Deleted Journal, Год журнала: 2024, Номер unknown, С. 100023 - 100023
Опубликована: Окт. 1, 2024
Язык: Английский
Health Care For Women International, Год журнала: 2025, Номер unknown, С. 1 - 15
Опубликована: Март 31, 2025
Non-communicable diseases (NCDs) account for 74% of worldwide deaths annually. A search in 'Google Scholar' and 'PubMed' showed a total 224,854 articles after adjusting time period relevance, 43 were selected. Cancer, cardiovascular (CVDs), respiratory diabetes the most prevalent NCDs among females. Cancer-related females are expected to rise 5.5 million by 2030, hormonal factors, smoking, alcohol consumption obesity biggest contributors. CVD 8.94 2019, poor pregnancy outcomes fertility issues increase females' risk. Respiratory affect 6.16% young high BMI, processed food intake, Diabetes effects 9% women factors risk, whereas psychosocial may impact prevention treatment. The female NCD burden is increasing there need multi-interventional approach effectively manage these diseases.
Язык: Английский
Процитировано
0
Photodiagnosis and Photodynamic Therapy, Год журнала: 2025, Номер unknown, С. 104579 - 104579
Опубликована: Апрель 1, 2025
Fourier transform infrared (FT-IR) spectroscopy is an innovative diagnostic technique for improving early detection and personalized care breast cancer patients. It allows rapid accurate analysis of biological samples. Therefore, the purpose this study was to assess accuracy FT-IR cancer, based on a comprehensive literature review. An online electronic database systematic search conducted using PubMed/Medline, Cochrane Library, hand databases from March 28, 2024, April 10, 2024. We included peer-reviewed journal articles in which used acquire data cancers manuscripts published English. All eligible studies were assessed Quality Assessment Diagnostic Accuracy Studies (QUADAS) tool. Serum, biopsies, blood plasma, specimen, saliva samples study. This revealed that diagnosis with algorithms had sensitivity specificity 98% 100%, respectively. Almost all have more than one algorithm analyze spectral data. finding showed reported six greater 90%. Employing multivariate coupled has shown promise differentiating between healthy cancerous tissue. review will be next gold standard diagnosis. However, draw definitive conclusions, larger-scale studies, external validation, real-world clinical trials, legislative considerations, alternative methods such as Raman should considered.
Язык: Английский
Процитировано
0
Deleted Journal, Год журнала: 2025, Номер 18(1), С. 146 - 157
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
BMC Public Health, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 16, 2025
Ambient air pollution is a serious public health issue that may influence reproductive health, including fertility and menopause onset in women worldwide. Thus, understanding the risk factors associated with early crucial to inform about potential risks guide interventions. We collected data from KHANES (The Korea National Health Nutrition Examination Survey) at Korean Center for Disease Control Prevention, Ministry of Welfare between 2010 2020. These were linked summary AiMS-CREATE (AI-Machine Learning Statistics Collaborative Research Ensemble Air Pollution, Temperature, All Types Environmental Exposures) 2002 encapsulate monthly average predictions 226 si-gun-gu (cities, counties, districts) Korea. A total 8506 participants who had experienced (early menopause: 40-44 years, N = 341; normal ≥ 45 8165) 2020 included analysis. employed survey logistic regression analyses determine associations ambient after adjusting covariates. An association was observed particulate matter 2.5 (PM2.5) (adjusted (aOR): 1.26, 95% confidence interval (CI): 1.21-1.31), 10 (PM10) (aOR: 1.17, CI: 1.14-1.20). Our findings suggest exposure contribute menopause, emphasizing importance addressing quality as priority. This study highlights need further research explore underlying mechanisms long-term impacts environmental menopause.
Язык: Английский
Процитировано
0
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 187, С. 118071 - 118071
Опубликована: Апрель 19, 2025
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(18), С. e37217 - e37217
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
3
Food & Function, Год журнала: 2024, Номер 15(4), С. 2282 - 2294
Опубликована: Янв. 1, 2024
The impact of dietary saturated fatty acids (SFAs) on breast cancer risk may vary depending their carbon chain lengths, attributable to the discrepancy in sources and biological activities.
Язык: Английский
Процитировано
2
Aging, Год журнала: 2024, Номер 16(11), С. 9547 - 9557
Опубликована: Май 31, 2024
Neratinib, a typical small-molecule, pan-human tyrosine kinase inhibitor (TKI), has been licensed for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, underlying pharmacological mechanism is still unknown. In current study, we report novel function Neratinib by showing that its stimulates senescence mammary cancer AU565 cells. Our results demonstrate induces mitochondrial injury increasing reactive oxygen species (ROS) and reducing intracellular adenosine triphosphate (ATP). Also, found induced DNA damage levels 8-Hydroxy-desoxyguanosine (8-OHdG) γH2AX in Additionally, reduced telomerase activity after 7 14 days incubation. Importantly, senescence-associated-β-galactosidase (SA-β-Gal) assay revealed stimulated decreased gene reverse transcriptase (hTERT) but increased those telomeric repeat-binding (TERF2) Further study displayed upregulated expression K382 acetylation p53 (ac-K382) p21 sirtuin-1 (SIRT1). overexpression SIRT1 abolished effects cellular senescence. These findings provide strong preclinical evidence Neratinib's
Язык: Английский
Процитировано
2
TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 181, С. 118040 - 118040
Опубликована: Ноя. 8, 2024
Язык: Английский
Процитировано
2
Life, Год журнала: 2023, Номер 14(1), С. 9 - 9
Опубликована: Дек. 20, 2023
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous matrix and highly expressed in breast cancer (BC) cases at diagnosis. However, the genetic investigations for association TIMP-2 genotypes with BC risk are rather limited. In this study, contribution rs8179090, rs4789936, rs2009196 rs7342880 to was examined among Taiwan’s population. genotypic profiles were revealed 1232 controls about their using a PCR-based RFLP methodology. The rs8179090 homozygous variant CC genotype significantly higher than (odds ratio (OR) = 2.76, 95% confidence interval (95%CI) 1.78–4.28, p 0.0001). Allelic analysis showed that C allele carriers have increased (OR 1.39, 95%CI 1.20–1.62, Genotypic together allelic or not associated risk. Stratification younger (≤55) aged women, those elder (>55) age. Last, also triple negative BC. This study sheds light into etiology Taiwanese women. Rs8179090 may be incorporated polygenic scores prediction models, which could aid stratifying individuals targeted screening.
Язык: Английский
Процитировано
4