Journal of Inherited Metabolic Disease, Год журнала: 2025, Номер 48(1)
Опубликована: Янв. 1, 2025
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102066 - 102066
Опубликована: Сен. 7, 2023
Язык: Английский
Процитировано
65
Trends in Cell Biology, Год журнала: 2023, Номер 33(9), С. 788 - 802
Опубликована: Март 5, 2023
Autophagy is an intracellular degradation pathway that recycles subcellular components to maintain metabolic homeostasis. NAD essential metabolite participates in energy metabolism and serves as a substrate for series of NAD+-consuming enzymes (NADases), including PARPs SIRTs. Declining levels autophagic activity represent features cellular ageing, consequently enhancing either significantly extends health/lifespan animals normalises cells. Mechanistically, it has been shown NADases can directly regulate autophagy mitochondrial quality control. Conversely, preserve by modulating stress. In this review we highlight the mechanisms underlying bidirectional relationship between autophagy, potential therapeutic targets provides combatting age-related disease promoting longevity.
Язык: Английский
Процитировано
56
Nature Cell Biology, Год журнала: 2024, Номер 26(9), С. 1571 - 1584
Опубликована: Авг. 8, 2024
Abstract Caloric restriction and intermittent fasting prolong the lifespan healthspan of model organisms improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection reduced incidence cardiovascular neurodegenerative diseases across species borders. Here, we asked whether cellular physiological consequences caloric depend on metabolism. We report that levels increased upon distinct regimens or in yeast, flies, mice volunteers. Genetic pharmacological blockade endogenous synthesis fasting-induced nematodes cells. Furthermore, perturbing pathway vivo abrogated lifespan- healthspan-extending effects, as well cardioprotective anti-arthritic fasting. Mechanistically, mediated these effects via induction hypusination translation regulator eIF5A. In summary, polyamine–hypusination axis emerges a phylogenetically conserved metabolic control hub for fasting-mediated enhancement longevity.
Язык: Английский
Процитировано
31
Frontiers in Molecular Biosciences, Год журнала: 2025, Номер 11
Опубликована: Янв. 28, 2025
Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy progression age-related decline. As organisms age, cellular stress, genomic instability, an accumulation senescent cells create a pro-inflammatory environment conducive to development. Autophagy, process responsible for degrading recycling damaged components, plays pivotal role in this relationship. While autophagy acts as tumor-suppressive mechanism by preventing organelles proteins, often exploit it survive under conditions metabolic stress treatment resistance. The interplay between aging, cancer, reveals key insights into tumorigenesis, senescence, proteostasis dysfunction. This review explores connections these processes, emphasizing potential autophagy-targeted therapies strategies could be further explored aging treatment. Understanding dual roles suppressing promoting offers promising avenues therapeutic interventions aimed at improving outcomes elderly patients while addressing deterioration.
Язык: Английский
Процитировано
2
The Annual Review of Pharmacology and Toxicology, Год журнала: 2023, Номер 64(1), С. 339 - 357
Опубликована: Авг. 16, 2023
Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance tissue homeostasis, resolution inflammation, and repair. However, impaired efferocytosis can result in accumulation cells, subsequently triggering sterile inflammation through release endogenous factors such DNA nuclear proteins from membrane permeabilized dying cells. Here, we review molecular basis three phases that is, detection, uptake, degradation materials phagocytes. We also discuss how defects due to alteration phagocytes contribute low-grade chronic occurs during aging, described inflammaging. Lastly, explore opportunities targeting harnessing efferocytic machinery limit aging-associated inflammatory diseases.
Язык: Английский
Процитировано
25
Seminars in Cancer Biology, Год журнала: 2024, Номер 99, С. 24 - 44
Опубликована: Фев. 1, 2024
Autophagy, a self-degradative process vital for cellular homeostasis, plays significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, cancer development, with specific emphasis on how obesity-driven changes affect regulation of autophagy subsequent implications risk. The burgeoning epidemic obesity underscores relevance this research, particularly given established links various cancers. Our exploration delves into hormonal influence, notably INS (insulin) LEP (leptin), interactions. Further, we draw attention latest findings molecular factors linking cancer, including changes, altered metabolism, secretory autophagy. We posit that targeting modulation may offer potent therapeutic approach obesity-associated pointing promising advancements nanocarrier-based targeted therapies modulation. However, also recognize challenges inherent these approaches, concerning their precision, control, dual roles can play cancer. Future research directions include identifying novel biomarkers, refining therapies, harmonizing approaches precision medicine principles, thereby contributing more personalized, effective treatment paradigm obesity-mediated
Язык: Английский
Процитировано
15
American Journal Of Pathology, Год журнала: 2024, Номер 194(4), С. 510 - 524
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
9
Cell Metabolism, Год журнала: 2024, Номер 36(9), С. 1945 - 1962
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
9
Seminars in Immunopathology, Год журнала: 2025, Номер 47(1)
Опубликована: Янв. 21, 2025
The intestinal epithelium is a rapidly self-renewing tissue; the rapid turnover prevents invasion of pathogens and harmful components from lumen, preventing inflammation infectious diseases. Intestinal epithelial barrier function depends on cell proliferation junctions, as well state immune system in lamina propria. Polyamines, particularly putrescine, spermidine, spermine, are essential for many functions play crucial role mammalian cellular homeostasis, such that growth, proliferation, differentiation, maintenance, through multiple biological processes, including translation, transcription, autophagy. Although vital polyamines normal growth has been known since 1980s, recent studies have provided new insights into this topic at molecular level, eukaryotic initiation factor-5A hypusination autophagy, with advances polyamine biology cells using technologies. This review summarizes our understanding regulating normal, non-cancerous, function, particular focus renewal, differentiation
Язык: Английский
Процитировано
1
Nucleic Acids Research, Год журнала: 2024, Номер 52(6), С. 3031 - 3049
Опубликована: Янв. 28, 2024
Abstract Histone variants are key epigenetic players, but their functional and physiological roles remain poorly understood. Here, we show that depletion of the histone variant H2A.Z in mouse skeletal muscle causes oxidative stress, oxidation proteins, accumulation DNA damages, both neuromuscular junction mitochondria lesions consequently lead to premature aging reduced life span. Investigation molecular mechanisms involved shows is required initiate double strand break repair by recruiting Ku80 at lesions. This achieved via specific interactions vWA domain with H2A.Z. Taken as a whole, our data reveal containing nucleosomes act platform bring together proteins process repair.
Язык: Английский
Процитировано
7