Osteosarcoma
(OS)
is
a
highly
prevalent
bone
malignancy
among
adolescents,
accounting
for
40%
of
all
primary
malignant
tumors.
Neoadjuvant
chemotherapy
combined
with
limb-preserving
surgery
has
effectively
reduced
patient
disability
and
mortality,
but
pulmonary
metastases
OS
cells'
resistance
to
chemotherapeutic
agents
are
pressing
challenges
in
the
clinical
management
OS.
There
been
an
urgent
need
identify
new
biomarkers
develop
specific
targeted
therapies.
Recently,
continued
advancements
genomic
analysis
have
contributed
identification
clinically
significant
molecular
diagnosing
OS,
acting
as
therapeutic
targets,
predicting
prognosis.
Additionally,
contemporary
classifications
revealed
that
signaling
pathways,
including
Wnt/β-catenin,
PI3K/AKT/mTOR,
JAK/STAT3,
Hippo,
Notch,
PD-1/PD-L1,
MAPK,
NF-κB,
integral
role
onset,
progression,
metastasis,
treatment
response.
These
biological
markers
created
avenues
more
accurate
diagnosis
relevant
treatment.
We
herein
present
review
recent
findings
modulatory
pathways
possible
targets
This
also
discusses
current
approaches,
pathway-based
therapies
developed
over
past
decade.
covers
involved
curative
effects
traditional
Chinese
medicines
context
expression
regulation
genes
proteins
through
inhibit
cell
growth.
expected
provide
directions
integrating
genomic,
molecular,
profiles
enhance
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Сен. 22, 2023
Cancer
is
a
borderless
global
health
challenge
that
continues
to
threaten
human
health.
Studies
have
found
oxidative
stress
(OS)
often
associated
with
the
etiology
of
many
diseases,
especially
aging
process
and
cancer.
Involved
in
OS
reaction
as
key
transcription
factor,
Nrf2
pivotal
regulator
cellular
redox
state
detoxification.
can
prevent
damage
by
regulating
gene
expression
antioxidant
response
elements
(ARE)
promote
process.
generated
an
imbalance
promotes
accumulation
mutations
genome
instability,
thus
establishment
development
different
cancers.
activation
regulates
plethora
processes
inducing
proliferation,
differentiation
death,
strongly
OS-mediated
What’s
more,
also
involved
anti-inflammatory
effects
metabolic
disorders,
neurodegenerative
multidrug
resistance.
highly
expressed
multiple
body
parts
digestive
system,
respiratory
reproductive
system
nervous
system.
In
oncology
research,
has
emerged
promising
therapeutic
target.
Therefore,
certain
natural
compounds
drugs
exert
anti-cancer
through
signaling
pathway,
blocking
pathway
reduce
some
types
tumor
recurrence
rates
increase
sensitivity
chemotherapy.
However,
Nrf2’s
dual
role
controversial
impact
cancer
are
inevitable
consideration
factors
when
treating
this
review,
we
summarized
current
biological
characteristics
its
mechanism
cells,
discussed
Keap1/Nrf2/ARE
downstream
genes,
elaborated
related
pathways
such
AMPK/mTOR
NF-κB.
Besides,
main
target
strategies
using
inhibitors
or
activators,
well
possible
positive
negative
were
reviewed.
It
be
concluded
serves
important
factor
formation
development,
provides
basis
for
targeted
therapy
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(9)
Опубликована: Авг. 7, 2023
With
the
increasing
prevalence
of
cancer
and
toxic
side
effects
synthetic
drugs,
natural
products
are
being
developed
as
promising
therapeutic
approaches.
Gracillin
is
a
naturally
occurring
triterpenoid
steroidal
saponin
with
several
activities.
It
obtained
major
compound
from
different
Dioscorea
species.
This
review
was
designated
to
summarize
research
progress
on
anti-cancer
activities
gracillin
focusing
underlying
cellular
molecular
mechanisms,
well
its
pharmacokinetic
features.
The
data
were
collected
(up
date
May
1,
2023)
various
reliable
authentic
literatures
comprising
PubMed,
Springer
Link,
Scopus,
Wiley
Online,
Web
Science,
ScienceDirect,
Google
Scholar.
findings
demonstrated
that
displays
anticancer
through
including
anti-inflammatory
effects,
apoptotic
cell
death,
induction
oxidative
stress,
cytotoxicity,
genotoxicity,
cycle
arrest,
anti-proliferative
effect,
autophagy,
inhibition
glycolysis,
blocking
migration.
Additionally,
this
highlighted
features
gracillin,
indicating
lower
oral
bioavailability.
As
conclusion,
it
can
be
proposed
could
serve
hopeful
chemotherapeutic
agent.
However,
further
extensive
clinical
recommended
establish
safety,
efficacy,
potential
in
treatment.
Journal of Biological Chemistry,
Год журнала:
2023,
Номер
299(11), С. 105344 - 105344
Опубликована: Окт. 12, 2023
Recent
advances
in
the
understanding
of
molecular
mechanisms
underlying
cancer
progression
have
led
to
development
novel
therapeutic
targeting
strategies.
Aberrant
glycosylation
patterns
and
their
implication
gained
increasing
attention
as
potential
targets
due
critical
role
regulating
tumor-specific
pathways
that
contribute
cell
survival,
proliferation,
progression.
A
special
type
has
been
gaining
momentum
research
is
modification
nuclear,
cytoplasmic,
mitochondrial
proteins,
termed
O-GlcNAcylation.
This
protein
catalyzed
by
an
enzyme
called
O-GlcNAc
transferase
(OGT),
which
uses
final
product
Hexosamine
Biosynthetic
Pathway
(HBP)
connect
altered
nutrient
availability
changes
cellular
signaling
multiple
aspects
tumor
Both
its
OGT
are
highly
elevated
fulfill
crucial
many
hallmarks
cancer.
In
this
review,
we
present
discuss
latest
findings
elucidating
involvement
Osteosarcoma
(OS)
is
a
highly
prevalent
bone
malignancy
among
adolescents,
accounting
for
40%
of
all
primary
malignant
tumors.
Neoadjuvant
chemotherapy
combined
with
limb-preserving
surgery
has
effectively
reduced
patient
disability
and
mortality,
but
pulmonary
metastases
OS
cells'
resistance
to
chemotherapeutic
agents
are
pressing
challenges
in
the
clinical
management
OS.
There
been
an
urgent
need
identify
new
biomarkers
develop
specific
targeted
therapies.
Recently,
continued
advancements
genomic
analysis
have
contributed
identification
clinically
significant
molecular
diagnosing
OS,
acting
as
therapeutic
targets,
predicting
prognosis.
Additionally,
contemporary
classifications
revealed
that
signaling
pathways,
including
Wnt/β-catenin,
PI3K/AKT/mTOR,
JAK/STAT3,
Hippo,
Notch,
PD-1/PD-L1,
MAPK,
NF-κB,
integral
role
onset,
progression,
metastasis,
treatment
response.
These
biological
markers
created
avenues
more
accurate
diagnosis
relevant
treatment.
We
herein
present
review
recent
findings
modulatory
pathways
possible
targets
This
also
discusses
current
approaches,
pathway-based
therapies
developed
over
past
decade.
covers
involved
curative
effects
traditional
Chinese
medicines
context
expression
regulation
genes
proteins
through
inhibit
cell
growth.
expected
provide
directions
integrating
genomic,
molecular,
profiles
enhance
