Peer Review #3 of "Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma (v0.1)" DOI Creative Commons

Опубликована: Дек. 19, 2022

Background: Ferroptosis is a new type of iron-and reactive oxygen species-dependent cell death, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear renal carcinoma (ccRCC) are limited.The purpose this study was to investigate the potential prognostic value FerLncRNAs and their relationship with immune microenvironment immunotherapy response ccRCC.Methods: RNA sequencing data 526 patients ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database.The TCGA randomly divided (1:1) into training testing cohort.ICGC GEO databases used for validation.Screening performed using Pearson's correlation analysis reported genes.A FerLncRNA signature constructed univariate, LASSO, multivariate Cox regression analyses cohort.Internal external datasets verify FRlncRNA signature.Four major FRlncRNAs verified through vitro experiment.Results: We identified seven (LINC00894, DUXAP8, LINC01426, PVT1, PELATON, LINC02609, MYG1-AS1), established risk nomogram predicting prognosis ccRCC.Four GEPIA K-M Plotter databases, expressions validated by realtime PCR.The can also effectively reflect environment, drug sensitivity ccRCC.These have great significance implementation individualized treatment disease monitoring patients.

Язык: Английский

Ferroptosis and the bidirectional regulatory factor p53 DOI Creative Commons
Ren Xu,

Wanning Wang,

Wenlong Zhang

и другие.

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Июнь 29, 2023

Ferroptosis is a type of regulated cell death characterized by iron-mediated lipid peroxidation, in contrast with apoptosis, autophagy, and necrosis. It can be triggered many pathological processes, including cellular metabolism, tumors, neurodegenerative diseases, cardiovascular ischemia-reperfusion injuries. In recent years, ferroptosis has been discovered to associated p53. P53 tumor suppressor protein multiple powerful functions cycle arrest, senescence, death, repair DNA damage, mitophagy. Emerging evidence shows that plays crucial role suppression as key bidirectional regulator adjusting metabolism iron, lipids, glutathione peroxidase 4, reactive oxygen species, amino acids via canonical pathway. addition, noncanonical pathway p53 regulates years. The specific details require further clarified. These mechanisms provide new ideas for clinical applications, translational studies have performed treat various diseases.

Язык: Английский

Процитировано

69
Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment DOI Creative Commons
Natalie K. Horvat, Sara Chocarro, Oriana Marques

и другие.

ACS Nano, Год журнала: 2024, Номер 18(17), С. 11025 - 11041

Опубликована: Апрель 16, 2024

ALK-positive NSCLC patients demonstrate initial responses to ALK tyrosine kinase inhibitor (TKI) treatments, but eventually develop resistance, causing rapid tumor relapse and poor survival rates. Growing evidence suggests that the combination of drug immune therapies greatly improves patient survival; however, due low immunogenicity tumors, do not respond currently available immunotherapies. Tumor-associated macrophages (TAMs) play a crucial role in facilitating lung cancer growth by suppressing tumoricidal activation absorbing chemotherapeutics. However, they can also be programmed toward pro-inflammatory suppressive phenotype, which represents highly active area therapy development. Iron loading TAMs achieve such reprogramming correlating with an improved prognosis patients. We previously showed superparamagnetic iron oxide nanoparticles containing core-cross-linked polymer micelles (SPION-CCPMs) target stimulate activation. Here, we show SPION-CCPMs secrete reactive nitrogen species cytokines exert activity. further reshape immunosuppressive

Язык: Английский

Процитировано

14
Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

и другие.

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Янв. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Язык: Английский

Процитировано

1
The Regulation of Ferroptosis by Noncoding RNAs DOI Open Access
Xiangnan Zheng, Cen Zhang

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13336 - 13336

Опубликована: Авг. 28, 2023

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and lipid peroxide accumulation, which different from other death forms morphologically, biochemically, immunologically. Ferroptosis metabolism, antioxidant defense systems as well various transcription factors related signal pathways. Emerging evidence has highlighted that associated with many physiological pathological processes, including cancer, neurodegeneration diseases, cardiovascular ischemia/reperfusion injury. Noncoding RNAs are group functional RNA molecules not translated into proteins, can regulate gene expression in manners. An increasing number studies have shown noncoding RNAs, especially miRNAs, lncRNAs, circRNAs, interfere the progression modulating ferroptosis-related genes or proteins directly indirectly. In this review, we summarize basic mechanisms regulations focus on recent mechanism for types ncRNAs to conditions, will deepen our understanding regulation provide new insights employing ferroptosis-associated therapeutic strategies.

Язык: Английский

Процитировано

18
Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study DOI

Mohammad Mahdi Khanifar,

Zahra Zafari, Mohsen Sheykhhasan

и другие.

Pathology - Research and Practice, Год журнала: 2023, Номер 249, С. 154756 - 154756

Опубликована: Авг. 10, 2023

Язык: Английский

Процитировано

15
Epigenetic modulation of ferroptosis in cancer: Identifying epigenetic targets for novel anticancer therapy DOI
Jaewang Lee, Jong‐Lyel Roh

Cellular Oncology, Год журнала: 2023, Номер 46(6), С. 1605 - 1623

Опубликована: Июль 12, 2023

Язык: Английский

Процитировано

13
Ferroptosis and its current progress in gastric cancer DOI Creative Commons

Zhenqi Yue,

Yi‐Wu Yuan,

Qi Zhou

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Фев. 28, 2024

Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as fifth most common malignant tumor worldwide. It characterized by clinical features such tendency for metastasis and an unfavorable prognosis. Ferroptosis, recently identified form of cell death, represents novel mode cellular demise that diverges from traditional concepts necrosis apoptosis. Numerous studies have found ferroptosis plays significant role in proliferation, metastasis, drug resistance, microenvironment regulation GC. This review summarizes mechanism its occurrence development GC cells. provides examples demonstrating how various anti-tumor drugs can induce Additionally, it potential application value future treatment

Язык: Английский

Процитировано

4
Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma DOI Creative Commons
Lincheng Ju,

Yaxing Shi,

Gang Liu

и другие.

PeerJ, Год журнала: 2022, Номер 10, С. e14506 - e14506

Опубликована: Дек. 19, 2022

Background Ferroptosis is a new type of iron- and reactive oxygen species-dependent cell death, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear renal carcinoma (ccRCC) are limited. The purpose this study was to investigate the potential prognostic value FerLncRNAs their relationship with immune microenvironment immunotherapy response ccRCC. Methods RNA sequencing data 526 patients ccRCC were downloaded from Cancer Genome Atlas (TCGA) database. TCGA randomly divided (1:1) into training testing cohort. ICGC GEO databases used for validation. Screening performed using Pearson’s correlation analysis reported genes. A FerLncRNA signature constructed univariate, LASSO, multivariate Cox regression analyses Internal external datasets verify FRlncRNA signature. Four major FRlncRNAs verified through vitro experiment. Results We identified seven (LINC00894, DUXAP8, LINC01426, PVT1, PELATON, LINC02609, MYG1-AS1), established risk nomogram predicting prognosis GEPIA K-M Plotter databases, expressions validated by realtime PCR. can also effectively reflect environment, drug sensitivity These have great significance implementation individualized treatment disease monitoring patients.

Язык: Английский

Процитировано

16
Ferroptosis: opening up potential targets for gastric cancer treatment DOI
Yuwei Li,

Jiangrong Liu,

Shihua Wu

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2023, Номер 479(11), С. 2863 - 2874

Опубликована: Дек. 11, 2023

Язык: Английский

Процитировано

9
Long Non-Coding RNAs in Malignant Human Brain Tumors: Driving Forces Behind Progression and Therapy DOI Open Access

Dakun Pei,

Dandan Zhang, Yan Guo

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 694 - 694

Опубликована: Янв. 15, 2025

Long non-coding RNAs (lncRNAs) play a pivotal role in regulating gene expression and are critically involved the progression of malignant brain tumors, including glioblastoma, medulloblastoma, meningioma. These lncRNAs interact with microRNAs (miRNAs), proteins, DNA, influencing key processes such as cell proliferation, migration, invasion. This review highlights multifaceted impact lncRNA dysregulation on tumor underscores their potential therapeutic targets to enhance efficacy chemotherapy, radiotherapy, immunotherapy. The insights provided offer new directions for advancing basic research clinical applications tumors.

Язык: Английский

Процитировано

0