In silico and in vitro studies reveal a synergistic potential source of novel anti-ageing from two Indonesian green algae
Journal of Functional Foods,
Год журнала:
2023,
Номер
104, С. 105555 - 105555
Опубликована: Апрель 24, 2023
The
exploration
of
natural
ingredients
to
prevent
or
delay
ageing
is
fascinating
develop
in
the
industrial
technologies
nutraceuticals.
Indonesian
green
algae
(Caulerpa
racemosa
and
Caulerpa
lentillifera)
are
predicted
contain
many
bioactive
substances
that
have
not
been
studied
intensively
but
potential
be
a
source
anti-ageing.
Therefore,
this
study
examine
content
with
related
proteins
play
an
important
role
process
vitro
study.
This
reveals
novel
anti-ageing
from
two
C.
lentillifera
via
modulation
mTOR-SIRT1-AMPK
pathways
their
antioxidant
abilities.
Based
on
integration
these
silico
vitro,
candidates
for
nutraceuticals
pharmaceutical
agents,
which
supported
by
synergistic
effect
capacity
against
free
radicals
oxidative
stress.
Язык: Английский
Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives
Phytotherapy Research,
Год журнала:
2024,
Номер
38(8), С. 4053 - 4080
Опубликована: Июнь 19, 2024
Abstract
In
2022,
there
were
around
20
million
new
cases
and
over
9.7
cancer‐related
deaths
worldwide.
An
increasing
number
of
metabolites
with
anticancer
activity
in
algae
had
been
isolated
identified,
which
promising
candidates
for
cancer
therapy.
Red
are
well‐known
the
production
brominated
metabolites,
including
terpenoids
phenols,
have
capacity
to
induce
cell
toxicity.
Some
non‐toxic
biological
macromolecules,
polysaccharides,
distinct
secondary
found
many
algae,
particularly
green
algae.
They
possess
activities
by
inhibiting
tumor
angiogenesis,
stimulating
immune
response,
inducing
apoptosis.
However,
structure–activity
relationship
between
these
components
antitumor
activity,
as
well
certain
taxa
within
remains
relatively
unstudied.
This
work
is
based
on
reports
published
from
2003
2024
PubMed
ISI
Web
Science
databases.
A
comprehensive
review
characterized
algal
active
compounds,
together
their
structure
mechanism
action
was
performed.
Also,
preliminarily
summarized
better
assess
potential
properties
a
natural,
safe
bioactive
product
be
used
an
alternative
treatment
cancers,
leading
opportunities
drug
discovery.
Язык: Английский
Green seaweed Caulerpa racemosa - Chemical constituents, cytotoxicity in breast cancer cells and molecular docking simulation
Journal of Agriculture and Food Research,
Год журнала:
2023,
Номер
12, С. 100621 - 100621
Опубликована: Май 13, 2023
Marine
and
terrestrial
organisms
are
rich
in
chemical
compounds
with
medicinal
pharmacological
properties,
including
antitumor
agents
for
chemoprevention.
Caulerpa
racemosa,
a
marine
species,
is
potential
source
of
novel
therapeutic
human
cancer.
This
study
aimed
to
determine
the
anticancer
activity
C.
racemosa
extracts
breast
cancer
cells,
identify
compounds,
mechanism
using
computational
models.
Seaweed
(C.
racemosa)
was
taken
from
North
Sulawesi,
Indonesia;
Followed
by
authentication
identification
according
previously
published
protocol
extracted
three
different
solvent:
hexane,
ethyl
acetate,
ethanol.
were
evaluated
cytotoxicity
against
MCF-7
cells
MTT
(3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium
bromide)
assay.
Antioxidant
activities
assessed
based
on
free
radical
scavenging
(2,2-diphenyl-1-picrylhydrazyl
(DPPH))
ferric-reducing
antioxidant
power
(FRAP)
assays.
The
phytochemical
constituents
identified
liquid
chromatography-electrospray
ionization
quadrupole
time-of-flight
mass
spectrometry
(LC-ESI-QTOF-MS)
system.
interaction
epidermal
growth
factor
2
(HER2)
protein
achieved
molecular
docking
PyRx-vina
application
protein-ligand
complex
visualization.
hexane
extract
exhibited
highest
followed
acetate
ethanol
(IC50
23.7
±
2.0;
66.7
5.8
182.7
14.3
μg/mL).
best
sample
DPPH
21.5
2.0
μg/mL)
while
most
active
FRAP
value
(14.5
1.3
μg
gallic
acid
equivalent/g).
Data
LC-ESI-QTOF-MS
allowed
21
compounds.
showed
that
12
could
prevent
tumors
acting
as
inhibitors
anti-apoptotic
HER2
protein.
has
chemoprevention
through
its
capacity
inhibition
More
studies
needed
investigate
efficacy
Язык: Английский
Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation
BMC Complementary Medicine and Therapies,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 30, 2025
The
spreading
of
COVID-19
has
posed
a
risk
to
global
health,
especially
for
lung
cancer
patients.
An
investigation
is
needed
overcome
the
challenges
pathophysiology
and
disease.
This
study
was
designed
evaluate
phytoconstituents
in
Punica
granatum
peel
(PGP),
its
anti-lung
activity,
silico
evaluation
antiviral
potential.
GC–MS
technique
used
detect
phytoconstituents.
Cytotoxicity
analyzed
using
MTT
dye,
followed
by
apoptosis,
ROS
generation,
cell
cycle
phase
detection
human
cells
(A549).
glide
module
Maestro
software
investigate
molecular-docking
interaction
constituents
against
main
protease
(Mpro)
papain-like
(PLpro)
SARS-CoV-2.
GROMACS
2023.2
utilized
complex
stability.
A
total
nineteen
phytocomponents
were
detected
PGP
extract
through
analysis.
shown
potential
reduce
proliferation
while
evading
normal
death.
induced
apoptosis
arresting
G0/G1
generating
ROS.
six
eight
had
high
affinity
PLpro
Mpro
proteins,
respectively.
top
docked
complex,
ethyl
5-oxo-2-pyrrolidinecarboxylate,
with
showed
likely
stable
throughout
100
ns
simulation.
finding
raises
possibility
top-eight
hits
(docking
score
≥
-1.0
kcal/mol)
preventing
SARS-CoV-2
severity.
exhibited
orally
active
drugs
no
more
than
one
violation
drug-likeness
activity.
are
suggested
be
dual
agents
pathogenesis.
Язык: Английский
Unleashing the Potential of Marine Algae in Cancer Prevention and Treatment Through Combination of Tradition and Innovation
Interdisciplinary cancer research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Cancer
is
a
global
health
challenge,
with
rapidly
rising
incidence
and
significant
economic
burden.
The
urgent
need
for
innovative
approaches
to
cancer
prevention
treatment
underscored
by
its
growing
impact.
Marine
algae,
characterized
their
unique
bioactive
compounds,
have
emerged
as
promising
sources
of
novel
anticancer
agents
in
this
context.
This
chapter
reviews
the
potential
marine
algae
treatment,
emphasizing
integration
traditional
knowledge
modern
scientific
methods
develop
safe,
affordable,
accessible
drugs.
offer
rich
source
including
polysaccharides,
polyphenols,
pigments,
known
antioxidant,
anti-inflammatory,
antitumor
effects.
Moreover,
these
organisms
evolved
complex
defense
mechanisms,
making
them
particularly
interesting
drug
discovery.
Research
highlights
multifaceted
mechanisms
apoptosis
induction,
cell
cycle
arrest,
selective
cytotoxicity
against
cells.
Fucoxanthin,
fucoidan,
stigmasterol,
other
compounds
from
shown
potent
properties
through
modulation
various
signaling
pathways.
advantages
include
chemical
diversity,
sustainability,
environmentally
friendly
cultivation,
presenting
exciting
opportunities
development.
To
address
challenges
herbal
medicine,
standardization,
active
compound
identification,
rigorous
clinical
trials
are
essential.
Collaboration
between
practitioners
scientists
can
bridge
gap
wisdom
medical
standards.
Combinatorial
therapies
that
integrate
extracts
conventional
treatments
more
effective
holistic
management.
Язык: Английский