Adverse childhood experience is associated with an increased risk of reporting chronic pain in adulthood: a stystematic review and meta-analysis

European journal of psychotraumatology, Год журнала: 2023, Номер 14(2)

Опубликована: Ноя. 23, 2023

Background: Adverse childhood experiences (ACEs) have been shown to negatively affect health in adulthood. Estimates of associations between ACEs and chronic painful conditions are lacking.

Язык: Английский

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Traumatic Events, Posttraumatic Stress Disorder, and Central Sensitization in Chronic Pain Patients of a German University Outpatient Pain Clinic

Psychosomatic Medicine, Год журнала: 2023, Номер 85(4), С. 351 - 357

Опубликована: Фев. 21, 2023

ABSTRACT Objective Posttraumatic stress disorder (PTSD) and traumatic life events are often coupled to chronic pain, possibly linked by central sensitization. We wanted assess the prevalence of PTSD in pain patients a German university hospital outpatient clinic. Moreover, we evaluated extent indicators co-occurring traits sensitization comorbid patients. Methods retrospectively divided 914 into four groups depending on their trauma severity: no trauma, accidental interpersonal PTSD. collected electronic drawings focusing area widespreadness, as well information about intensity, sleep impairment, disability, stress, anxiety, depression, somatization. Differences between were calculated using Kruskal-Wallis with post-hoc Mann-Whitney tests. Results Of patients, 231 (25%) had 210 (23%) traumas, 283 (31%) 99 (11%) PTSD, 91 (10%) could not be classified. observed statistically significant differences maximal The severity symptoms increased severity. Conclusions Traumatic frequent negative impact sensory sensitivity (anxiety, somatization), compatible Therefore, heightened awareness comorbidity experiences is recommended.

Язык: Английский

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Digital Therapeutics (DTx) Expand Multimodal Treatment Options for Chronic Low Back Pain: The Nexus of Precision Medicine, Patient Education, and Public Health

Healthcare, Год журнала: 2023, Номер 11(10), С. 1469 - 1469

Опубликована: Май 18, 2023

Digital therapeutics (DTx, software as a medical device) provide personalized treatments for chronic diseases and expand precision medicine beyond pharmacogenomics-based pharmacotherapies. In this perspective article, we describe how DTx low back pain (CLBP) can be integrated with pharmaceutical drugs (e.g., NSAIDs, opioids), physical therapy (PT), cognitive behavioral (CBT), patient empowerment. An example of an FDA-authorized CLBP is RelieVRx, prescription virtual reality (VR) app that reduces severity adjunct treatment moderate to severe pain. RelieVRx immersive VR system delivers at-home management modalities, including relaxation, self-awareness, distraction, guided breathing, education. The mechanism action aligned recommendations from the American College Physicians use non-pharmacological modalities first-line CLBP. Herein, discuss multimodal options integrating conventional exposome-responsive, just-in-time adaptive interventions (JITAI). Given flexibility software-based therapies accommodate diverse digital content, also suggest music-induced analgesia increase clinical effectiveness offers opportunities simultaneously address crisis opioid epidemic while supporting patients healthcare providers improve outcomes.

Язык: Английский

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Stress-Induced Changes in the Endogenous Opioid System Cause Dysfunction of Pain and Emotion Regulation

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(14), С. 11713 - 11713

Опубликована: Июль 20, 2023

Early life stress, such as child abuse and neglect, psychosocial stress in adulthood are risk factors for psychiatric disorders, including depression anxiety. Furthermore, exposure to these stresses affects the sensitivity pain stimuli is associated with development of chronic pain. However, mechanisms underlying pathogenesis stress-induced depression, anxiety, control remain unclear. Endogenous opioid signaling reportedly analgesia, reward, addiction, regulation responses Stress alters expression various receptors central nervous system receptor agonists antagonists. μ-opioid receptor-deficient mice exhibit attachment disorders autism-like behavioral patterns, while those δ-opioid deficiency anxiety-like behavior. In contrast, antagonists κ-opioid suppress response. These findings strongly suggest that dysfunction endogenous pathways involved this review, we summarize latest basic clinical research studies on effects early-life

Язык: Английский

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Personalized assessment and management of non‐specific low back pain

European Journal of Pain, Год журнала: 2023, Номер 28(2), С. 181 - 198

Опубликована: Окт. 24, 2023

Abstract Background and Objective Low back pain (LBP), in particular non‐specific low (NSLBP), which accounts for approximately 90% of LBP, is the leading cause years lived with disability worldwide. In clinical trials, LBP often poorly categorized into ‘specific’ versus ‘non‐specific’ ‘acute’ ‘chronic’ pain. However, a better understanding underlying mechanisms might improve study results reduce number NSLBP patients. Databases Data Treatment Narrative review. Results multi‐dimensional, biopsychosocial condition that requires all contributing dimensions to be assessed prioritized. Thereby, assessment contribution nociceptive, neuropathic nociplastic forms basis personalized management. addition, psychosocial (e.g. anxiety, catastrophizing) contextual factors work situation) as well comorbidities need individually weighted. Personalized treatment further choosing modalities, example, exercising, patient education, cognitive‐behavioural advice, pharmacotherapy, tailoring within these delivery tailored psychological interventions or exercise programs. As main mechanism may vary over time, re‐assessment necessary success should ideally quantitatively qualitatively. Conclusions The identification integration patients' view on their condition, including beliefs, preferences, concerns expectations, are key management NSLBP. research, importance placed accurate characterization patients outcomes relevant individual patient. Significance Statement Here, comprehensive review challenges associated diagnostic label ‘non‐specific pain’ given. It outlines what lacking current guidelines it summarized currently known respect phenotyping. becomes clear more research clinically meaningful subgroups needed best tailor approaches.

Язык: Английский

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Chronic Pain, Mental Health, and Sense of Purpose in Life Among Women Living with HIV Compared to HIV-Negative Women in the British Columbia CARMA-CHIWOS Collaboration (BCC3) Study

AIDS and Behavior, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

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Childhood abuse and health outcomes in patients with fibromyalgia: a cross-sectional exploratory study of the moderating effects of pain catastrophizing and mindfulness

BMC Musculoskeletal Disorders, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 25, 2025

Childhood abuse has been linked to poorer health outcomes in individuals with fibromyalgia (FM), and this relationship may be affected by cognitive processes such as pain catastrophizing mindfulness. This study investigated the impact of childhood on pain-related symptoms functioning (FM) examined how critical psychosocial constructs mindfulness might moderate relationship. We hypothesized that would greater physical lower functioning, influencing these associations. The sample consisted 113 women FM. Correlational analyses were conducted examine between (pain severity, interference, impact, functioning). Moderation outcomes. As expected, was generally associated elevated symptomatology reduced higher levels impact. However, contrary our hypothesis, not directly or functioning. Pain significant moderators Specifically, related interference only at low high Our findings suggest while did patients, factors like play roles moderating effects. These results underscore importance assessing for psychological management fibromyalgia, especially patients a history abuse. Further research is needed explore relationships more diverse samples develop personalized targeted interventions patient population.

Язык: Английский

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Training School-Based Health Clinicians in New Mexico Regarding Adverse Childhood Experiences

Healthcare, Год журнала: 2025, Номер 13(6), С. 638 - 638

Опубликована: Март 14, 2025

Background: Adverse childhood experiences (ACEs) are potentially traumatic that may promote poor mental health, including substance use and suicidality, as well chronic pain. Telementoring be used to provide education school-based health center (SBHC) clinicians other professionals in the community identify support youth with ACEs. Methods: This study was an evaluation of novel ACEs ECHO telementoring program, which incorporates didactics, case-based learning, a practice serve New Mexico, rural state high prevalence Results: In program’s first two years, there were 704 unique participants, SBHC from 25 Mexico’s 33 counties. The pre/post survey demonstrated participants reported increases knowledge identifying children experienced (4.3 versus 3.7, p = 0.001) confidence supporting who at risk (4.1 3.3, compared before they began attending program. also felt more hopeful could help (4.2 0.001). Conclusions: program considered for states globally capacity-building model educate adverse experiences.

Язык: Английский

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Adverse childhood experiences and multisite pain among adolescents in the United States

PAIN Reports, Год журнала: 2025, Номер 10(3), С. e1279 - e1279

Опубликована: Апрель 28, 2025

Childhood adversity can have a lasting negative impact throughout one's life. Youth with pain conditions consistently report higher rate of adverse childhood experiences (ACEs) when compared their healthy peers. Adolescents experiencing in more than 1 region tend to greater symptom burden and reduced quality Research on the association between ACEs multisite adolescents is sparse. The objective our study was investigate cumulative self-report early adolescence using data from Adolescent Brain Cognitive Development study. We used 19-region body map evaluate presence regional (1-2 regions) (≥3 regions). analyzed multinominal logistic regression, adjusting for sociodemographic factors including pubertal status, sex, race/ethnicity, income-to-needs ratio. included total 7582 children aged 12 13 years, 33.4%, 24.0%, 13.2%, 8.6% reporting 1, 2, 3, 4+ ACEs, respectively. Moreover, 30.7%, 24.2%, 15.2%, 10.1% reported Those (adjusted odds ratio 1.62, 95% confidence interval 1.24-2.12) 3 1.44, 1.14-1.82) were likely no ACEs. showed potential dose-response relationship pain, suggesting that particularly may emerge earlier previously documented. Keywords: Adverse experiences, Multisite pain.

Язык: Английский

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Beyond pain catastrophizing: rationale and recommendations for targeting trauma in the assessment and treatment of chronic pain

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер 24(3), С. 231 - 234

Опубликована: Янв. 26, 2024

Язык: Английский

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