Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Год журнала: 2025, Номер 10(2), С. 73 - 73

Опубликована: Янв. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Язык: Английский

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Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Nutrients, Год журнала: 2024, Номер 17(1), С. 143 - 143

Опубликована: Дек. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Язык: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Год журнала: 2025, Номер 13(2), С. 241 - 241

Опубликована: Янв. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Язык: Английский

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Screening for Selenomonas noxia in a Pediatric and Adolescent Patient Population Reveals Differential Oral Prevalence across Age Groups

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(4), С. 391 - 391

Опубликована: Март 23, 2024

Selenomonas noxia, a gram-negative anaerobe usually present in periodontitis, may be linked to overweight and obese adults. Recent advancements include valid qPCR screening, enabling an effective prevalence study among pediatric patients aged 7 17 years. The aim of this was complete retrospective screening saliva samples from existing biorepository using validated protocol. sample (n = 87) comprised nearly equal numbers males females, mostly minority (67%), with average age 13.2 Screening for noxia revealed 34.4% 30/87) positive samples, evenly distributed between females (p 0.5478). However, age-dependent association observed higher percentages ages (13.3% 10 years; 34.6% 11 13 54.8% 14–17 years), which statistically significant 0.0001). Although these findings no noteworthy distinctions or minorities non-minorities, the notable contrast younger (7 years) older (11 participants, possibly influenced by factors such as hormones behavioral traits, will require further investigation patient population.

Язык: Английский

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Intermittent fasting and high-intensity interval training do not alter gut microbiota composition in adult women with obesity.

AJP Endocrinology and Metabolism, Год журнала: 2024, Номер 327(3), С. E241 - E257

Опубликована: Июнь 26, 2024

This is the first investigation about alternate-day fasting combined with HITT on gut microbiota of obese women. The study contributes to advancement human science involving IF and HIIT, popular strategies for managing obesity. Previous evidence has explored in modulating animal models or specific populations clinical conditions. Despite subtle outcomes, this relevance originality field knowledge.

Язык: Английский

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Fasting: A Complex, Double-Edged Blade in the Battle Against Doxorubicin-Induced Cardiotoxicity

Cardiovascular Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Mind Over Microbes: Investigating the Interplay Between Lifestyle Factors, Gut Microbiota, and Brain Health

Neuroepidemiology, Год журнала: 2024, Номер unknown, С. 1 - 23

Опубликована: Март 26, 2024

<b><i>Background:</i></b> The gut microbiota (GM) of the human body comprises several species microorganisms. This microorganism plays a significant role in physiological and pathophysiological processes various diseases. <b><i>Methods:</i></b> literature review includes studies that describe causative factors influence GM. GM is sensitive to like circadian rhythms, environmental agents, physical activity, nutrition, hygiene together impact functioning composition microbiome. affects health host, including psycho-neural aspects, due interconnectivity between brain gut. Hence, this paper examines relationship with neurodegenerative disorders context these aforesaid factors. <b><i>Conclusion:</i></b> Future identify regulatory pathways associated microbes can provide causal link degeneration at molecular level. Together, could be helpful designing preventive treatment strategies aimed GM, so diseases treated.

Язык: Английский

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Time-restricted eating, the clock ticking behind the scenes

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 8, 2024

Maintaining metabolic balance relies on accumulating nutrients during feeding periods and their subsequent release fasting. In obesity disorders, strategies aimed at reducing food intake while simulating fasting have garnered significant attention for weight loss. Caloric restriction (CR) diets intermittent (IF) interventions emerged as effective approaches to improving cardiometabolic health. Although the comparative benefits of CR

Язык: Английский

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Fasting in Judo—Between Healthy Weight Control and Health Hazard: A Narrative Review

Obesities, Год журнала: 2024, Номер 4(4), С. 453 - 467

Опубликована: Ноя. 5, 2024

Rapid weight loss strategies and cycling (losing gaining repeatedly) are acknowledged problems in sports with categories, including judo. Extreme fasting, especially if combined dehydration intense physical exercise, may harm health development, particularly those of children teenagers engaging judo competitions. However, there is substantial evidence for positive effects other forms fasting. Here, we aim to provide an updated overview the potential risks associated extreme dietary contrast them health-promoting fasting approaches. We conclude that literature on long-term consequences scarce. This applies specifically its association eating disorders. Although many reports have highlighted short-term rapid loss, vulnerability protection factors remain poorly understood. Rigorous scientific studies needed disentangle render healthy or unhealthy, considering both mental health. argue a better understanding management crucial preventing designing strategies, young athletes.

Язык: Английский

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Circadian Deregulation: Back Facing the Sun Toward Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Development

Nutrients, Год журнала: 2024, Номер 16(24), С. 4294 - 4294

Опубликована: Дек. 12, 2024

Earth’s rotation around its axis has pressured inhabitants to adapt 24 h cycles of day and night. Humans adapted their own circadian rhythms the with a light-aligned awake–sleep cycle. As consequence, metabolism undergoes drastic changes throughout cycle needs plasticity cope opposing conditions in (when there is an increase energy demands food availability), during night prolonged fasting couples cyclic across sleep stages). In last century, human behavior changed dramatically disregard for natural cycles. This misalignment eating schedules strongly modulates homeostasis, favoring development obesity, metabolic syndrome, dysfunction-associated steatotic liver disease (MASLD). review summarizes effects disruption, particular focus on feeding MASLD hepatocellular carcinoma.

Язык: Английский

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