Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Год журнала: 2024, Номер 829, С. 111868 - 111868
Опубликована: Июнь 12, 2024
Язык: Английский
Pathology - Research and Practice, Год журнала: 2024, Номер 259, С. 155346 - 155346
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
4
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июнь 28, 2024
Alzheimer's disease (AD) is the leading cause of dementia globally, having a pathophysiology that complex and multifactorial. Recent findings highlight significant role non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long (lncRNAs), circular (circRNAs), piwi-interacting (piRNAs) in molecular mechanisms underlying AD. These ncRNAs are involved critical biological processes such as cell proliferation, apoptosis, oxidative stress, amyloid-beta aggregation, tau phosphorylation, neuroinflammation, autophagy, which pivotal AD development progression. This systematic review aims to consolidate current scientific knowledge on AD, making it first encompass four types associated with disease. Our comprehensive search analysis reveal not only play crucial roles pathogenesis but also hold potential biomarkers for its early detection novel therapeutic targets. Specifically, underscore significance miRNAs regulating genes key pathways activin receptor signaling pathway, actomyosin contractile ring organization, advanced glycation endproducts-receptor endproducts (AGE-RAGE) pathway. highlights unveiling diagnostic strategies, emphasizing need further research validate their clinical utility. exploration provides foundation future bioinformatic analyses ncRNA-based precision medicine approaches offering new insights into disease's pathology paving way innovative treatment strategies.
Язык: Английский
Процитировано
4
Non-Coding RNA, Год журнала: 2024, Номер 10(5), С. 50 - 50
Опубликована: Сен. 30, 2024
Introduction: Lung cancer remains one of the most prevalent and deadly cancers globally, with high mortality rates largely due to late-stage diagnosis, aggressive progression, frequent recurrence. Despite advancements in diagnostic techniques therapeutic interventions, overall prognosis for lung patients continues be dismal. Method: Emerging research has identified non-coding RNAs (ncRNAs), including microRNAs, long RNAs, circular as critical regulators gene expression, significantly influencing biology. These ncRNAs play pivotal roles various aspects pathogenesis, tumor initiation, metastasis, resistance therapy. Results: We provide a comprehensive analysis current understanding cancer, emphasizing their potential biomarkers early prognostication, prediction response. explore biological functions ncRNAs, involvement key oncogenic pathways, molecular mechanisms by which they modulate expression cellular processes cancer. Furthermore, this review highlights recent advances ncRNA-based tools strategies, such miRNA mimics inhibitors, lncRNA-targeted therapies, circRNA-modulating approaches, offering promising avenues personalized medicine. Conclusion: Finally, we discuss challenges future directions ncRNA research, need large-scale validation studies development efficient delivery systems therapies. This underscores revolutionize management providing novel options that could improve patient outcomes.
Язык: Английский
Процитировано
4
Heliyon, Год журнала: 2025, Номер unknown, С. e42961 - e42961
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Март 13, 2025
Exosomes, nanosized extracellular vesicles released by various cell types, are intensively studied for the diagnosis and treatment of cancer neurodegenerative diseases, they also display high usability in regenerative medicine. Emphasizing their diagnostic potential, exosomes serve as carriers disease-specific biomarkers, enabling non-invasive early detection personalized The cargo loading with therapeutic agents presents an innovative strategy targeted drug delivery, minimizing off-target effects optimizing interventions. In medicine, play a crucial role intercellular communication, facilitating tissue regeneration through transmission bioactive molecules. While acknowledging existing challenges standardization scalability, ongoing research efforts aim to refine methodologies address regulatory considerations. summary, this review underscores transformative potential reshaping landscape medical interventions, particular emphasis on cancer,
Язык: Английский
Процитировано
0
Cellular & Molecular Biology Letters, Год журнала: 2025, Номер 30(1)
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(2), С. 189081 - 189081
Опубликована: Янв. 26, 2024
Distant metastasis is responsible for high mortality in most cancer cases and the lung one of common target organs, severely affecting quality daily life overall survival patients. With relevant research breakthroughs accumulating, scientists have developed a deeper understanding (LM) from rudimentary "seed soil" theory to more vivid concept pre-metastatic niche (PMN). Thus, mechanisms PMN formation become considerably complicated, involving various types cells, chemokines, cytokines, proteins, providing potential biomarkers improved LM diagnosis treatment techniques. Here we summarized latest findings (in 3 years) systematically collated it basic clinical application, which clearly exhibited influences primary tumor, stromal, bone marrow-derived cells (BMDCs) associated molecules PMN.
Язык: Английский
Процитировано
3
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 172, С. 116213 - 116213
Опубликована: Фев. 1, 2024
Melanoma is one of the most lethal cutaneous malignancies. Despite great advances in radiotherapy, chemotherapy, and immunotherapy, survival rate prognosis patients with melanoma remain poor. The abundant sophisticated reciprocal communication network between cells non-tumor contributes to high heterogeneity microenvironment intimately related varying treatment responses clinical courses. Extracellular vesicles (EVs) are membrane structures generated by nearly all cell types. EVs contain biologically active molecules, mainly comprising proteins, lipids, RNAs, undoubtedly play multifaceted roles numerous diseases, represented melanoma. Non-coding RNAs (ncRNAs) encompass long non-coding microRNAs, circular constitute majority human transcriptome. Multiple ncRNAs encapsulated coordinate various pathophysiological processes This review summarizes mechanisms which EV-ncRNAs modulate biological behaviors immunity, their potential diagnostic therapeutic applications Undoubtedly, further insight into functions will contribute implementation precision medicine.
Язык: Английский
Процитировано
3
Gene, Год журнала: 2024, Номер 932, С. 148900 - 148900
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
3
Functional & Integrative Genomics, Год журнала: 2024, Номер 24(5)
Опубликована: Сен. 19, 2024
Язык: Английский
Процитировано
3