International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 6959 - 6959
Опубликована: Апрель 9, 2023
Asthma
is
a
heterogeneous
inflammatory
disease
characterized
by
abnormalities
in
immune
response.
Due
to
the
inherent
complexity
of
and
presence
comorbidities,
asthma
control
often
difficult
obtain.
In
asthmatic
patients,
an
increased
prevalence
irregular
menstrual
cycles,
infertility,
obesity,
insulin
resistance
has
been
reported.
Given
that
these
conditions
are
also
common
patients
with
polycystic
ovary
syndrome
(PCOS),
we
propose
definition
“asthma-PCOS
overlap
syndrome”
indicate
medical
condition
which
shares
characteristics
both
diseases.
The
aim
this
review
analyze
links
between
PCOS
evaluate
therapeutic
role
myo-inositol,
natural
compound
currently
utilized
PCOS,
management
patients.
Cells,
Год журнала:
2023,
Номер
12(1), С. 184 - 184
Опубликована: Янв. 2, 2023
Immune
cells
and
commensal
microbes
in
the
human
intestine
constantly
communicate
with
react
to
each
other
a
stable
environment
order
maintain
healthy
immune
activities.
system-microbiota
cross-talk
relies
on
complex
network
of
pathways
that
sustain
balance
between
tolerance
immunogenicity.
Probiotic
bacteria
can
interact
stimulate
intestinal
microflora
modulate
specific
functions
homeostasis.
Growing
evidence
shows
probiotic
present
important
health-promoting
immunomodulatory
properties.
Thus,
use
probiotics
might
represent
promising
approach
for
improving
system
So
far,
few
studies
have
been
reported
beneficial
modulatory
effect
probiotics.
However,
many
others,
which
are
mainly
focused
their
metabolic/nutritional
properties,
published.
Therefore,
mechanisms
behind
interaction
host
only
partially
described.
The
review
aims
collect
summarize
most
recent
scientific
results
resulting
implications
how
improve
functions.
Hence,
description
currently
known
is
provided.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(10), С. 5466 - 5466
Опубликована: Май 13, 2022
Engineered
probiotics
represent
a
cutting-edge
therapy
in
intestinal
inflammatory
disease
(IBD).
Genetically
modified
bacteria
have
provided
new
strategy
to
release
therapeutically
operative
molecules
the
intestine
and
grown
into
promising
therapies
for
IBD.
Current
IBD
treatments,
such
as
corticosteroids
immunosuppressants,
are
associated
with
relevant
side
effects
significant
proportion
of
patients
dependent
on
these
therapies,
thus
exposing
them
risk
long-term
effects.
Discovering
effective
therapeutic
strategies
is
worldwide
goal
this
research
field
engineered
could
potentially
provide
viable
solution.
This
review
aims
at
describing
proceeding
bacterial
engineering
how
genetically
may
biotechnological
approach
treatment.
Current Nutrition Reports,
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 7, 2023
Abstract
Purpose
of
Review
The
aim
this
review
is
to
provide
an
overview
the
menopause-related
changes
in
microbiota
and
their
role
pathogenesis
diseases.
In
addition,
evidence
on
probiotic
supplementation
as
a
therapeutic
strategy
discussed.
Recent
Findings
human
complex
community
that
lives
mutualism
relationship
with
host.
Menopause
associated
dysbiosis,
these
composition
different
sites
(gut,
vaginal,
oral
microbiota)
might
play
diseases
(i.e.,
osteoporosis,
breast
cancer,
endometrial
hyperplasia,
periodontitis,
cardiometabolic
diseases).
Summary
present
highlights
pivotal
postmenopausal
women
health,
particular
it
(a)
may
increase
intestinal
calcium
absorption
thus
preventing
(b)
reduced
risk
cancer
type
1
(c)
reduces
gingival
inflammation
menopausal
(d)
beneficially
affects
multiple
factors
obesity,
inflammation,
blood
glucose
lipid
metabolism).
However,
whether
be
used
for
treatment
dysbiosis
requires
further
clarification.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
10
Опубликована: Янв. 15, 2024
Background
Currently,
the
prevalence
of
allergic
rhinitis
(AR)
remains
high
and
there
is
a
great
need
to
develop
better
safer
ways
alleviate
AR
symptoms.
The
Lactobacillus
plantarum
GUANKE
probiotic
was
reported
as
an
immunomodulator
through
maintaining
Th1/Th2
balance.
This
study
aimed
determine
efficacy
in
subjects.
Methods
Adults
aged
from
18
60
years
old
previously
suffered
were
recruited
received
probiotics
treatment
for
4
weeks.
questionnaires
Total
nasal
symptom
scores
(TNSS),
total
non-nasal
score
(TNNSS),
control
assessment
test
(RCAT)
used
assess
effectiveness
before
after
treatment.
serum
allergen-specific
IgE
cytokines
also
determined
at
baseline
weeks
administration.
Results
results
showed
that
TNSS
TNNSS
significantly
reduced
RCAT
increased
compared
baseline.
sub-symptom
rhinorrhea,
itching,
sneezing,
tearing
each
questionnaire
significant
changes,
level
markedly
decreased.
We
further
measured
inflammatory-related
proteins
found
20
(6
upregulated
14
downregulated)
changed
baseline,
including
IL-4,
IL-7,
IL-20,
IL-33,
CXCL1,
CXCL5,
CXCL6,
CXCL11,
CCL4,
CCL23,
TGF-alpha,
LAP-TGF-beta-1,
MMP-1,
MMP-10,
AXIN1,
NT-3,
OSM,
SCF,
CD6,
NRTN.
Enrichment
analysis
these
altered
mainly
enriched
cytokine
chemokine-related
signaling
pathways.
Conclusion
Taken
together,
this
demonstrated
can
serve
effective
immunobiotic
AR,
which
realized
balance
by
modulating
functions
various
chemokines.
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29499 - e29499
Опубликована: Апрель 1, 2024
Lacticaseibacillus
rhamnosus
is
a
group
of
probiotic
strains
that
have
gained
popularity
for
their
potential
health
benefits
such
as
promoting
digestive
health,
boosting
the
immune
system,
improving
lactose
digestion,
preventing
and
treating
antibiotic-associated
diarrhea,
reducing
severity
duration
certain
infections,
formation
dental
plaque.
In
particular,
L.
SD4
SD11
promising
human
animal
applications
due
to
ability
inhibit
growth
harmful
pathogens.
This
study
presents
an
in
silico
genomic
analysis
SD11.
We
analyzed
draft
genomes
conducted
comparative
genome
analyses
against
several
other
strains,
aiming
gain
insights
into
two
compare
them
related
isolated
from
sources.
also
aimed
clarify
functional
mechanisms
adaptation
these
specific
environments.
Comprehensive
could
enhance
our
understanding
capacity
colonize,
adapt,
exhibit
properties
after
administration.
holds
significance
advancing
associated
with
elucidating
underlying
responsible
effectiveness
humans
animals.
Journal of Asthma and Allergy,
Год журнала:
2022,
Номер
Volume 15, С. 1413 - 1428
Опубликована: Окт. 1, 2022
Allergic
rhinitis
(AR)
impairs
the
quality
of
life
patients
and
reduces
efficiency
social
work,
it
is
an
increasingly
serious
public
medical
economic
problem
in
world.
Conventional
anti-allergic
drugs
for
treatment
allergic
can
cause
certain
side
effects,
which
limit
patients.
Therefore,
makes
sense
to
look
other
forms
treatment.
Several
studies
recent
years
have
shown
that
probiotics
effects
various
mouse
human
studies.
For
example,
application
probiotic
strains
effectively
relieve
typical
nasal
ocular
symptoms
children
adults,
thereby
improving
work
efficiency.
At
same
time,
previous
humans
mice
found
produce
multiple
such
as
reduction
Th2
cell
inflammatory
factors
and/or
increase
Th1
factors,
changes
allergy-related
immunoglobulins
migration,
regulate
Th1/Th2
balance
or
restore
intestinal
microbiota
disturbance.
with
limited
activity
more
attacks
longer
attack
duration,
oral
positive
effects.
The
efficacy
prevention
remarkable,
but
its
specific
mechanism
needs
further
study.
This
review
summarizes
research
progress
years.
Children,
Год журнала:
2022,
Номер
9(7), С. 978 - 978
Опубликована: Июнь 29, 2022
A
type-2
immune
response
usually
sustains
wheezing
and
asthma
in
children.
In
addition,
dysbiosis
of
digestive
respiratory
tracts
is
detectable
patients
with
asthma.
Probiotics
may
rebalance
response,
repair
dysbiosis,
mitigate
airway
inflammation.
As
a
result,
probiotics
prevent
relapse.
There
evidence
that
some
probiotic
strains
improve
outcomes
this
context,
the
PROPAM
study
provided
two
specific
significantly
prevented
exacerbations
episodes.
Therefore,
oral
could
be
used
as
add-on
therapy
managing
children
asthma,
but
choice
should
based
on
documented
evidence.
