Poultry Science,
Год журнала:
2022,
Номер
102(1), С. 102258 - 102258
Опубликована: Окт. 28, 2022
We
investigated
the
effects
of
astaxanthin
supplementation
on
egg
quality,
antioxidant
capacity,
and
ovarian
aging
aged
laying
hens.
Six
groups
68-wk-old
Hy-line
brown
hens
with
six
replications
each,
fifteen
chickens
in
each
replicate
were
fed
for
12
wk.
The
control
group
was
a
basal
diet,
positive
diet
supplemented
100
mg/kg
vitamin
E,
experimental
15
mg/kg,
30
45
or
60
(Ax15,
Ax30,
Ax45,
Ax60,
respectively).
results
showed
that
accumulated
yolks
improved
yolk
color
(P
<
0.01)
Haugh
unit
0.05).
Compared
group,
higher
number
follicles
ovary
lower
rate
atresia
0.01).
Astaxanthin
increased
expression
nuclear
factor
e2-related
2
(NRF2)
0.05),
enhanced
capacity
reduced
cellular
apoptosis
In
addition,
serum
reproductive
hormone
levels
(follicle-stimulating
hormone,
luteinizing
progesterone)
0.05)
maximum
value
observed
Ax60.
However,
had
no
estrogen
level
>
FSHR
CYP11A1
follicular
granulosa
cells
Therefore,
prevented
by
improving
promoting
production
hormones.
declining
performance
late
period
may
be
supplementation.
Journal of Ovarian Research,
Год журнала:
2022,
Номер
15(1)
Опубликована: Сен. 1, 2022
Abstract
Ovarian
aging
refers
to
the
process
by
which
ovarian
function
declines
until
eventual
failure.
The
pathogenesis
of
is
complex
and
diverse;
oxidative
stress
(OS)
considered
be
a
key
factor.
This
review
focuses
on
fact
that
OS
status
accelerates
promoting
apoptosis,
inflammation,
mitochondrial
damage,
telomere
shortening
biomacromolecular
damage.
Current
evidence
suggests
aging,
smoking,
high-sugar
diets,
pressure,
superovulation,
chemotherapeutic
agents
industrial
pollutants
can
factors
accelerate
exacerbating
status.
In
addition,
we
role
nuclear
factor
E2-related
2
(Nrf2),
Sirtuin
(Sirt),
mitogen-activated
protein
kinase
(MAPK),
B
(AKT),
Forkhead
box
O
(FoxO)
Klotho
signaling
pathways
during
aging.
We
also
explore
antioxidant
therapies
such
as
melatonin,
vitamins,
stem
cell
therapies,
monomers
Traditional
Chinese
Medicine
(TCM),
investigate
roles
these
supplements
with
respect
reduction
improvement
function.
provides
rationale
for
therapy
improve
Cells,
Год журнала:
2022,
Номер
11(8), С. 1367 - 1367
Опубликована: Апрель 17, 2022
Alzheimer's
Disease
(AD)
is
a
progressive
neurodegenerative
disease
characterized
by
amyloid-β
(Aβ)
plaque
deposition
and
neurofibrillary
tangle
accumulation
in
the
brain.
Although
several
studies
have
been
conducted
to
unravel
complex
interconnected
pathophysiology
of
AD,
clinical
trial
failure
rates
high,
no
disease-modifying
therapies
are
presently
available.
Fluid
biomarker
discovery
for
AD
rapidly
expanding
field
research
aimed
at
anticipating
diagnosis
following
progression
over
time.
Currently,
Aβ
Ageing Research Reviews,
Год журнала:
2023,
Номер
85, С. 101854 - 101854
Опубликована: Янв. 17, 2023
Telomere
attrition
is
considered
a
hallmark
of
ageing.
Untangling
the
proximate
causes
telomere
may
therefore
reveal
important
aspects
about
ageing
process.
In
landmark
paper
in
2002
Thomas
von
Zglinicki
demonstrated
that
oxidative
stress
accelerates
cell
culture.
next
20
years,
became
firmly
embedded
into
modern
theories
and
attrition.
However,
recent
surge
vivo
studies
reveals
an
inconsistent
pattern
questioning
unequivocal
role
length
(henceforth
referred
to
as
dynamics),
living
organisms.
Here
we
report
results
first
formal
meta-analysis
on
association
between
dynamics
vivo,
representing
37
studies,
4969
individuals,
18,677
correlational
measurements.
The
overall
correlation
markers
was
indistinguishable
from
zero
(r
=
0.027).
This
result
independent
type
marker,
dynamic,
or
taxonomic
group.
measurement
method
affected
analysis
subset
TRF-based
showed
significant
0.09),
supporting
prediction
more
pronounced
short-lived
species
during
adult
life
phase,
when
becomes
apparent.
We
then
performed
additional
interventional
(n
7)
manipulating
stress.
revealed
effect
treatment
(d=0.36).
Our
findings
provide
new
support
for
hypothesis
Antioxidants,
Год журнала:
2024,
Номер
13(4), С. 394 - 394
Опубликована: Март 25, 2024
Under
normal
physiological
conditions,
reactive
oxygen
species
(ROS)
are
produced
through
redox
reactions
as
byproducts
of
respiratory
and
metabolic
activities.
However,
due
to
various
endogenous
exogenous
factors,
the
body
may
produce
excessive
ROS,
which
leads
oxidative
stress
(OS).
Numerous
studies
have
shown
that
OS
causes
a
variety
pathological
changes
in
cells,
including
mitochondrial
dysfunction,
DNA
damage,
telomere
shortening,
lipid
peroxidation,
protein
modification,
all
can
trigger
apoptosis
senescence.
also
induces
aging-related
diseases,
such
retinal
disease,
neurodegenerative
osteoarthritis,
cardiovascular
cancer,
ovarian
prostate
disease.
In
this
review,
we
aim
introduce
multiple
internal
external
triggers
mediate
ROS
levels
rodents
humans
well
relationship
between
OS,
aging,
diseases.
Finally,
present
statistical
analysis
effective
antioxidant
measures
currently
being
developed
applied
field
aging
research.
Redox Biology,
Год журнала:
2023,
Номер
62, С. 102659 - 102659
Опубликована: Март 7, 2023
Reactive
oxygen
species
(ROS)
are
mainly
produced
in
mitochondria
and
involved
various
physiological
activities
of
the
ovary
through
signaling
critical
for
regulating
ovarian
cycle.
Notably,
imbalance
between
ROS
generation
antioxidant
defense
system
contributes
to
development
diseases.
These
contradictory
effects
have
implications
potential
strategies
that
aim
scavenge
excessive
ROS.
However,
much
remains
be
learned
about
how
causes
diseases
application
therapy
Here,
we
review
mechanisms
maintenance
homeostasis
its
associated
effects.
Additionally,
highlighted
pathological
treatment.
Journal of Ovarian Research,
Год журнала:
2023,
Номер
16(1)
Опубликована: Апрель 6, 2023
Ovarian
aging
is
a
natural
and
physiological
process
characterized
by
loss
of
quantity
quality
oocyte
or
follicular
pool.
As
it
generally
accepted
that
women
are
born
with
finite
follicle
pool
will
go
through
constant
decline
without
renewing,
which,
together
decreased
quality,
makes
severe
situation
for
who
advanced
age
but
desperate
healthy
baby.
The
aim
our
review
was
to
investigate
mechanisms
leading
ovarian
discussing
both
extra-
intra-
factors
identify
genetic
characteristics
aging.
were
identified
as
extra-ovarian
alternation
hypothalamic-pituitary-ovarian
axis
intra-ovarian
ovary
itself,
including
telomere,
mitochondria,
oxidative
stress,
DNA
damage,
protein
homeostasis,
aneuploidy,
apoptosis
autophagy.
Moreover,
here
we
reviewed
related
Genome-wide
association
studies
(GWAS
studies)
from
2009
2021
next
generation
sequencing
(NGS)
primary
insufficiency
(POI)
in
order
describe
It
reasonable
wish
more
reliable
anti-aging
interventions
the
exploration
genetics
being
progressing.
Nature Aging,
Год журнала:
2024,
Номер
4(1), С. 145 - 162
Опубликована: Янв. 10, 2024
Abstract
Ovarian
aging
leads
to
diminished
fertility,
dysregulated
endocrine
signaling
and
increased
chronic
disease
burden.
These
effects
begin
emerge
long
before
follicular
exhaustion.
Female
humans
experience
a
sharp
decline
in
fertility
around
35
years
of
age,
which
corresponds
declines
oocyte
quality.
Despite
growing
body
work,
the
field
lacks
comprehensive
cellular
map
transcriptomic
changes
mouse
ovary
identify
early
drivers
ovarian
decline.
To
fill
this
gap
we
performed
single-cell
RNA
sequencing
on
tissue
from
young
(3-month-old)
reproductively
aged
(9-month-old)
mice.
Our
analysis
revealed
doubling
immune
cells
ovary,
with
lymphocyte
proportions
increasing
most,
was
confirmed
by
flow
cytometry.
We
also
found
an
age-related
downregulation
collagenase
pathways
stromal
fibroblasts,
rises
fibrosis.
Follicular
displayed
stress-response,
immunogenic
fibrotic
pathway
inductions
aging.
This
report
provides
critical
insights
into
mechanisms
responsible
for
phenotypes.
The
data
can
be
explored
interactively
via
Shiny-based
web
application.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 1, 2023
Normal
levels
of
reactive
oxygen
species
(ROS)
play
an
important
role
in
regulating
follicular
growth,
angiogenesis
and
sex
hormone
synthesis
ovarian
tissue.
When
the
balance
between
ROS
antioxidants
is
disrupted,
however,
it
can
cause
serious
consequences
oxidative
stress
(OS),
quantity
quality
oocytes
will
decline.
Therefore,
this
review
discusses
interrelationship
OS
premature
insufficiency
(POI),
potential
mechanisms
methods
by
which
improve
POI
through
controlling
level
OS.
We
found
that
mediate
changes
genetic
materials,
signal
pathways,
transcription
factors
microenvironment,
resulting
abnormal
apoptosis
granulosa
cells
(GCs)
meiosis
as
well
decreased
mitochondrial
Deoxyribonucleic
Acid(mtDNA)
other
changes,
thus
accelerating
process
aging.
However,
antioxidants,
mesenchymal
stem
(MSCs),
biological
enzymes
delay
disease
reducing
vivo
.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
144, С. 112001 - 112001
Опубликована: Окт. 6, 2021
Melatonin,
mostly
released
by
the
pineal
gland,
is
a
circadian
rhythm-regulated
and
multifunctional
hormone.
Great
advances
in
melatonin
research
have
been
made,
including
its
role
rhythms
of
sleep-wake
cycle,
retardation
ageing
processes,
as
well
antioxidant
or
anti-inflammatory
functions.
Melatonin
can
scavenge
free
radicals
such
reactive
oxygen
species
(ROS),
key
factor
reproductive
plays
an
important
oocyte
maturation,
fertilization
embryonic
development
well.
The
concurrent
use
increases
number
mature
oocytes,
rate,
high-quality
embryos,
which
improves
clinical
outcome
assisted
technology
(ART).
This
review
discusses
relationship
between
human
function,
potential
applications
field
medicine.
