Rhus coriaria (Sumac) induces autophagic cell death and inhibits mTOR, p38MAPK and STAT3 pathways in 5fluorouracil-resistant colorectal cancer cells DOI Creative Commons
Zohra Nausheen Nizami,

Mazoun Al Azzani,

Soumaya Khaldi

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Introduction Colorectal cancer is a leading cause of related-death worldwide, and resistance to 5-fluorouracil (5FU, key component chemotherapy regimens, major clinical concern. We have previously elucidated the effects Rhus coriaria ethanolic extract (RCE) in triple-negative breast cancer, CRC, pancreatic cells. Here, we explored anticancer RCE parental (HCT-116-WT) 5FU-resistant HCT-116 (HCT-116-5FU-R) CRC Methods MTT assay was used assess cell viability. Muse analyzer viability, cycle distribution, apoptosis. Additionally, colony formation growth assays western blots were performed. In vivo assessed by an ovo chick embryo tumor assay. Results found that inhibited viability capacities HCT-116-WT HCT-116-5FU-R The antiproliferative attributed DNA damage-mediated impairment at S phase, induction Beclin-1-independent autophagy both lines. Mechanistically, inhibition mTOR, STAT3 p38 MAPK pathways implicated latter. induced caspase-7-independent apoptosis However, cells resistant through upregulation survivin, downregulation Bax. Using proteasome inhibitors, clarified pathway contributed RCE-mediated death Lastly, confirmed xenografts model. Discussion Collectively, our findings highlight source phytochemicals can be as agents for CRC.

Язык: Английский

Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances DOI
Dharshini Jagadeesan,

Kathiresan V. Sathasivam,

Neeraj Kumar Fuloria

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 261, С. 155489 - 155489

Опубликована: Июль 27, 2024

Язык: Английский

Процитировано

10
Design and fabrication of a novel platform for detection of 5-fluorouracil as the anti-cancer drug using COFs/MOFs nanocomposite with graphene quantum dotes DOI
Biuck Habibi, Sara Pashazadeh

Microchemical Journal, Год журнала: 2024, Номер unknown, С. 111657 - 111657

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

8
Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer DOI Creative Commons
Chunge Zhong, Shengnan Wang, Wenjie Jiang

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 19, 2025

Язык: Английский

Процитировано

1
Cerium oxide decorated 5-fluorouracil loaded chitosan nanoparticles for treatment of hepatocellular carcinoma DOI
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Myeong‐Hyeon Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 216, С. 52 - 64

Опубликована: Июнь 22, 2022

Язык: Английский

Процитировано

28
Strategies of nanomedicine for targeting the signaling pathways of Colorectal cancer DOI

Mohammad Habeeb,

Huay Woon You, Kiran Balasaheb Aher

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 84, С. 104487 - 104487

Опубликована: Апрель 20, 2023

Язык: Английский

Процитировано

19
Solid lipid-based nanoparticulate system for sustained release and enhanced in-vitro cytotoxic effect of 5-fluorouracil on skin Melanoma and squamous cell carcinoma DOI Creative Commons
Ahsan Ali, Asadullah Madni,

Hassan Shah

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(2), С. e0281004 - e0281004

Опубликована: Фев. 28, 2023

The present study aimed to prepare solid lipid-based nanoparticles (SLNs) using Precirol ® ATO 5 as lipid and Poloxamer 188 Tween 80 surfactant co-surfactant respectively, SLNs-derived gel for sustained delivery, enhanced in-vitro cytotoxicity, cellular uptake of 5-FU permeation across the skin. 5-FU-loaded SLNs were prepared by hot melt encapsulation method converted into SLN-derived a gelling agent (Carbopol 940). had particle size in range 76.82±1.48 327±4.46 nm, zeta potential between -11.3±2.11 -28.4±2.40 mV, entrapment efficiency (%) 63.46±1.13 76.08±2.42. FTIR analysis depicted that there was no chemical interaction formulation components. Differential scanning calorimetric showed thermal stability powdered X-ray diffraction revealed successful incorporation nanoparticles. release biphasic behavior with initial burst followed over 48 hr. greater cytotoxic effect on skin melanoma (B16F10 cells) squamous cell carcinoma (A-431 compared free drug solution after Flow cytometry fluorescence microscopy displayed quantitative qualitative SLNs. acceptable safety biocompatible profile an acute toxicity Wistar rats. Moreover, ex-vivo studies 2.13±0.076 folds flux SLN derived plain gel, retention target 2.54±0.03 gel.

Язык: Английский

Процитировано

16
αvβ3 Integrin and Folate-Targeted pH-Sensitive Liposomes with Dual Ligand Modification for Metastatic Breast Cancer Treatment DOI Creative Commons
Prashant Pandey, Dilip Kumar Arya, Payal Deepak

и другие.

Bioengineering, Год журнала: 2024, Номер 11(8), С. 800 - 800

Опубликована: Авг. 7, 2024

The advent of pH-sensitive liposomes (pHLips) has opened new opportunities for the improved and targeted delivery antitumor drugs as well gene therapeutics. Comprising fusogenic dioleylphosphatidylethanolamine (DOPE) cholesteryl hemisuccinate (CHEMS), these nanosystems harness acidification in tumor microenvironment endosomes to deliver effectively. pH-responsive that are internalized through endocytosis encounter mildly acidic pH thereafter fuse or destabilize endosomal membrane, leading subsequent cargo release into cytoplasm. extracellular matrix also presents a slightly environment can lead enhanced drug targeting capabilities nano-delivery system. Recent studies have shown folic acid (FA) iRGD-coated nanocarriers, including liposomes, preferentially accumulate breast tumors overexpress folate receptors αvβ3 αvβ5 integrins. This study focuses on development characterization 5-Fluorouracil (5-FU)-loaded FA iRGD surface-modified pHLips (FA-iRGD-5-FU-pHLips). novelty this research lies dual mechanism utilizing peptides, combined with properties enhance selective uptake by cancer cells effective environment. prepared were small, an average diameter 152 ± 3.27 nm, uniform, unilamellar, demonstrating efficient 5-FU encapsulation (93.1 2.58%). Despite surface functionalization, maintained their sensitivity neutral zeta potential, which conferred stability reduced aggregation. Effective responsiveness was demonstrated observation at 5.5 compared physiological 7.4. (84.47% versus 46.41% 7.4, respectively, 72 h). formulations exhibited six months stable when subjected simulated biological settings. Blood compatibility cytotoxicity MDA-MB-231 SK-BR3 cell lines revealed liposomal formulation modified free minimal hemolysis. Collectively, findings support potential surface-camouflaged, promising strategy treatment.

Язык: Английский

Процитировано

6
The role of CircRNA/miRNA/mRNA axis in breast cancer drug resistance DOI Creative Commons
Mohammad H. Ghazimoradi, Sadegh Babashah

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Сен. 5, 2022

Multidrug resistance is one of the major obstacles in treatment cancers. This undesirable feature increases mortality rate cancers, including breast cancer. Circular RNA (CircRNA)/microRNA (miRNA)/messenger (mRNA) important axes with roles promotion and heterogeneous pathway includes mRNA oncogenes tumor suppressors, which are controlled by miRNAs CircRNAs. Unfortunately, this network could be easily deregulated, resulting drug development. Therefore, understanding these dysregulations may thus help to identify effective therapeutic targets. On basis, we try review latest findings field, us better comprehend significant axis

Язык: Английский

Процитировано

24
Assessing the effects of the cytostatic drug 5-Fluorouracil alone and in a mixture of emerging contaminants on the mussel Mytilus galloprovincialis DOI
Joanna M. Gonçalves,

Clara Beckmann,

Maria João Bebianno

и другие.

Chemosphere, Год журнала: 2022, Номер 305, С. 135462 - 135462

Опубликована: Июнь 24, 2022

Язык: Английский

Процитировано

22
Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials DOI Open Access
Ignatios Ioakeim‐Skoufa,

Natalia Tobajas-Ramos,

Enrica Menditto

и другие.

Cancers, Год журнала: 2023, Номер 15(11), С. 2972 - 2972

Опубликована: Май 30, 2023

Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages comparison with traditional drug development procedures, reducing time and risk. This systematic review identified the most recent randomized controlled clinical trials that focus on oncology. We found only a few were placebo-controlled or standard-of-care-alone-controlled. Metformin has been studied for potential use various cancer, including prostate, lung, pancreatic Other studies assessed possible antiparasitic agent mebendazole colorectal cancer propranolol multiple myeloma or, when combined etodolac, breast able to identify study known antineoplastics other non-oncological conditions, such as imatinib severe coronavirus disease 2019 protocol aiming assess leuprolide Alzheimer’s disease. Major limitations these small sample size, high heterogeneity participants regarding stage neoplastic disease, lack accounting multimorbidity baseline characteristics. possibilities oncology must be carefully examined well-designed trials, considering factors could influence prognosis.

Язык: Английский

Процитировано

14