Food Research International, Год журнала: 2024, Номер 197, С. 115234 - 115234
Опубликована: Окт. 22, 2024
Язык: Английский
Drugs, Год журнала: 2023, Номер 83(16), С. 1501 - 1521
Опубликована: Окт. 11, 2023
Язык: Английский
Процитировано
33
Journal of Advanced Research, Год журнала: 2024, Номер unknown
Опубликована: Апрель 1, 2024
It is estimated that 90% of hyperuricemia cases are attributed to the inability excrete uric acid (UA). The two main organs in charge excreting UA kidney (70%) and intestine (30%). Previous studies have reported punicalagin (PU) could protect against intestinal damages, which makes it a potential candidate for alleviating hyperuricemia. However, effects deeper action mechanisms PU managing still unknown. To investigate effect ameliorating on were assessed using mice model. Phenotypic parameters, metabolomics analysis, 16S rRNA sequencing applied explore fundamental inside improving administration significantly decreased elevated serum (SUA) levels mice, effectively alleviated damage caused by In kidney, down-regulated expression resorption protein URAT1 GLUT9, while up-regulating excretion ABCG2 OAT1 as mediated via activation MAKP/NF-κB mice. Additionally, attenuated renal glycometabolism disorder, contributed dysfunction inflammation. Similarly, increased inhibiting Furthermore, restored gut microbiota dysbiosis This research revealed impacts restoring be considered development nutraceuticals used UA-lowering agent.
Язык: Английский
Процитировано
12
npj Biofilms and Microbiomes, Год журнала: 2024, Номер 10(1)
Опубликована: Март 20, 2024
Abstract Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted relationship between the gut microbiota and gout, whether could ameliorate HUA-associated systemic metabolism remains unclear. In this study, we constructed novel model of HUA in geese investigated mechanism which Lactobacillus rhamnosus GG (LGG) beneficial effects on HUA. The administration antibiotics fecal transplantation (FMT) experiments were used goose model. LGG its metabolites evaluated vivo vitro. Heterogeneous expression gene knockout revealed LGG. Multi-omics analysis that genus associated with changes This study showed alleviate through gut-liver-kidney axis. Whole-genome analysis, heterogeneous expression, enzymes ABC-type multidrug transport system ( ABCT ), inosine-uridine nucleoside N-ribohydrolase iunH xanthine permease pbuX ) demonstrated function degradation correlation patients serum proline deficiency, as well Collinsella , may be occurrence Our findings potential diet-induced HUA, promising therapies for
Язык: Английский
Процитировано
10
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Фев. 1, 2024
Gut microbiota is an important modulator of human health and contributes to high inter-individual variation in response food pharmaceutical ingredients. The clinical outcomes interventions with prebiotics, probiotics, synbiotics have been mixed often unpredictable, arguing for novel approaches developing microbiome-targeted therapeutics. Here, we review how the gut determines fate individual responses dietary xenobiotic compounds via its immense metabolic potential. We highlight that microbial metabolites play a crucial role as targetable mediators microbiota-host relationship. With this mind, expand concept beyond prebiotics' facilitating growth engraftment by focusing on metabolism vital mode action thereof. Consequently, discuss synbiotic compositions enable guided or co-formulated ingredients specific microbes leading target molecules beneficial functions. A workflow develop presented, including selection promising (e.g. equol, urolithin A, spermidine, indole-3 derivatives), identification suitable substrates producer strains applying bioinformatic tools, models, eventually trials.
Язык: Английский
Процитировано
8
Food & Function, Год журнала: 2024, Номер 15(11), С. 6068 - 6081
Опубликована: Янв. 1, 2024
Epigallocatechin gallate (EGCG), a prominent bioactive compound found in tea, offers numerous health benefits. Previous studies have highlighted its potential mitigating hyperuricemia. In this study, hyperuricemic mice induced by potassium oxonate (PO) were treated with EGCG or the anti-hyperuricemia medication allopurinol (AP) to investigate mechanisms underlying their anti-hyperuricemic effects. The results demonstrated that both and AP significantly reduced serum uric acid (UA) levels. Further analysis revealed promoted expression of UA secretion transporter genes (
Язык: Английский
Процитировано
8
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114532 - 114532
Опубликована: Март 14, 2023
The incidence of hyperuricemia and gout has been increasing year by year, it is showing a younger trend. However, the first-line drugs currently used for gouty arthritis have serious side effects that limit their clinical application. Amomum villosum Lour. widely in China thousands years as traditional medical edible plant, previous screening showed ethanol extract could effectively inhibit activity xanthine oxidase. Based on this discovery, paper had achieved in-depth mechanism research. results treat reducing production uric acid via inhibition oxidase excretion regulation urate transporters. Meanwhile, also certain protective effect hepatic renal damage caused hyperuricemia. With formation extensive acid, will be induced deposition monosodium joint. relieve inflammation expression inflammatory cytokines. In conclusion, deserves focused research development potential medicine, health care product or supplemented food prevention treatment arthritis.
Язык: Английский
Процитировано
13
Microorganisms, Год журнала: 2024, Номер 12(4), С. 637 - 637
Опубликована: Март 22, 2024
Hyperuricemia is a prevalent metabolic disorder that arises from abnormal purine metabolism and reduced excretion of uric acid (UA). The gut microbiota plays significant role in the biosynthesis UA. Probiotics capable degradation possess potential to prevent hyperuricemia. Our study aimed screen probiotics areas with abundant dairy products longevity populations China, which could attenuate level UA explore underlying mechanism. In this study, twenty-three lactic bacteria isolated healthy Chinese infant feces traditional fermented foods such as hurood lump milk were evaluated for ability tolerance acid, bile, artificial gastric juice, intestinal juice determine candidate strains probiotics. Eight identified possessing superior simulated conditions further analyzed by high-performance liquid chromatography (HPLC), revealing Limosilactobacillus reuteri HCS02-001 (Lact-1) Lacticaseibacillus paracasei HCS17-040 (Lact-2) most potent degrade nucleosides. effect Lact-1 Lact-2 on hyperuricemia was intervening them potassium oxonate adenine-induced Balb/c mice model vivo. results showed serum hyperuricemic can be efficiently via oral administration (p < 0.05). It significantly inhibited levels liver inflammatory cytokines hepatic xanthine oxidase through TLR4/MyD88/NF-κB pathway across gut–liver axis. Furthermore, transporters ABCG2 SLC2A9 substantially upregulated intervention probiotic. Fecal ATP induced, while fecal dehydrogenase allantoinase increased following RNA sequencing HT-29 cells line treated its metabolites demonstrated regulation pathways related summary, these findings demonstrate possesses capacity ameliorate inhibiting enhancing gastrointestinal barrier functions promoting removal upregulation urate transporters, thereby providing basis probiotic formulation targeting microbiota.
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116859 - 116859
Опубликована: Июнь 15, 2024
Phellinus igniarius is an important medicinal and edible fungus with diverse biological activities. This study aimed to investigate the effects of aqueous extract from P. (API) on treatment hyperuricemia (HUA) related kidney damage. The chemical constituents API were determined. therapeutic HUA renal injury assessed in adenine/potassium oxonate (PO)-treated mice. constituent analysis revealed a predominance polysaccharides (33.4 %), followed by total flavonoids (9.1 triterpenoids (3.5 %). Compared control, adenine/PO greatly elevated serum uric acid (UA) levels but this elevation was attenuated API. In liver, expression activity xanthine oxidase (XOD) increased which diminished Furthermore, found enhance UA transporter ABCG2 intestine mice, suggesting elevating excretion. Additionally, ameliorated HUA-induced injury, as indicated reduced BUN/creatinine levels, decreased glomerular tubular damage, lowered fibrotic levels. Network pharmacology predicted that may regulate mitochondrial function improve HUA-related injury. prediction then substantialized API-induced upregulation NAD+/NADH ratio, ATP level, SOD2 activity, SOD2/PCG-1α/PPARγ Our results demonstrate effectively ameliorate reducing production liver enhancing excretion intestine, it might be potential therapy
Язык: Английский
Процитировано
5
Frontiers in Pediatrics, Год журнала: 2025, Номер 13
Опубликована: Фев. 6, 2025
Recurrent respiratory tract infections (RRTIs) are a common condition in pediatrics and significantly impact children's quality of life; however, their pathogenesis contributing factors not yet fully elucidated. Probiotics have recently emerged as promising agents for modulating intestinal microecology gained considerable attention clinical research on preventing treating RRTIs children. This article provides an initial overview the concept, classification, mechanisms underlying probiotics. It emphasizes beneficial effects health by microbial equilibrium, augmenting immune system functionality, attenuating inflammatory responses. Subsequently, we examine existing regarding use probiotics pediatric RRTIs. Numerous trials unequivocally demonstrated that supplementing with can reduce both frequency severity children while also simultaneously decreasing antibiotic usage. However, there ongoing controversies challenges current concerning influence probiotic type, dosage, duration use, other efficacy. Furthermore, variations been observed across different studies. Additionally, it is crucial to further evaluate safety potential long-term side associated In conclusion, propose future directions including conducting more high-quality randomized controlled optimize application strategies alongside treatments considering based age conditions among populations. Finally, summary although exhibit benefits children; additional studies necessary refine ensuring effectiveness.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123529 - 123529
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0