Efficacy and safety of a mineral and vitamin treatment on symptoms of antenatal depression: 12-week fully blinded randomised placebo-controlled trial (NUTRIMUM)

BJPsych Open, Год журнала: 2024, Номер 10(4)

Опубликована: Июнь 3, 2024

Background Broad-spectrum micronutrients (minerals and vitamins) have shown benefit for treatment of depressive symptoms. Aims To determine whether additional reduce symptoms antenatal depression. Method Eighty-eight medication-free pregnant women at 12–24 weeks gestation, who scored ≥13 on the Edinburgh Postnatal Depression Scale (EPDS), were randomised 1:1 to or active placebo (containing iodine riboflavin), 12 weeks. Micronutrient doses generally between recommended dietary allowance tolerable upper level. Primary outcomes (EPDS Clinical Global Impression – Improvement (CGI-I)) analysed with constrained longitudinal data analysis. Results Seventeen (19%) dropped out, no group differences, four (4.5%) gave birth before trial completion. Both groups improved EPDS, differences ( P = 0.1018); 77.3% taking 72.7% placebos considered recovered. However, micronutrient demonstrated significantly greater improvement, based CGI-I clinician ratings, over time 0.0196). The had improvement sleep global assessment functioning, more likely identify themselves as ‘much’ ‘very much’ (68.8%) compared (38.5%) (odds ratio 3.52, 0.011; number needed treat: 3). There significant treatment-emergent adverse events, including suicidal ideation. Homocysteine decreased in group. Presence personality difficulties, history psychiatric medication use higher social support tended increase response placebo. Conclusions This study highlights benefits monitoring depression, added efficacy overall functioning when micronutrients, evidence harm. Trial replication larger samples clinically diagnosed depression are needed.

Язык: Английский

Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression

Journal of Clinical Psychopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 2, 2024

Purpose/Background One-fifth of women experience antenatal depression. Untreated depression is associated with increased risk adverse birth outcomes. This study investigated the effect broad-spectrum micronutrients (BSM; vitamins and minerals), used to treat (NUTRIMUM trial), on Methods/Procedures Birth outcomes 129 mother-infant pairs were obtained from hospital medical records or personal health for home births. Pairs NUTRIMUM exposed ≥8 weeks BSM antenatally (MN; n = 55) compared antidepressants (MED; 20) a reference group (REF; 54) not trial antidepressants. Findings/Results Groups comparable demographic variables. At entry, MN MED had scores in moderate range, statistically higher than REF (nonclinical range). did differ significantly gestational age, preterm births, infant size, resuscitation. There lower rates postpartum hemorrhage relative (7.7% vs 30%; RR 0.26, 95% CI [0.08–0.84]). Gestational age at was (39.5 weeks) (38.5 weeks; d 0.67, [0.15–1.20], P 0.03) as well length (52.2 50.0 cm; 0.77, [0.21–1.33], 0.02), resuscitation (14.5% 45%; 0.33, [0.15–0.73]). Days exposure positively weight ( r 0.32, 0.008) 0.25, 0.04). Implications/Conclusions Micronutrients alleviate may mitigate negative effects showed more favorable

Язык: Английский