Pancreatic
cancer
is
an
extremely
deadly
illness
for
which
there
are
few
reliable
treatments.
Recent
research
indicates
that
malignant
tumors
highly
variable
and
consist
of
a
tiny
subset
unique
cells,
known
as
stem
cells
(CSCs),
responsible
the
beginning
spread
tumors.
These
typically
identified
by
expression
specific
cell
surface
markers.
A
population
pancreatic
with
aberrantly
active
developmental
signaling
pathways
has
been
in
recent
studies
human
Among
these
Notch
pathway
key
regulator
CSCs
self-renewal,
making
it
attractive
target
therapeutic
intervention.
Chrysin-loaded
polylactic
acid
(PLA)
polymeric
nanoparticles
systems
have
growing
interest
using
platforms
improved
drug
delivery.
This
review
aims
to
explore
innovative
strategies
targeted
therapy
optimized
delivery
manipulating
leveraging
PLA-based
systems.
Furthermore,
we
will
assess
capability
PLA
enhance
bioavailability
effectiveness
gemcitabine
cells.
The
insights
gained
from
this
potential
contribute
development
novel
treatment
approaches
combine
advanced
utilizing
biodegradable
nanoparticles.
Cells,
Год журнала:
2022,
Номер
11(3), С. 342 - 342
Опубликована: Янв. 20, 2022
Cardiovascular
diseases
(CVDs)
contribute
to
a
large
part
of
worldwide
mortality.
Similarly,
two
the
major
risk
factors
for
these
diseases,
aging
and
obesity,
are
also
global
problems.
Aging,
gradual
decline
body
functions,
is
non-modifiable.
Obesity,
modifiable
factor
CVDs,
predisposes
type
2
diabetes
mellitus
(T2DM).
Moreover,
it
affects
not
only
vasculature
heart
but
specific
fat
depots,
which
themselves
have
impact
on
development
progression
CVDs.
Common
denominators
aging,
T2DM
include
oxidative
stress,
mitochondrial
dysfunction,
metabolic
abnormalities
such
as
altered
lipid
profiles
glucose
metabolism,
inflammation.
Several
plant
substances
curcumin,
active
compound
in
turmeric
root,
been
used
long
time
traditional
medicine
treatment
Newer
mechanistic,
animal,
human
studies
provide
evidence
that
curcumin
has
pleiotropic
effects
attenuates
numerous
parameters
an
increased
CVDs
well
obesity.
Thus,
nutraceutical
could
hold
promise
prevention
more
standardized
clinical
trials
required
fully
unravel
its
potential.
Immunity,
Год журнала:
2022,
Номер
55(2), С. 210 - 223
Опубликована: Фев. 1, 2022
Nutrition
affects
all
physiological
processes
including
those
linked
to
the
development
and
function
of
our
immune
system.
Here,
we
discuss
recent
evidence
emerging
concepts
supporting
idea
that
newfound
relationship
with
nutrition
in
industrialized
countries
has
fundamentally
altered
way
which
system
is
wired.
This
will
be
examined
through
lens
studies
showing
mild
or
transient
reductions
dietary
intake
can
enhance
protective
immunity
while
also
limiting
aberrant
inflammatory
responses.
We
further
how
trade-offs
priorities
begin
emerge
context
severe
nutritional
stress.
In
settings,
specific
immunological
functions
are
heightened
re-enforce
tissue
sites
most
critical
survival.
Altogether,
these
examples
emphasize
profound
influence
over
highlight
a
mechanistic
exploration
this
cross
talk
could
ultimately
lead
design
novel
therapeutic
approaches
prevent
treat
disease.
Cell Metabolism,
Год журнала:
2024,
Номер
36(8), С. 1779 - 1794.e4
Опубликована: Июль 25, 2024
Although
fasting
is
increasingly
applied
for
disease
prevention
and
treatment,
consensus
on
terminology
lacking.
Using
Delphi
methodology,
an
international,
multidisciplinary
panel
of
researchers
clinicians
standardized
definitions
various
approaches
in
humans.
Five
online
surveys
a
live
conference
were
conducted
with
38
experts,
25
whom
completed
all
5
surveys.
Consensus
was
achieved
the
following
terms:
"fasting"
(voluntary
abstinence
from
some
or
foods
beverages),
"modified
fasting"
(restriction
energy
intake
to
max.
25%
needs),
"fluid-only
fasting,"
"alternate-day
"short-term
(lasting
2-3
days),
"prolonged
(≥4
consecutive
"religious
fasting."
"Intermittent
(repetitive
periods
lasting
≤48
h),
"time-restricted
eating,"
"fasting-mimicking
diet"
discussed
most.
This
study
provides
expert
recommendations
future
research
clinical
applications,
facilitating
communication
cross-referencing
field.
Molecules,
Год журнала:
2021,
Номер
26(21), С. 6456 - 6456
Опубликована: Окт. 26, 2021
Chrysin,
a
herbal
bioactive
molecule,
exerts
plethora
of
pharmacological
effects,
including
anti-oxidant,
anti-inflammatory,
neuroprotective,
and
anti-cancer.
A
growing
body
evidence
has
highlighted
the
emerging
role
chrysin
in
variety
neurological
disorders,
Alzheimer’s
Parkinson’s
disease,
epilepsy,
multiple
sclerosis,
ischemic
stroke,
traumatic
brain
injury,
tumors.
Based
on
results
recent
pre-clinical
studies
from
humans,
this
review
is
focused
molecular
mechanisms
underlying
neuroprotective
effects
different
diseases.
In
addition,
potential
challenges,
opportunities
chrysin’s
inclusion
neurotherapeutics
repertoire
are
critically
discussed.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(20), С. 12325 - 12325
Опубликована: Окт. 14, 2022
Caloric
restriction
promotes
longevity
in
multiple
animal
models.
Compounds
modulating
nutrient-sensing
pathways
have
been
suggested
to
reproduce
part
of
the
beneficial
effect
caloric
on
aging.
However,
none
commonly
studied
mimetics
actually
produce
a
decrease
calories.
Sodium-glucose
cotransporter
2
inhibitors
(SGLT2-i)
are
class
drugs
which
lower
glucose
by
promoting
its
elimination
through
urine,
thus
inducing
net
loss
This
metabolic
shift
at
systemic
level,
fostering
ketones
and
fatty
acids
utilization
as
glucose-alternative
substrates,
is
accompanied
modulation
major
held
drive
aging,
e.g.,
mTOR
inflammasome,
overall
resembling
features
restriction.
In
addition,
preliminary
experimental
data
suggest
that
SGLT-2i
might
also
intrinsic
activities
independent
their
effects,
such
inhibition
cellular
senescence.
Consistently,
evidence
from
both
preclinical
clinical
studies
marked
ability
ameliorate
low-grade
inflammation
humans,
relevant
driver
aging
referred
inflammaging.
Considering
amount
trials,
observational
studies,
meta-analyses
suggesting
tangible
age-related
outcomes,
cardiovascular
diseases,
heart
failure,
kidney
disease,
all-cause
mortality
patients
without
diabetes,
here
we
propose
framework
where
least
benefit
provided
mediated
blunt
drivers
To
support
this
postulate,
synthesize
available
relative
on:
1-
models
healthspan
lifespan;
2-
selected
molecular
pillars
models;
3-
biomarkers
especially
inflammaging
humans;
4-
COVID-19-related
outcomes.
The
burden
prompt
design
testing
potential
employment
anti-aging
drugs.
