Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 267 - 288
Опубликована: Янв. 1, 2023
Язык: Английский
Discover Oncology, Год журнала: 2024, Номер 15(1)
Опубликована: Апрель 1, 2024
Abstract Breast cancer is a significant and deadly threat to women globally. Moreover, metastasis complicated process involving multiple biological stages, which considered substantial cause of death, where cells spread from the original tumor other organs in body—representing primary mortality factor. Circulating (CTCs) are detached or metastatic enter bloodstream, allowing them establish new sites. CTCs can travel alone groups called CTC clusters. Studies have shown that clusters more potential for poorer prognosis than individual breast patients. However, our understanding clusters' formation, structure, function, detection still limited. This review summarizes current knowledge properties, isolation, prognostic significance cancer. It also highlights challenges future directions research clinical application
Язык: Английский
Процитировано
15
Hematology/Oncology Clinics of North America, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
EMBO Molecular Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Abstract The gut microbiome, or the community of microorganisms residing in gastrointestinal tract, has emerged as an important factor breast cancer etiology and treatment. Specifically, impact bacterial populations on therapeutic outcomes is emerging area research. microbiota’s role modifying pharmacokinetics chemotherapy endocrine-targeting therapies can alter drug efficacy toxicity profiles. In addition, microbiome’s capacity to regulate systemic inflammation immune responses may influence effectiveness both conventional immunotherapeutic strategies for treatment cancer. Overall, while bidirectional interactions between microbiome are still being studied, its increasingly recognized. Future research provide more definitive insights help develop personalized harness improve outcomes.
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2023, Номер 15(3), С. 594 - 594
Опубликована: Янв. 18, 2023
In this first analysis, samples from 23 BC survivors (group 1) and 291 healthy female controls 2) were characterised through the V3 V4 regions that encode “16S rRNA” gene of each bacteria. The sequenced by next-generation sequencing (NGS), taxonomy was identified resorting to Kraken2 improved with Bracken, using a curated database called ‘GutHealth_DB’. α β-diversity analyses used determine richness evenness gut microbiota. A non-parametric Mann-Whitney U test applied assess differential abundance between both groups. Firmicutes/Bacteroidetes (F/B) ratio calculated Kruskal-Wallis chi-squared test. α-diversity significantly higher in group 1 (p = 0.28 × 10−12 for Chao index p 1.64 ACE index). Shannon index, marker evenness, not statistically different two groups 0.72). microbiota composition groups: null hypothesis rejected PERMANOVA 9.99 10−5) Anosim 0.04) β-dispersion 0.158), Unifrac weighted distance. relative 14 phyla, 29 classes, 25 orders, 64 families, 116 genera, 74 species differed F/B lower than 2, < 0.001. Our study allowed us observe significant taxonomic disparities testing differences controls. Additional studies are needed clarify involved mechanisms explore relationship survivorship.
Язык: Английский
Процитировано
15
Frontiers in Pharmacology, Год журнала: 2022, Номер 13
Опубликована: Окт. 25, 2022
Salvia miltiorrhiza Bunge (Lamiaceae) is a perennial herb widely found in China since ancient times with high economic and medicinal value. Salvianolic acid B (Sal-B) an important natural product derived from this review summarizes the anticancer activity of Sal-B. Sal-B inhibits tumor growth metastasis by targeting multiple cell signaling pathways. This aims to experimental studies describe possible mechanisms confirm its potential as therapeutic drug.
Язык: Английский
Процитировано
20
Clinical & Translational Oncology, Год журнала: 2024, Номер unknown
Опубликована: Июнь 18, 2024
Abstract Breast cancer (BC) is one of the most diagnosed cancers in women. Based on histological characteristics, they are classified as non-invasive, or situ (tumors located within milk ducts lobules) and invasive. BC may develop from carcinomas over time. Determining prognosis predicting response to treatment essential tools manage this disease reduce its incidence mortality, well promote personalized therapy for patients. However, half cases not associated with known risk factors. In addition, some patients resistance relapse. Therefore, it necessary identify new biomarkers strategies that improve existing therapies. regard, role microbiome being researched could play a carcinogenesis efficacy This review aims describe specific patterns BC. For this, literature search was carried out PubMed database using MeSH terms “Breast Neoplasms” “Gastrointestinal Microbiome”, including 29 publications. Most studies have focused characterizing gut breast tissue Likewise, animal models vitro investigated impact microbiota (GM) treatments effects tumor cells were included. results included articles, be an imbalance GM. varied depending molecular type, stage grade cancer, menopause, menarche, body mass index, physical activity. microbial profile identified biomarker. On other hand, suggest GM influence microorganisms bacterial metabolites therapies development.
Язык: Английский
Процитировано
5
Oncology Letters, Год журнала: 2025, Номер 29(4), С. 1 - 9
Опубликована: Март 4, 2025
Evidence suggests that various gut metabolites significantly impact breast cancer (BC) and its treatment. However, the underlying mechanisms remain poorly understood require further investigation. In present study, current literature was reviewed to evaluate roles of microbial in development BC response Microbial metabolites, including secondary bile acids, short‑chain fatty amino acid lipopolysaccharide, nisin pyocyanin, serve crucial microenvironment. promote invasion, metastasis recurrence by facilitating cellular movement, epithelial‑mesenchymal transition, stem cell function diapedesis. Furthermore, certain such as trimethylamine N‑oxide L‑norvaline, can alter pharmacokinetics chemotherapeutic drugs. The review highlights possible involvement bacteriocins carcinogenesis, metastasis. These could provide new insights for treatment strategies are considered potential therapeutic targets.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Май 27, 2025
Breast cancer is the most prevalent malignancy among women worldwide and a major contributor to cancer-related mortality. The tumor microenvironment (TME), composed of cells, immune infiltrates, fibroblasts, vascular components, critically involved in initiation, metastatic progression, therapeutic response. In recent years, therapies targeting TME have undergone rapid advancements, with objective enhancing antitumor immunity. Concurrently, mounting evidence underscores pivotal role gut microbiota its metabolites modulating host immunity, influencing metabolic homeostasis, inflammation, equilibrium. composition diversity microbiome influence breast progression patients’ responses immunotherapy. Therefore, promising strategy enhance clinical outcomes TME-targeted immunotherapies. this review, we discuss derived on immunotherapy prognosis explore potential strategies optimize through modulation.
Язык: Английский
Процитировано
0
Cancer Reports, Год журнала: 2023, Номер 6(11)
Опубликована: Авг. 4, 2023
Abstract Background The second most frequent cancer in the world and common malignancy women is breast cancer. Breast a significant health concern India with high mortality‐to‐incidence ratio presentation at younger age. Recent Findings studies have identified gut microbiota as factor that can an influence on development, treatment, prognosis of This review article aims to describe microbial dysbiosis occurrence possible interactions between oncobiome specific molecular subtypes. further also discusses role epigenetics diet/nutrition regulation microbiome its association prevention, therapy, recurrence. Additionally, recent technological advances research, including next‐generation sequencing (NGS) technologies, genome sequencing, single‐cell metabolomics along artificial intelligence (AI) been reviewed. attempt present comprehensive status key biomarker. Conclusion We believe correlating carcinogenesis important it provide insights into mechanisms by which development progression, leading potential use tool for prognostication personalized therapy.
Язык: Английский
Процитировано
8
Advances in medical technologies and clinical practice book series, Год журнала: 2024, Номер unknown, С. 212 - 233
Опубликована: Апрель 26, 2024
The objective of this review is to systematically examine several papers that observe the complex relationships between pharmaceutical treatments and human microbiota, highlighting how these relations may affect course treatment. To assure a thorough analysis data current literature, was voted for make use databases. PubMed, Open University, Academia Sinica, Southern Methodist Yale Google Scholar were central This study analyzes 1300 articles from first search. After eradicating duplicate (348), 952 endured abstract screening. abstracts observed, 212 publications excluded. full-text screening process, 641 740 remaining estimated ineligible conferring predetermined inclusion criteria. 99 fulfilled all requirements incorporated into final analysis. examination published 2010 2023 has provided important new information about interplay among microbiota effectiveness. Even with countless advancements in microbiome research, there are still numerous unanswered questions. systematic covering wide range medical specialties significant implications practical applications as well guidelines future study. understand dynamic nature interactions, longitudinal studies monitoring variations composition medication responses over time important.
Язык: Английский
Процитировано
2