Опубликована: Янв. 1, 2024
8-oxo-2-deoxiguanosina 8-oxo-dG: 8-oxo-2'-deoxiguanosina ADH: álcool desidrogenase AKT:
International Journal of Oral Science, Год журнала: 2021, Номер 13(1)
Опубликована: Март 16, 2021
Issues caused by maxillofacial tumours involve not only dealing with but also repairing jaw bone defects. In traditional tumour therapy, the systemic toxicity of chemotherapeutic drugs, invasive surgical resection, intractable recurrence, and metastasis are major threats to patients' lives in clinic. Fortunately, biomaterial-based intervention can improve efficiency treatment decrease possibility recurrence metastasis, suggesting new promising antitumour therapies. addition, tissue defects their negatively affect physiological psychological health patients, investment result a multitude burdens society. Biomaterials options because they have good biocompatibility bioactive properties for stimulation regeneration. More interestingly, an integrated material regimen that combines therapy repair is option. Herein, we summarized biomaterial-mediated treatments analysed biomaterials defect repair. Furthermore, proposed superior design dual-functional simultaneous regeneration provide strategy managing quality life patients future.
Язык: Английский
Процитировано
110
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(5), С. 2561 - 2561
Опубликована: Март 4, 2021
Oral cancers constitute the majority of head and neck tumors, with a relatively high incidence poor survival rate in developing countries. While five-year rates oral cancer patients have increased to 65%, overall for advanced stages has been at 27% past ten years, emphasizing necessity further understanding etiology disease, diagnosis, formulating possible novel treatment regimens. MicroRNAs (miRNAs), family small non-coding RNA, emerged as master modulators gene expression various cellular biological process. Aberrant these dynamic molecules associated many human diseases, including cancers. The deregulated miRNAs shown control oncogenic processes, sustaining proliferative signaling, evading growth suppressors, resisting cell death activating invasion metastasis, inducing angiogenesis. Hence, aberrant cancers, makes them potential candidates investigation functional markers, which will aid differential prognosis, development therapeutic This review presents holistic insight into our role regulating hallmarks tumorigenesis.
Язык: Английский
Процитировано
61
Oncology Reports, Год журнала: 2023, Номер 50(6)
Опубликована: Окт. 20, 2023
Oral squamous cell carcinoma (OSCC) is the most common malignancy of oral cavity and accounts for >90% all cancers. Despite advances in diagnostic procedures therapeutic interventions, overall survival has not improved significantly recent decades, primarily due to late diagnosis, locoregional recurrence treatment resistance. Identifying reliable biomarkers early detection, prognosis evaluation response prediction critical improving clinical outcomes patients with OSCC. In present review, prognostic predictive utility circulating biomarkers, such as tumour cells, serological histological genetic were explored context addition, potential role immune checkpoints OSCC was highlighted rapidly evolving field liquid biopsy its revolutionize examined. The existing evidence these critically evaluated challenges limitations associated their introduction into routine practice addressed. conclusion, review highlights promising current understanding pathogenesis offers avenues patient care through personalized medicine approaches.
Язык: Английский
Процитировано
27
Cancers, Год журнала: 2021, Номер 13(22), С. 5772 - 5772
Опубликована: Ноя. 18, 2021
The association between pretreatment nutritional status and immunotherapy response in patients with advanced head neck cancer is unclear. We retrospectively analyzed a cohort of 99 who underwent treatment anti-PD-1 or anti-CTLA-4 antibodies (or both) for stage IV HNSCC 2014 2020 at the Johns Hopkins Hospital. Patient demographics clinical characteristics were retrieved from electronic medical records. Baseline prognostic index (PNI) scores body mass (BMI) trends calculated. Associations PNI BMI correlated overall survival (OS), progression-free (PFS), response. In univariate analysis, there was significant correlation OS PFS baseline (OS: HR: 0.464; 95% CI: 0.265-0.814; PFS: p = 0.007 0.525; 0.341-0.808; 0.003). Poor also associated greater decrease trend (HR: 0.42; 0.229-0.77; 0.005). multivariate but not significantly log (HR) -0.79, -1.6, -0.03, 0.041; -0.78, -1.4, -0.18, 0.011). conclusion, poor negative post-immunotherapy outcomes.
Язык: Английский
Процитировано
38
Biomedicines, Год журнала: 2021, Номер 9(2), С. 194 - 194
Опубликована: Фев. 16, 2021
Background: The programmed cell death ligand 1/programmed receptor 1 (PD-L1/PD-1) Immune Checkpoint is an important modulator of the immune response. Overexpression and its ligands involved in immunosuppression failure response against tumor cells. PD-1/PD-L1 overexpression oral squamous carcinoma (OSCC) compared to healthy mucosa (NOM) has already been demonstrated. However, little known about expression precancerous lesions like leukoplakia (OLP). aim study was investigate whether increased exists OLP it associated with malignant transformation. Material Methods: PD-1 PD-L1 immunohistologically analyzed separately epithelium (E) subepithelium (S) that had undergone transformation within 5 years (T-OLP), without (N-OLP), corresponding OSCC NOM. Additionally, RT-qPCR analysis for done entire tissues. association between transformation, dysplasia inflammation were examined. Results: Compared N-OLP, there levels protein epithelial subepithelial layers T-OLP (pE = 0.001; pS 0.005). There no significant difference mRNA N-OLP (p 0.128), but fold-change increase these groups (Relative Quantification (RQ) 3.1). In contrast significantly 0.007), not 0.25). Importantly, years. Conclusion: Increased are related may represent a promising prognostic indicator determine risk progression OLP. might establish immunosuppressive microenvironment, which could favor escape thereby contribute Hence, checkpoint inhibitors counteract development serve as efficient therapeutic strategy patients high-risk lesions.
Язык: Английский
Процитировано
33
Cancers, Год журнала: 2022, Номер 14(24), С. 6079 - 6079
Опубликована: Дек. 10, 2022
Head and neck cancer (HNC), also known as the that can affect structures between dura mater pleura, is 6th most common type of cancer. This heterogeneous group malignancies usually treated with a combination surgery radio- chemotherapy, depending on if disease localized or at an advanced stage. However, HNC patients are diagnosed stage, resulting in death half these patients. Thus, prognosis recurrent/metastatic HNC, especially squamous cell carcinoma (HNSCC), notably poorer than HNC. review explores epidemiology etiologic factors histopathology this cancer, diagnosis methods treatment approaches currently available. Moreover, special interest given to novel therapies used treat subtypes worse prognosis, exploring immunotherapies targeted/multi-targeted drugs undergoing clinical trials, well light-based (i.e., photodynamic photothermal therapies).
Язык: Английский
Процитировано
24
Biomedicines, Год журнала: 2023, Номер 11(11), С. 3029 - 3029
Опубликована: Ноя. 11, 2023
The assessment of volatile breath biomarkers has been targeted with a lot interest by the scientific and medical communities during past decades due to their suitability for an accurate, painless, non-invasive, rapid diagnosis health states pathological conditions. This paper reviews most relevant bibliographic sources aiming gather pertinent organic compounds (VOCs) already identified as putative cancer biomarkers. Here, total 265 VOCs respective are addressed regarding scientifically proven diagnose six carcinogenic diseases, namely lung, breast, gastric, colorectal, prostate, squamous cell (oesophageal laryngeal) cancers. In addition, future trends in identification five other forms cancer, such bladder, liver, ovarian, pancreatic, thyroid through perspective equally presented discussed. All results achieved detection, identification, quantification endogenous metabolites produced all kinds normal abnormal processes human body denote promising auspicious this alternative diagnostic tool, whose passes development employment newer more accurate collection analysis techniques, certification utilisation real clinical scenarios.
Язык: Английский
Процитировано
11
The Journal of Liquid Biopsy, Год журнала: 2025, Номер 7, С. 100285 - 100285
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0
Lecture notes in computer science, Год журнала: 2025, Номер unknown, С. 214 - 221
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
International Journal of Computer Assisted Radiology and Surgery, Год журнала: 2021, Номер 16(4), С. 529 - 542
Опубликована: Март 5, 2021
Язык: Английский
Процитировано
26