The Anti-AGEing and RAGEing Potential of Isothiocyanates DOI Creative Commons
Bradley A. Krisanits, Balpreet Kaur, Jed W. Fahey

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5986 - 5986

Published: Dec. 19, 2024

Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis precursors known glucosinolates. ITCs have been studied extensively both vivo and vitro to define their therapeutic potential for treatment chronic health conditions. Therapeutically, they shown an intrinsic ability inhibit oxidative inflammatory phenotypes support enhanced health. This review summarizes current evidence supporting observation that antioxidant anti-inflammatory activities temper pathogenic effects metabolites called advanced glycation end products (AGEs). AGE exposure has significantly increased across lifespan due risk factors include dietary intake, sedentary lifestyle, comorbid By contributing cycle stress through aberrant activation transmembrane receptor (RAGE), bioavailability is associated with disease onset, progression, severity. debates molecular mechanisms which may reduce RAGE-mediated pro-oxidant pro-inflammatory phenotypes. Bringing light impact on biogenesis stimulate novel intervention strategies reversing or preventing lifestyle risk.

Language: Английский

The Impact of Sulforaphane on Sex-Specific Conditions and Hormone Balance: A Comprehensive Review DOI Creative Commons
Jed W. Fahey,

Mirran Raphaely

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 522 - 522

Published: Jan. 8, 2025

The health-promoting, preventive, protective, and therapeutic applications of the natural compound sulforaphane (SF) produced from its biogenic precursor in broccoli, glucoraphanin, are extremely well established. SF has been subject thousands studies over 125 clinical trials. many mechanisms action mammalian systems have extensively documented. is most potent naturally occurring inducer Keap1/Nrf2 pathway, which well-known for upregulation antioxidant detoxification activation pathways resulting inhibition inflammation. Much this regulation involves various hormonal axes body. However, influence on hormone-mediated health conditions remains unexplored recent scholarly reviews. This review aims to address gap by exploring these interactions, with a focus wellness issues specific both females males.

Language: Английский

Citations

0
Effects of sulforaphane on ABC and SRS scales in patients with autism spectrum disorder: a meta-analysis DOI Creative Commons

Jialing Guo,

Yichao Wang,

Weijun He

et al.

Brain and Development, Journal Year: 2025, Volume and Issue: 47(2), P. 104321 - 104321

Published: Feb. 14, 2025

Language: Английский

Citations

0
Epigallocatechin -3- gallate mitigates diazinon neurotoxicity via suppression of pro-inflammatory genes and upregulation of antioxidant pathways DOI Creative Commons

Charles Etang Onukak,

Omowumi Femi‐Akinlosotu, Adedunsola A. Obasa

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 10, 2025

Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact humans and other non-target species remains an important public health concern. The study aimed investigate effect epigallocatechin -3- gallate (EGCG), abundant green tea plants on neurobehavioural, biochemical, pathological changes brain male Wistar rats following diazinon toxicity. Sixty adult were acclimatized seven days subsequently randomly assigned into six treatment groups as follows: Group I: Control group (0.2 mL distilled water); II: at 3 mg/kg (1% LD50); III: (3 mg/kg) + EGCG (50 mg/kg, ~ 2% IV: (100 5% V: VI: mg/kg). All treatments administered orally once daily 14 days. Neurobehavioural studies, biomarkers oxidative stress, histology, immunohistochemistry, quantitative polymerase chain reaction (RT qPCR) performed. alone impaired recognition memory, increased stress markers altered antioxidant defense brain. It upregulated TNF-α IL-6 genes repressed GPx 4 gene expressions. was also associated with GFAP, Tau, α-SN immunoreactivity. Microscopic examination revealed loss Purkinje hippocampal cells Co-treatment however improved cognition, lowered markers, status suppressed IL-6. In conclusion, findings from this demonstrated that offered protection against diazinon-induced neurotoxicity. Hence, natural sources such fruits vegetables could offer immense benefits by protecting inflammation neurodegenerative disease conditions. Clinical trial number Not applicable.

Language: Английский

Citations

0
Effects of Sulforaphane on Negative Symptoms and Cognitive Impairments in chronic Schizophrenia patients: A Randomized Double-Blind Trial DOI
Haiyu Chen,

Jinjun Lu,

Tianxiang Zou

et al.

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1353 - 1353

Published: April 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Language: Английский

Citations

0
The Anti-AGEing and RAGEing Potential of Isothiocyanates DOI Creative Commons
Bradley A. Krisanits, Balpreet Kaur, Jed W. Fahey

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5986 - 5986

Published: Dec. 19, 2024

Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis precursors known glucosinolates. ITCs have been studied extensively both vivo and vitro to define their therapeutic potential for treatment chronic health conditions. Therapeutically, they shown an intrinsic ability inhibit oxidative inflammatory phenotypes support enhanced health. This review summarizes current evidence supporting observation that antioxidant anti-inflammatory activities temper pathogenic effects metabolites called advanced glycation end products (AGEs). AGE exposure has significantly increased across lifespan due risk factors include dietary intake, sedentary lifestyle, comorbid By contributing cycle stress through aberrant activation transmembrane receptor (RAGE), bioavailability is associated with disease onset, progression, severity. debates molecular mechanisms which may reduce RAGE-mediated pro-oxidant pro-inflammatory phenotypes. Bringing light impact on biogenesis stimulate novel intervention strategies reversing or preventing lifestyle risk.

Language: Английский

Citations

1