LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review DOI Creative Commons

Arash Esmaeili,

Niloufar Yazdanpanah, Nima Rezaei

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2025, Номер 45(1)

Опубликована: Март 8, 2025

CNS diseases account for a major part of the comorbidity and mortality human population; moreover, neuroinflammation has become an indication different diseases, instance, Parkinson's Alzheimer's disease. Microglia astrocytes are two main glial cells that can be found in CNS. Each these plays important role mediating immune responses like inflammation. There many studies suggesting LncRNAs neuroinflammation. Indeed, orchestrate through various mechanisms, namely miRNA sponge, transcriptional activation/inhibition. In addition, regulate downstream pathways NF-κB, PI3K/AKT. this study, we gathered existing regarding mechanisms action pathogenesis neurodegenerative traumatic injuries regulating We aim to elaborate on regulatory roles bring more profound understanding etiology terms

Язык: Английский

The Bio‐Hermes Study: Biomarker database developed to investigate blood‐based and digital biomarkers in community‐based, diverse populations clinically screened for Alzheimer's disease DOI Creative Commons
Richard C. Mohs,

Douglas W. Beauregard,

John Dwyer

и другие.

Alzheimer s & Dementia, Год журнала: 2024, Номер 20(4), С. 2752 - 2765

Опубликована: Фев. 28, 2024

Abstract INTRODUCTION Alzheimer's disease (AD) trial participants are often screened for eligibility by brain amyloid positron emission tomography/cerebrospinal fluid (PET/CSF), which is inefficient as many not positive. Use of blood‐based biomarkers may reduce screen failures. METHODS We recruited 755 non‐Hispanic White, 115 Hispanic, 112 Black, and 19 other minority across groups cognitively normal ( n = 417), mild cognitive impairment 312), or AD 272) participants. Plasma beta (Aβ)40, Aβ42, Aβ42/Aβ40, total tau, phosphorylated tau (p‐tau)181, p‐tau217 were measured; PET/CSF 956) determined positivity. Clinical, blood biomarker, ethnicity/race differences associated with status evaluated. RESULTS Greater impairment, older age, carrying an apolipoprotein E (apoE) ε4 allele greater burden. Areas under the receiver operating characteristic curve plasma p‐tau181, positivity ≥ 0.7117 all ethnoracial (p‐tau217, ≥0.8128). Age apoE adjustments imputation biomarker values outside limit quantitation provided small improvement in predictive power. DISCUSSION Blood‐based highly results diverse populations enrolled at clinical sites. Highlights Amyloid (Aβ)42/Aβ40, p‐tau 217 predicted P‐tau was strongest predictor Biomarkers from ethnic, racial, cohorts Community‐based have similar levels populations. A prescreen process assays number

Язык: Английский

Процитировано

19
Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations DOI Creative Commons

L. Krishaa,

Ted Kheng Siang Ng, Hai Ning Wee

и другие.

Mechanisms of Ageing and Development, Год журнала: 2023, Номер 211, С. 111787 - 111787

Опубликована: Фев. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Growing evidence suggests the gut microbiome (GM) plays pivotal role in pathogenesis AD through microbiota-gut-brain axis (MGB). Alterations GM composition and diversity have been observed both animal models human patients with AD. dysbiosis has implicated increased intestinal permeability, blood-brain barrier (BBB) impairment, neuroinflammation development hallmarks Further elucidation could pave way for holistic predictive methods determining risk progression disease. Furthermore, accumulating modulation alleviate adverse symptoms or serve as preventive measure. In addition, increasing shows Type 2 Diabetes Mellitus (T2DM) often comorbid AD, common alterations inflammatory response, which chart GM-related treatment interventions diseases. We conclude by exploring therapeutic potential alleviating reducing risk. we also propose future directions research, namely fecal microbiota transplantation (FMT) precision medicine.

Язык: Английский

Процитировано

30
Sensitive label-free detection of the biomarker phosphorylated tau−217 protein in Alzheimer's disease using a graphene-based solution-gated field effect transistor DOI

Sian-Hong Ciou,

Ao-Ho Hsieh,

Yu-Xiu Lin

и другие.

Biosensors and Bioelectronics, Год журнала: 2023, Номер 228, С. 115174 - 115174

Опубликована: Март 12, 2023

Язык: Английский

Процитировано

24
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease DOI Creative Commons
Jangampalli Adi Pradeepkiran,

Javaria Baig,

Md Ariful Islam

и другие.

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Alzheimer's disease (AD) is a age-related neurodegenerative and major public health concern both in Texas, US Worldwide. This mainly characterized by amyloid-beta (Aβ) phosphorylated Tau (p-Tau) accumulation the brains of patients with AD increasing evidence suggests that these are key biomarkers AD. Both Aβ p-tau can be detected through various imaging techniques (such as positron emission tomography, PET) cerebrospinal fluid (CSF) analysis. The presence individuals, who asymptomatic or have mild cognitive impairment indicate an increased risk developing future. Furthermore, combination often used for more accurate diagnosis prediction progression. Along being disease, it associated other chronic conditions such cardiovascular obesity, depression, diabetes because studies shown comorbid make people vulnerable to In first part this review, we discuss biofluid-based Aβ, p-Tau & plasma could alternative sensitive technique diagnose second part, underlying molecular mechanisms linked how they affect clinical care.

Язык: Английский

Процитировано

14
Pathogenesis, Diagnostics, and Therapeutics for Alzheimer's Disease: Breaking the Memory Barrier DOI Creative Commons

Pushpa Tryphena Kamatham,

Rashi K. Shukla, Dharmendra Kumar Khatri

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102481 - 102481

Опубликована: Сен. 3, 2024

Alzheimer's disease (AD) is the most common cause of dementia and accounts for 60-70 % all cases. It affects millions people worldwide. AD poses a substantial economic burden on societies healthcare systems. progressive neurodegenerative disorder characterized by cognitive decline, memory loss, impaired daily functioning. As prevalence continues to increase, understanding its pathogenesis, improving diagnostic methods, developing effective therapeutics have become paramount. This comprehensive review delves into intricate mechanisms underlying AD, explores current state techniques, examines emerging therapeutic strategies. By revealing complexities this aims contribute growing body knowledge surrounding devastating disease.

Язык: Английский

Процитировано

13
Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease DOI Creative Commons

Anchal Trisal,

Abhishek Kumar Singh

Neuroscience, Год журнала: 2025, Номер 567, С. 235 - 248

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides DOI Creative Commons
Florina Zákány, István M. Mándity, Zoltán Varga

и другие.

Cells, Год журнала: 2023, Номер 12(13), С. 1700 - 1700

Опубликована: Июнь 23, 2023

Every cell biological textbook teaches us that the main role of plasma membrane is to separate cells from their neighborhood allow for a controlled composition intracellular space. The mostly hydrophobic nature presents an impenetrable barrier most hydrophilic molecules larger than 1 kDa. On other hand, cell-penetrating peptides (CPPs) are capable traversing this without compromising integrity, and they can do so on own or coupled cargos. Coupling biologically medically relevant cargos CPPs holds great promise delivering membrane-impermeable drugs into cells. If cargo able interact with certain types, uptake CPP–drug complex be tailored cell-type-specific. Besides outlining major penetration pathways CPPs, review aimed at deciphering how properties influence mechanisms CPPs. By summarizing extensive body experimental evidence, we argue more ordered, less flexible structure, often present in very diseases planned treated decreases cellular uptake. These correlations not only understanding biology but also rationally improving value translational clinical applications.

Язык: Английский

Процитировано

18
Aerobic exercise suppresses cognitive injury in patients with Alzheimer’s disease by regulating long non-coding RNA TUG1 DOI
Jiaojiao Chen,

Caixia Su,

Zhezhe Ma

и другие.

Neuroscience Letters, Год журнала: 2024, Номер 826, С. 137732 - 137732

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

6
Epigenetic Peripheral Biomarkers for Early Diagnosis of Alzheimer’s Disease DOI Open Access
Chiara Villa, Andrea Stoccoro

Genes, Год журнала: 2022, Номер 13(8), С. 1308 - 1308

Опубликована: Июль 22, 2022

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the leading cause of cognitive impairment dementia in older individuals throughout world. The main hallmarks AD include brain atrophy, extracellular deposition insoluble amyloid-β (Aβ) plaques, intracellular aggregation protein tau neurofibrillary tangles. These pathological modifications start many years prior to clinical manifestations

Язык: Английский

Процитировано

25
The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies DOI Creative Commons
Yu Zhan, Murad Al‐Nusaif, Cong Ding

и другие.

Frontiers in Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Апрель 27, 2023

Being isolated from the peripheral system by blood–brain barrier, brain has long been considered a completely impervious tissue. However, recent findings show that gut microbiome (GM) influences gastrointestinal and disorders such as Alzheimer’s disease (AD). Despite several hypotheses, neuroinflammation, tau hyperphosphorylation, amyloid plaques, neurofibrillary tangles, oxidative stress, being proposed to explain origin progression of AD, pathogenesis remains incompletely understood. Epigenetic, molecular, pathological studies suggest GM AD development have endeavored find predictive, sensitive, non-invasive, accurate biomarkers for early diagnosis monitoring progression. Given growing interest in involvement current research endeavors identify prospective both preclinical clinical diagnoses, well targeted therapy techniques. Here, we discuss most on changes microbiome-based biomarkers, diagnostic uses, approaches. Furthermore, addressed herbal components, which could provide new venue research.

Язык: Английский

Процитировано

15