Non-coding RNA Research,
Год журнала:
2024,
Номер
9(4), С. 1178 - 1189
Опубликована: Май 21, 2024
As
the
deadliest
type
of
primary
brain
tumor,
gliomas
represent
a
significant
worldwide
health
concern.
Circular
RNA
(circRNA),
unique
non-coding
molecule,
seems
to
be
one
most
alluring
target
molecules
involved
in
pathophysiology
many
kinds
cancers.
CircRNAs
have
been
identified
as
prospective
targets
and
biomarkers
for
diagnosis
treatment
numerous
disorders,
particularly
malignancies.
Recent
research
has
established
clinical
link
between
temozolomide
(TMZ)
resistance
certain
circRNA
dysregulations
glioma
tumors.
may
play
therapeutic
role
controlling
or
overcoming
TMZ
provide
guidance
novel
kind
individualized
therapy.
To
address
biological
characteristics
circRNAs
their
potential
induce
TMZ,
this
review
highlighted
summarized
possible
roles
that
molecular
pathways
drug
resistance,
including
Ras/Raf/ERK
PI3K/Akt
signaling
pathway
metabolic
processes
gliomas.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Март 8, 2024
Cancer
stands
as
a
prominent
global
cause
of
death.
One
the
key
reasons
why
clinical
tumor
chemotherapy
fails
is
multidrug
resistance
(MDR).
In
recent
decades,
accumulated
studies
have
shown
how
Natural
Product-Derived
Compounds
can
reverse
MDR.
Discovering
novel
potential
modulators
to
reduce
MDR
by
has
become
popular
research
area
across
globe.
Numerous
mainly
focus
on
natural
products
including
flavonoids,
alkaloids,
terpenoids,
polyphenols
and
coumarins
for
their
modulatory
activity.
regulating
signaling
pathways
or
relevant
expressed
protein
gene.
Here
we
perform
deep
review
previous
achievements,
advances
in
development
treatment
This
aims
provide
some
insights
study
products.
Pharmacological Research,
Год журнала:
2024,
Номер
204, С. 107206 - 107206
Опубликована: Май 9, 2024
Chemoresistance
is
a
major
therapeutic
challenge
in
advanced
gastric
cancer
(GC).
N6-methyladenosine
(m6A)
RNA
modification
has
been
shown
to
play
fundamental
roles
progression.
However,
the
underlying
mechanisms
by
which
m6A
of
circRNAs
contributes
GC
and
chemoresistance
remain
unknown.
We
found
that
hsa_circ_0030632
(circUGGT2)
was
predominant
target
METTL14,
METTL14
knockdown
(KD)
reduced
circUGGT2
levels
but
increased
its
mRNA
levels.
The
expression
markedly
cisplatin
(DDP)-resistant
cells.
CircUGGT2
KD
impaired
cell
growth,
metastasis
DDP-resistance
vitro
vivo,
overexpression
prompted
these
effects.
Furthermore,
validated
sponge
miR-186-3p
upregulate
MAP3K9
could
abolish
METTL14-caused
upregulation
downregulation
negatively
correlated
with
harbored
poor
prognosis
patients
GC.
Our
findings
unveil
METTL14-dependent
inhibits
progression
DDP
resistance
regulating
miR-186-3p/MAP3K9
axis.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
171, С. 116165 - 116165
Опубликована: Янв. 18, 2024
Cancer
development
is
a
complex
process
that
primarily
results
from
the
combination
of
genetic
alterations
and
dysregulation
major
signalling
pathways
due
to
interference
with
epigenetic
machinery.
As
regulators,
miRNAs
are
central
players
in
control
many
key
tumour
factors.
These
have
been
classified
as
oncogenic
(oncomiRs)
when
they
target
suppressor
genes
(TS
miRNAs)
inhibit
oncogene
protein
expression.
Most
mechanisms
modulate
oncomiR
expression
linked
transcriptional
or
posttranscriptional
regulation.
However,
non-transcriptional
processes,
such
gene
amplification,
described
alternative
processes
responsible
for
increasing
The
current
review
summarises
different
controlling
upregulation
cancer
cells
microenvironment
(TME).
Detailed
knowledge
mechanism
underlying
regulation
may
pave
way
understanding
critical
role
oncomiRs
progression.
Cancer Cell International,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 5, 2024
Abstract
Chemotherapy
is
currently
one
of
the
most
effective
methods
in
clinical
cancer
treatment.
However,
chemotherapy
resistance
an
important
reason
for
poor
efficacy
and
prognosis,
which
has
become
urgent
problem
to
be
solved
field
chemotherapy.
Therefore,
it
very
deeply
study
analyze
mechanism
its
regulatory
factors.
Long
non-coding
RNA
nuclear
paraspeckle
assembly
transcript
1
(LncRNA
NEAT1)
been
shown
closely
associated
with
cancer.
NEAT1
induces
cell
chemotherapeutic
drugs
by
regulating
apoptosis,
cycle,
drug
transport
metabolism,
DNA
damage
repair,
EMT,
autophagy,
stem
characteristics,
metabolic
reprogramming.
This
indicates
that
may
target
overcome
expected
a
potential
biomarker
predict
effect
article
summarizes
expression
characteristics
different
cancers,
discusses
role
related
molecular
mechanisms,
aiming
clarify
as
new
feasibility
sensitizers,
view
providing
therapeutic
direction
overcoming
dilemma
future.
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 12, 2024
Programmed
cell
death
(PCD)
is
an
evolutionarily
conserved
mechanism
of
suicide
that
controlled
by
various
signaling
pathways.
PCD
plays
important
role
in
a
multitude
biological
processes,
such
as
turnover,
development,
tissue
homeostasis
and
immunity.
Some
forms
PCD,
including
apoptosis,
autophagy-dependent
death,
pyroptosis,
ferroptosis
necroptosis,
contribute
to
carcinogenesis
cancer
thus
have
attracted
increasing
attention
the
field
oncology.
Recently,
research-based
evidence
has
demonstrated
acts
critical
modulator
tumor
can
affect
function
innate
adaptive
immune
cells,
which
leads
distinct
immunological
consequences,
priming
tumor-specific
T
immunosuppression
evasion.
Targeting
alone
or
combination
with
conventional
immunotherapy
may
provide
new
options
enhance
clinical
efficacy
anticancer
therapeutics.
In
this
review,
we
introduce
characteristics
mechanisms
ubiquitous
pathways
(e.g.,
pyroptosis
ferroptosis)
explore
complex
interaction
between
these
immunity
based
on
currently
available
evidence.
We
also
discuss
therapeutic
potential
PCD-based
approaches
outlining
trials
targeting
treatment.
Elucidating
immune-related
effects
pathogenesis
will
likely
improved
understanding
oncoimmunology
allow
be
exploited
for
Epigenetics & Chromatin,
Год журнала:
2025,
Номер
18(1)
Опубликована: Янв. 15, 2025
Colorectal
cancer
(CRC)
remains
one
of
the
most
common
causes
cancer-related
mortality
worldwide.
Its
progression
is
influenced
by
complex
interactions
involving
genetic,
epigenetic,
and
environmental
factors.
Non-coding
RNAs
(ncRNAs),
including
microRNAs
(miRNAs),
long
non-coding
(lncRNAs),
circular
(circRNAs),
have
been
identified
as
key
regulators
gene
expression,
affecting
diverse
biological
processes,
notably
programmed
cell
death
(PCD).
This
review
aims
to
explore
relationship
between
ncRNAs
PCD
in
CRC,
focusing
on
how
influence
survival,
proliferation,
treatment
resistance.
A
comprehensive
literature
analysis
was
conducted
examine
recent
findings
role
modulating
various
mechanisms,
apoptosis,
autophagy,
necroptosis,
pyroptosis,
their
impact
CRC
development
therapeutic
response.
were
found
significantly
regulate
pathways,
impacting
tumor
growth,
metastasis,
sensitivity
CRC.
Their
these
pathways
highlights
potential
biomarkers
for
early
detection
targets
innovative
interventions.
Understanding
involvement
regulation
offers
new
insights
into
biology.
The
targeted
modulation
ncRNA-PCD
presents
promising
avenues
personalized
treatment,
which
may
improve
patient
outcomes
enhancing
effectiveness
reducing
Frontiers in Molecular Neuroscience,
Год журнала:
2022,
Номер
15
Опубликована: Ноя. 9, 2022
Central
nervous
system
(CNS)
disease
is
a
general
term
for
series
of
complex
and
diverse
diseases,
including
Alzheimer’s
(AD),
Parkinson’s
(PD),
multiple
sclerosis
(MS),
CNS
tumors,
stroke,
epilepsy,
amyotrophic
lateral
(ALS).
Interneuron
neuron-glia
cells
communicate
with
each
other
through
their
homeostatic
microenvironment.
Exosomes
in
the
microenvironment
have
crucial
impacts
on
interneuron
by
transferring
contents,
such
as
proteins,
lipids,
ncRNAs,
constituting
novel
form
cell-to-cell
interaction
communication.
Exosomal
noncoding
RNAs
(ncRNAs),
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs),
PIWI-interacting
(piRNAs),
regulate
physiological
functions
maintain
homeostasis.
are
regarded
extracellular
messengers
that
transfer
ncRNAs
between
neurons
body
fluids
due
to
ability
cross
blood-brain
barrier.
This
review
aims
summarize
current
understanding
exosomal
prospective
diagnostic
biomarkers,
pathological
regulators,
therapeutic
strategies
clinical
applications.
We
also
provide
an
all-sided
discussion
comparison
some
similar
diseases
main
limitations
challenges
