Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Advances and applications of nanoparticles in cancer therapy

MedComm – Oncology, Год журнала: 2024, Номер 3(1)

Опубликована: Март 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Язык: Английский

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Implantable, 3D-Printed Alginate Scaffolds with Bismuth Sulfide Nanoparticles for the Treatment of Local Breast Cancer via Enhanced Radiotherapy

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(13), С. 15718 - 15729

Опубликована: Март 20, 2024

Surgical removal of tumor tissue remains the primary clinical approach for addressing breast cancer; however, complete excision is challenging, and remaining cells can lead to recurrence metastasis over time, which substantially deteriorates life quality patients. With aim improve local cancer radiotherapy, this work reports fabrication alginate (Alg) scaffolds containing bovine serum albumin (BSA)-coated bismuth sulfide (Bi2S3@BSA) nanoradiosensitizers using three-dimensional (3D) printing. Under single-dose X-ray irradiation in vitro, Alg-Bi2S3@BSA significantly increase formation reactive oxygen species, enhance inhibition cells, suppress their colony capacity. In addition, implanted under murine model show high therapeutic efficacy by reducing volume growth rate irradiation, while histological observation main organs reveals no cytotoxicity or side effects. 3D-printed produced with biocompatible biodegradable materials may potentially lower rates patients inhibiting residual following postsurgery as well exhibit anticancer properties other solid tumors.

Язык: Английский

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Selenium‐Doped Nanoheterojunctions for Highly Efficient Cancer Radiosensitization

Advanced Science, Год журнала: 2024, Номер 11(29)

Опубликована: Июнь 3, 2024

Abstract Exploring efficient and low‐toxicity radiosensitizers to break through the bottleneck of radiation tolerance, immunosuppression poor prognosis remains one critical developmental challenges in radiotherapy. Nanoheterojunctions, due their unique physicochemical properties, have demonstrated excellent radiosensitization effects energy deposition lifting tumor radiotherapy inhibition. Herein, they doped selenium (Se) into prussian blue (PB) construct a nano‐heterojunction (Se@PB), which could promote increase Fe 2+ /Fe 3+ ratio conversion Se high valence state with introduction. The ‐Se‐Fe electron transfer chain accelerates rate on surface nanoparticles, turn endows it X‐ray transport capability, enhances physical sensitivity. Furthermore, Se@PB induces glutathione (GSH) depletion accumulation pro‐Fenton reaction, thereby disturbs redox balance cells biochemical sensitivity As an radiosensitizer, effectively induced mitochondrial dysfunction DNA damage, promotes cell apoptosis synergistic cervical cancer This study elucidates mechanism Se‐doped nanoheterojunction from perspective biochemistry provides low‐toxic strategy

Язык: Английский

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A Self‐Catalytic NO/O₂ Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 5, 2024

Radiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor-targeted "prosthetic-Arginine" coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O

Язык: Английский

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Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Янв. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Язык: Английский

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Extraction of Metallic Nanoparticles from Electronic Waste for Biomedical Applications: Pioneering Sustainable Technological Progress

Sustainability, Год журнала: 2025, Номер 17(5), С. 2100 - 2100

Опубликована: Фев. 28, 2025

The extraction of metallic nanoparticles (MNPs) from waste electrical and electronic equipment (WEEE) has gained extensive attention researchers for eco-friendly, reliable, sustainable alternative protocol over the traditional linear economic approach (make-use-dispose) boosting circular economy. A plethora MNPs including metals/metal oxide having a size dimension ranging 1–100 nanometers (nm) have been extracted these WEEE by using different chemical, physical, biological methods. Recovery certain precious can be achieved dismantling recycling items in form gold (Au), platinum (Pt), zinc (ZnO), silver (Ag), copper (CuO). These provide huge range applications such as antibacterial, therapeutic, target drug delivery, biotechnological applications. This comprehensive review provides in-depth knowledge synthesis techniques delves into their potential biomedical fields with mechanisms. article also discussed global challenges opportunities this area adopting concept economy to conserve natural resources future generations hence create greener environment protect our planet.

Язык: Английский

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Unraveling the complexities of colorectal cancer and its promising therapies – An updated review

International Immunopharmacology, Год журнала: 2024, Номер 143, С. 113325 - 113325

Опубликована: Окт. 14, 2024

Язык: Английский

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Application of High-Z Nanoparticles to Enhance Current Radiotherapy Treatment

Molecules, Год журнала: 2024, Номер 29(11), С. 2438 - 2438

Опубликована: Май 22, 2024

Radiotherapy is an essential component of the treatment regimens for many cancer patients. Despite recent technological advancements to improve dose delivery techniques, escalation required enhance tumor control limited due inevitable toxicity surrounding healthy tissue. Therefore, local enhancement dosing in sites can provide necessary means modality. In years, emergence nanotechnology has facilitated a unique opportunity increase efficacy radiotherapy treatment. The application high-atomic-number (Z) nanoparticles (NPs) augment effects by increasing sensitivity cells radiation. High-Z NPs inherently act as radiosensitizers well serve targeted vehicles radiosensitizing agents. this work, therapeutic benefits high-Z radiosensitizers, such their tumor-targeting capabilities and mechanisms sensitization, are discussed. Preclinical data supporting status clinical translation will be presented.

Язык: Английский

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Particle beam radiobiology status and challenges: a PTCOG Radiobiology Subcommittee report

International Journal of Particle Therapy, Год журнала: 2024, Номер 13, С. 100626 - 100626

Опубликована: Авг. 8, 2024

Particle Therapy (PT) represents a significant advancement in cancer treatment, precisely targeting tumor cells while sparing surrounding healthy tissues thanks to the unique depth-dose profiles of charged particles. Furthermore, their linear energy transfer and relative biological effectiveness enhance capability treat radioresistant tumors, including hypoxic ones. Over years, extensive research has paved way for PT's clinical application, current efforts aim refine its efficacy precision, minimizing toxicities. In this regard, radiobiology is evolving towards integrating biotechnology advance drug discovery radiotherapy (RT) optimization. This shift from basic understanding molecular mechanisms PT aims expand therapeutic window through innovative dose delivery regimens combined therapy approaches. review, written by over 30 contributors various countries, provides comprehensive look at key areas new developments radiobiology, emphasizing innovations techniques transforming field, ranging irradiation modalities multimodal radiation therapy, modeling efforts. We highlight both advancements knowledge gaps, with improving application oncology.

Язык: Английский

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