Visual Analysis of Traditional Chinese Medicine Used in Treating Lung Cancer Based on the Web of Science Database DOI Creative Commons
F. Xiao‐Feng Qin,

Cong-En Zhang,

Shanshan Gao

и другие.

World Journal of Traditional Chinese Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Abstract Objective: We undertook a knowledge map-based visual analysis of the literature concerning use Traditional Chinese Medicine (TCM) for treating lung cancer. By examining publications over past three decades, we aimed to elucidate current status research, identify key areas focus, and anticipate future trends in this field, thereby providing valuable insights scientific clinical investigations. Materials Methods: Using CiteSpace VOSviewer software, scientometric was conducted on from Web Science Core Collection Database spanning 1994–2023, focusing TCM context cancer treatment. Results: In total, 857 were included. The volume 1994 2023 followed an exponential function y = 0.8837e 0.2335x , with average annual publication rate 28.6 articles, indicating growing interest field. China emerged as most prolific contributor, accounting approximately 92.88% total literature. Shanghai University leading institution, contributing 8.63% publications, Ling Xu being author, representing 1.98%. There are notable collaborative relationships among different countries, institutions, authors that need be maintained nurtured. journal highest Evidence-based Complementary Alternative which accounted 6.18% cited Journal Ethnopharmacology whereas CA-A Cancer Clinicians had significant impact (Impact Factor 254.700). “Global statistics 2018: GLOBOCAN estimates incidence mortality worldwide 36 cancers 185 countries,” paper centrality “Pilot study huachansu patients hepatocellular carcinoma, nonsmall-cell cancer, or pancreatic cancer.” Key research hotspots mainly focus quality life treated TCM, NSCLC, apoptosis, metastasis, exploration anti-cancer mechanisms TCM. Research has focused exploring potential treatment through approaches such network pharmacology molecular docking. Conclusions: This provides in-depth comprehensive perspective identified status, hotspots, emerging offering invaluable information researchers.

Язык: Английский

Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment DOI Open Access
Tianqing Zhang,

Wenxu Deng,

Ying Deng

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 114706 - 114706

Опубликована: Июль 1, 2023

Acute myocardial infarction remains the leading cause of death in humans. Timely restoration blood perfusion to ischemic myocardium most effective strategy treatment acute infarction, which can significantly reduce morbidity and mortality. However, after flow reperfusion, injury will aggravate induce apoptosis cardiomyocytes, a process called ischemia-reperfusion injury. Studies have shown that loss cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflammation mitochondrial dysfunction, etc., are involved In recent years, with in-depth research on pathology injury, people gradually realized there is new form cell pathological namely ferroptosis. A number studies found tissue patients changes closely related ferroptosis, such as metabolism disorder, reactive oxygen species free radicals. Natural plant products resveratrol, baicalin, cyanidin-3-O-glucoside, naringenin, astragaloside IV also exert therapeutic effects correcting imbalance these ferroptosis-related factors expression levels. Combining our previous studies, this review summarizes regulatory mechanism natural intervening ferroptosis order provide reference information for development targeted inhibitor drugs cardiovascular diseases.

Язык: Английский

Процитировано

34
Advancements in research on the immune-inflammatory mechanisms mediated by NLRP3 inflammasome in ischemic stroke and the regulatory role of natural plant products DOI Creative Commons
Kailin Yang,

Liuting Zeng,

Qi He

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 27, 2024

Ischemic stroke (IS) is a major cause of mortality and disability among adults. Recanalization blood vessels to facilitate timely reperfusion the primary clinical approach; however, itself may trigger cerebral ischemia-reperfusion injury. Emerging evidence strongly implicates NLRP3 inflammasome as potential therapeutic target, playing key role in ischemia The aberrant expression function inflammasome-mediated inflammation have garnered considerable attention recent research focus. Accordingly, this review provides comprehensive summary signaling pathways, pathological mechanisms, intricate interactions involving inflammasomes Moreover, notable progress has been made investigating impact natural plant products (e.g., Proanthocyanidins, methylliensinine, salidroside, α-asarone, acacia, curcumin, morin, ginsenoside Rd, paeoniflorin, breviscapine, sulforaphane, etc.) on regulating by modulating mitigating release inflammatory cytokines. These findings aim present novel insights that could contribute prevention treatment

Язык: Английский

Процитировано

7
Treatment of diabetic retinopathy with herbs for tonifying kidney and activating blood circulation: A review of pharmacological studies DOI
Huan Liang, Ren Yuan,

Yuxia Huang

и другие.

Journal of Ethnopharmacology, Год журнала: 2024, Номер 328, С. 118078 - 118078

Опубликована: Март 20, 2024

Язык: Английский

Процитировано

4
Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach DOI
Mohd Imran, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

и другие.

Biogerontology, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
Tanshinone IIA Reverses Osteogenic Differentiation of Bone Marrow Mesenchymal Stromal Cells Impaired by Glucocorticoids via the ERK1/2‐CREB Signaling Pathway DOI Open Access
Xiaodong Li, Xinyue Yang, Zelin Liu

и другие.

Chemical Biology & Drug Design, Год журнала: 2025, Номер 105(3)

Опубликована: Март 1, 2025

Glucocorticoids-induced osteoporosis poses a critical health issue due to its detrimental impact on bone marrow mesenchymal stem cells (BMSCs); Tanshinone IIA (TSA) emerges as promising therapeutic intervention, demonstrating capacity reverse osteogenic differentiation impairment. The aim is determine whether TSA enhances the of BMSCs damaged by dexamethasone (DEX) through ERK1/2 -CREB signaling pathway. were treated with varying concentrations DEX (0.1-30 μM) and (0.04-5 for 18 or 36 h. Cell viability was assessed using MTT assay. Osteogenic evaluated Alizarin Red S staining quantified qRT-PCR markers such Runx2 ALP. Apoptosis measured Annexin V-FITC/PI TUNEL/DAPI co-staining. ERK1/2-CREB pathway examined Western blot immunofluorescence. at 5 μM significantly bolstered differentiation, reversing deleterious effects 30 DEX. pre-treatment decreased apoptosis ROS levels, importantly, it enhanced pathway, evidenced increased phosphorylation CREB. inhibitor PD98059 siCREB abrogated TSA's protective effects, highlighting pathway's significance. These findings indicate that TSA, axis, provides strategy against DEX-induced impairment in BMSCs. modulation reverses inhibition BMSCs, suggesting efficacy glucocorticoid-induced disorders.

Язык: Английский

Процитировано

0
Investigating the Therapeutic Potential of Salvianolic Acid B in Ischemic Wound Healing: In Vivo and In Vitro Study DOI

Yi-Tung Tsai,

Jiaming Sun, Yuxin Liu

и другие.

Aesthetic Plastic Surgery, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Salvianolic acid B alleviated myocardial ischemia-reperfusion injury via modulating SIRT3-mediated crosstalk between mitochondrial ROS and NLRP3 DOI
Xiao-Hong Wei, Jie Chen,

Xue-Fen Wu

и другие.

Phytomedicine, Год журнала: 2024, Номер 136, С. 156260 - 156260

Опубликована: Ноя. 14, 2024

Язык: Английский

Процитировано

3
Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure DOI Creative Commons
Tianqing Zhang,

Li Luo,

Qi He

и другие.

European journal of medical research, Год журнала: 2024, Номер 29(1)

Опубликована: Апрель 24, 2024

Abstract The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as cofactor for important proteins such hemoglobin, myoglobin, oxidative respiratory chain, DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF associated with iron dysmetabolism, deficiencies overload can both lead to development various myocarditis diseases, which ultimately progress HF. toxicity may be key targets diagnosis, treatment, prevention Some chelators (such desferrioxamine), antioxidants ascorbate), Fer-1, molecules regulate levels lactoferrin) been effective treating protecting myocardium studies. Additionally, certain natural compounds significant by mediating imbalance iron-related signaling pathways expression levels. Therefore, this review not only summarizes basic processes body mechanisms they HF, aim providing new clues considerations treatment but also on chemical components involve ferroptosis its pathology, well naturally occurring products reference information inhibitors future.

Язык: Английский

Процитировано

2
Salvianolic acid B inhibits the growth and metastasis of A549 lung cancer cells through the NDRG2/PTEN pathway by inducing oxidative stress DOI

Ye Yang,

Lei Huang, Jie Gao

и другие.

Medical Oncology, Год журнала: 2024, Номер 41(7)

Опубликована: Июнь 7, 2024

Язык: Английский

Процитировано

2
Role of salvianolic acid B in the treatment of acute ischemic stroke: a systematic review and meta-analysis of animal models DOI Creative Commons

Jiashan Wang,

Pingping Su,

Chenyu Wan

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 24, 2024

Background Salvianolic acid B (Sal B) is potentially the most valuable water-soluble active component in Salvia miltiorrhiza. Its chemical formula contains multiple phenolic hydroxyl groups, so it has a strong antioxidant capacity. Objective We aim to investigate efficacy and potential mechanism of Sal treatment acute ischemic stroke injury. Materials methods CNKI, VIP, WanFang, SinoMed, PubMed Web Science were searched for all literature related before August 2024. The methodological quality was assessed using an inspection scale combining CAMARADES checklist new STAIR criteria. Data analyzed RevMan5.4 software. Results A total 14 articles included. could effectively reduce infarct size, neurological deficit score, brain edema index, water content cerebral animals. not only increase superoxide dismutase (SOD) decrease malondialdehyde (MDA) achieve anti-oxidative stress, but also level interleukin-1β (IL-1β) protein anti-inflammatory response, number TUNEL cells reflect its anti-apoptosis effect. In addition, can improve energy metabolism by increasing charge (EC) phosphocreatine (PCr), maintaining ion balance via Na + /K ATPase activity, resulting neuroprotective effects against Conclusion This study showed that significantly protect injury, mainly through anti-apoptosis, improving metabolism, stabilizing balance.

Язык: Английский

Процитировано

2