Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(11), С. 12641 - 12657
Опубликована: Ноя. 7, 2024
The oral microbiome, comprising bacteria, fungi, viruses, and protozoa, is essential for maintaining both systemic health. This complex ecosystem includes over 700 bacterial species, such as
Язык: Английский
Microorganisms, Год журнала: 2025, Номер 13(4), С. 814 - 814
Опубликована: Апрель 3, 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2024, Номер 16(17), С. 2997 - 2997
Опубликована: Авг. 28, 2024
Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.
Язык: Английский
Процитировано
6
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(47)
Опубликована: Ноя. 13, 2024
is a gram-negative anaerobic bacterium linked to periodontal disease. Remarkably,
Язык: Английский
Процитировано
5
Clinics and Practice, Год журнала: 2025, Номер 15(4), С. 80 - 80
Опубликована: Апрель 11, 2025
Background/Objectives: The diversity of the oral microbiota exerts its effects in maintaining dental and overall health. unique genetic profile each individual influences composition microbiota, determining susceptibility to certain diseases. aim is observe role by highlighting pathogenic mechanisms involved dysbiosis identify determinism's influence balance. Methods: This study was designed as a narrative review utilizing some principles guidelines systematic increase methodological rigor. We examined 121 articles such reviews, meta-analyses, editorials, observational studies, which met inclusion exclusion criteria. criteria for studies were follows: (1) that evaluated impact or/and systemic diseases; (2) observed microbiota; (3) interaction with immune system (4); implications microbiota. Results: Host genes regulate inflammatory immunological reactions play microbiological explains increased resistance diseases, including gingivitis or periodontitis. Also, are reflected not only locally, but also generally, being associated various conditions. Conclusions: Understanding determinants may help create individualized therapies preventing managing disorders. A healthy lifestyle adequate hygiene can facilitate diverse balanced microbiome, crucial
Язык: Английский
Процитировано
0
Investigative Ophthalmology & Visual Science, Год журнала: 2025, Номер 66(4), С. 68 - 68
Опубликована: Апрель 23, 2025
We studied the regulatory association of Porphyromonas gingivalis (PG) and cataracts. PCR FISH assays were used for detecting PG 16s ribosomal RNA genome, Immunofluorescence was expression RpgA in anterior capsular epithelium fibrosis markers subcapsular cataract (ASC) model. Flow cytometry reactive oxygen species apoptosis. deep sequencing is differential gene analysis. PG's positively 43.3% (101/233 cases) aqueous humor (AH) samples patients with cataracts, which differs from 4.7% (6/127) PG-positive AH glaucoma. Diabetic high myopia cataracts increase compared age-related No observed congenital positive 82% to 94% cataractous capsule tissues age-related, congenital, diabetic The cells are CD68+/CD14+ macrophages, but not epithelial cells. In rat ASC models, injected via tail vein or PG-carried bone marrow monocytes can migrate into equatorial lens form promote progression upregulation collagen, fibronectin α smooth muscle actin (α-SMA) expression, 8-OHdG levels α-SMA surrounding Kyoto Encyclopedia Genes Genomes Gene Ontology analysis dataset shows that signaling pathways related epithelial-mesenchymal transition, oxidative stress, cell death up-regulated + alone. Co-culture supernatants Raw264.7/PG+ primary increases levels, mitochondrial fission, apoptosis, α-SMA. Chronic infection access macrophages during stress conditions, promotes development by possibly elevating transition tissues. a novel risk factor development.
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(11), С. 12641 - 12657
Опубликована: Ноя. 7, 2024
The oral microbiome, comprising bacteria, fungi, viruses, and protozoa, is essential for maintaining both systemic health. This complex ecosystem includes over 700 bacterial species, such as
Язык: Английский
Процитировано
1