sabina Couto-Ovejero,

Jingjing Ye, Peter C. Kind

et al.

Frontiers in Systems Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Nov. 21, 2023

Cerebellar networks have traditionally been linked to sensorimotor control. However, a large body of evidence suggests that cerebellar functions extend non-motor realms, such as fear-based emotional processing and these are supported by interactions with wide range brain structures. Research related the contributions has focussed primarily on use well-constrained conditioning paradigms in both human non-human subjects. From studies, circuits appear be critically involved conditioned unconditioned responses threatening stimuli addition encoding storage fear memory. It hypothesised computational mechanism underlying this contribution may involve internal models, where errors between actual expected outcomes computed within circuitry cerebellum. clinical perspective, abnormalities consistently neurodevelopmental disorders, including autism. Importantly, atypical adaptive behaviour heightened anxiety also common amongst autistic individuals. In review, we provide an overview current anatomical, physiological theoretical understanding foster further insights into neural dysregulation observed people

Language: Английский

Citations

2
Cerebellar control over inter-regional excitatory/inhibitory dynamics discriminates execution from observation of an action DOI Creative Commons
Roberta Lorenzi,

Gökçe Korkmaz,

Adnan Alahmadi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract The motor learning theory anticipates that cerebro-cerebellar loops perform sensorimotor prediction thereby regulating control. This operation has been identified during action execution (AE) and observation (AO) but the causal interaction between cerebellum cerebral cortex remained unclear. Here we used Dynamic Causal Modelling (DCM) to study functional MRI (fMRI) data obtained a squeeze ball task in either AE or AO conditions. In both cases, active regions included bilateral primary visual (V1), left (M1), supplementary premotor (SMAPMC), cingulate (CC), superior parietal lobule (SPL), right (CRBL). networks showed same fixed effective connectivity, with pathways V1, CRBL, SMAPMC CC wired closed loop. However, cerebellar communication towards switched from excitatory inhibitory AO. Moreover, only, signal modulation was non-linear CRBL within self-connection, supporting role of elaborating plans received SMAPMC. Thus, need for planning presence feedback discriminate modality forward control operated by on While underlying circuit mechanisms remain be determined, these results reveal differentially controls excitatory/inhibitory dynamics inter-regional connectivity depending its engagement, opening new prospective design artificial controllers investigation neurological diseases.

Language: Английский

Citations

0
Maternal Immune Activation and Peripubertal Stress Synergistically Disrupt Cerebellar Plasticity Integration and Impair Motor Coordination Learning DOI
Momoka Hikosaka, Nobutake Hosoi,

Myung-Si Yang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Exploring the Effects of ITBS Intervention on Rat Cerebellar Neural Oscillations and its Neural Mechanisms DOI
Tianling Wang, Xue Yang, Shuxian Zhang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells DOI Creative Commons
Francesca Prestori,

Eleonora Pali,

Stefano Masoli

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Cerebellar Golgi cells (GoCs) segregate parallel fiber (pf) and mossy (mf) inputs on apical basal dendrites. Computational modelling predicted that this anatomical arrangement, coupled with a specific ionic channel localization, could be instrumental to drive spike-timing dependent plasticity (STDP) at mf-GoC synapses. Here, we have tested hypothesis GoC patch-clamp recordings in acute mouse cerebellar slices. Indeed, repeated mf-pf pairing the theta-band (1 Hz

Language: Английский

Citations

0
Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex DOI Creative Commons
Simon Bossi,

Hervé Daniel,

Heather Mclean

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 15, 2024

The synapses between parallel fibers and Purkinje cells play a pivotal role in cerebellar function. They are intricately governed by variety of presynaptic receptors, notably type 4 metabotropic glutamate (mGlu4) receptors 1 adenosine (A1) both which curtail release upon activation. Despite their regulating synaptic transmission within the cortex, functional interactions mGlu4 A1 have remained relatively unexplored. To bridge this gap, our study delves into how receptor activity influences receptor-mediated alterations excitatory transmission. Employing combination whole-cell patch clamp recordings fiber fluorometric calcium measurements acute rat mouse cortical slices, results reveal these types. These findings hold implications for understanding potential roles neuroprotection during pathophysiological conditions characterized elevated levels.

Language: Английский

Citations

0
Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning DOI Creative Commons
Alice Geminiani, Claudia Casellato,

H-J Boele

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 23, 2023

Abstract According to Marr’s motor learning theory, plasticity at the parallel fibre Purkinje cells synapse ( pf -PC) is main substrate responsible for sensorimotor contingencies under climbing control. However, discovery of multiple forms distributed over different cerebellar circuit synapses prompts remap sites. Here, we have simulated classical eyeblink conditioning (CEBC) using an advanced spiking model embedding upbound and downbound modules that are subject rules. Simulations show synaptic regulates cascade precise patterns spreading throughout cortex nuclei. CEBC was supported by in both -PC feedforward inhibitory loop passing through molecular layer interneurons (MLIs), but only combined switch-off sites compromised significantly. By differentially engaging information related plasticity, contributed generate a well-timed conditioned response, it module played major role this process. The outcomes our simulations closely align with behavioural electrophysiological phenotypes mutant mice suffering from cell-specific mutations affect processing their PC or MLI synapses. Our data highlight synergy bidirectional rules across cerebellum facilitate finetuning adaptive associative behaviours high spatiotemporal resolution.

Language: Английский

Citations

0