International Journal of Secondary Metabolite,
Год журнала:
2024,
Номер
11(1), С. 63 - 77
Опубликована: Янв. 25, 2024
Withania
somnifera
has
been
used
for
a
long
time
in
traditional
medicine.
Its
crude
extract,
dried
powder,
and
purified
metabolites
from
mature
plants
have
shown
promising
therapeutic
potential.
To
further
investigate
its
potential,
the
detection
of
phytochemicals
with
anticancer
antimicrobial
properties
vegetative
stage
is
essential.
Hence,
this
study
was
done
to
identify
phytochemical
constituents
using
GC-MS
analysis
activities
methanolic
extracts
stem,
leaf,
root
W.
somnifera.
The
air-dried
plant
parts
were
extracted
methanol
at
low
pressure
concentrate
rotary
evaporator
40°C.
phytochemicals,
Shimadzu
GCMSQP2010,
Japan,
NIST107.LIB
database.
identified
35
unique
peaks
In
leaves,
antibacterial
included
cyclotrisiloxane,
hexamethyl,
high
abundance,
cyclohexasiloxane,
dodecamethyl,
least
abundance.
roots,
2,2-dimethoxybutane,
cathinone,
found
properties,
whereas
trans-2,3-epoxyoctane,
properties.
phytoconstituents
octasiloxane,
1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl,
benzenemethanol,
alpha.-(1-aminoethyl),
be
most
abundant
abundant,
respectively,
while
arabinitol
pentaacetate
had
both
activities.
At
stage,
studies
revealed
occurrence
potential
Heliyon,
Год журнала:
2023,
Номер
9(2), С. e13684 - e13684
Опубликована: Фев. 1, 2023
Bioactive
compounds
are
crucial
for
an
extensive
range
of
therapeutic
uses,
and
some
exhibit
anticancer
activity.
Scientists
advocate
that
phytochemicals
modulate
autophagy
apoptosis,
involved
in
the
underlying
pathobiology
cancer
development
regulation.
The
pharmacological
aiming
autophagy-apoptosis
signaling
pathway
using
phytocompounds
hence
offers
auspicious
method
is
complementary
to
conventional
chemotherapy.
current
review
aims
explore
molecular
level
autophagic-apoptotic
know
its
implication
essential
cellular
process
as
a
druggable
target
emergence
naturally
derived
phytocompound-based
agents.
data
were
collected
from
scientific
databases
such
Google
search,
Web
Science,
PubMed,
Scopus,
Medline,
Clinical
Trials.
With
broad
outlook,
we
investigated
their
cutting-edge
scientifically
revealed
and/or
searched
pharmacologic
effects,
novel
mechanism
action,
therapy.
In
this
review,
evidence
focused
on
pharmacology,
specifically
caspase,
Nrf2,
NF-kB,
pathway,
several
mechanisms
understand
role
biology.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(11), С. 6075 - 6075
Опубликована: Май 28, 2022
Autophagy
is
an
evolutionarily
conserved
process
for
the
degradation
of
redundant
or
damaged
cellular
material
by
means
a
lysosome-dependent
mechanism,
contributing
to
cell
homeostasis
and
survival.
plays
multifaceted
context-dependent
role
in
cancer
initiation,
maintenance,
progression;
it
has
tumor
suppressive
absence
disease
upregulated
cells
meet
their
elevated
metabolic
demands.
represents
promising
but
challenging
target
treatment.
Green
tea
widely
used
beverage
with
healthy
effects
on
several
diseases,
including
cancer.
The
bioactive
compounds
green
are
mainly
catechins,
epigallocatechin-gallate
(EGCG)
most
abundant
biologically
active
among
them.
In
this
review,
evidence
autophagy
modulation
anti-cancer
induced
EGCG
treatment
experimental
models
presented.
Reviewed
articles
reveal
that
promotes
cytotoxic
often
through
inactivation
PI3K/Akt/mTOR
pathway,
resulting
apoptosis
induction.
pro-oxidant
activity
been
postulated
be
responsible
its
effects.
combination
therapy
chemotherapy
drug,
inhibits
growth
drug-induced
pro-survival
autophagy.
selected
studies
rightly
claim
as
valuable
agent
chemoprevention.
Saudi Journal of Biological Sciences,
Год журнала:
2021,
Номер
28(12), С. 6730 - 6747
Опубликована: Июль 21, 2021
Breast
cancer
(BC)
has
high
incidence
and
mortality
rates,
making
it
a
major
global
health
issue.
BC
treatment
been
challenging
due
to
the
presence
of
drug
resistance
limited
availability
therapeutic
options
for
triple-negative
metastatic
BC,
thereby
urging
exploration
more
effective
anti-cancer
agents.
Hesperidin
its
aglycone
hesperetin,
two
flavonoids
from
citrus
species,
have
extensively
evaluated
their
potentials.
In
this
review,
available
literatures
on
chemotherapeutic
chemosensitising
activities
hesperidin
hesperetin
in
preclinical
models
are
reported.
The
safety
bioavailability
as
well
strategies
enhance
also
discussed.
Overall,
can
inhibit
cell
proliferation,
migration
stem
cells
induce
apoptosis
cycle
arrest
vitro.
They
tumour
growth,
metastasis
neoplastic
changes
tissue
architecture
vivo.
Moreover,
co-administration
or
with
doxorubicin,
letrozole
tamoxifen
efficacies
these
clinically
These
linked
several
mechanisms,
including
modulation
signalling
pathways,
glucose
uptake,
enzymes,
miRNA
expression,
oxidative
status,
regulatory
proteins,
suppressor
p53,
plasma
liver
lipid
profiles
DNA
repair
mechanisms.
However,
poor
water
solubility,
extensive
phase
II
metabolism
apical
efflux
posed
limitations
hesperetin.
Various
enhancement
studied,
utilisation
nano-based
delivery
systems
other
flavonoids.
particular,
nanoformulated
possess
greater
than
free
compounds.
Despite
promising
results,
further
efficacy
evaluation
nanoformulations
clinical
trials
is
required
ascertain
potentials
be
developed
useful
agents
treatment.
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Янв. 26, 2022
The
key
tumor
suppressor
protein
p53,
additionally
known
as
represents
an
attractive
target
for
the
development
and
management
of
anti-cancer
therapies.
p53
has
been
implicated
a
that
multiple
aspects
biological
function
comprising
energy
metabolism,
cell
cycle
arrest,
apoptosis,
growth
differentiation,
senescence,
oxidative
stress,
angiogenesis,
cancer
biology.
Autophagy,
cellular
self-defense
system,
is
evolutionarily
conserved
catabolic
process
involved
in
various
physiological
processes
maintain
homeostasis.
Numerous
studies
have
found
modulates
autophagy,
although
relationship
between
autophagy
relatively
complex
not
well
understood.
Recently,
several
experimental
reported
can
act
both
inhibitor
activator
which
depend
on
its
localization
mode
action.
Emerging
evidences
suggested
dual
role
suppresses
stimulates
cencer
cells.
It
suppression
activation
are
important
to
modulate
promotion
treatment.
On
other
hand,
by
recommended
protective
p53.
Therefore,
elucidation
new
functions
could
contribute
novel
therapeutic
approaches
However,
underlying
molecular
mechanisms
shows
reciprocal
functional
interaction
major
importance
treatment
manegement.
Additionally,
synthetic
drugs
phytochemicals
targeted
signaling
via
regulation
pathway
This
review
emphasizes
current
perspectives
main
regulator
autophagy-mediated
against
managements.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15765 - 15765
Опубликована: Дек. 12, 2022
Cancer
is
one
of
the
deadliest
non
communicable
diseases.
Numerous
anticancer
medications
have
been
developed
to
target
molecular
pathways
driving
cancer.
However,
there
has
no
discernible
increase
in
overall
survival
rate
cancer
patients.
Therefore,
innovative
chemo-preventive
techniques
and
agents
are
required
supplement
standard
treatments
boost
their
efficacy.
Fruits
vegetables
should
be
tapped
into
as
a
source
compounds
that
can
serve
therapy.
Phytochemicals
play
an
important
role
sources
new
medication
treatment.
Some
synthetic
natural
chemicals
effective
for
chemoprevention,
i.e.,
use
exogenous
medicine
inhibit
or
impede
tumor
development.
They
help
regulate
linked
development
spread
enhance
antioxidant
status,
inactivating
carcinogens,
suppressing
proliferation,
inducing
cell
cycle
arrest
death,
regulating
immune
system.
While
focusing
on
four
main
categories
plant-based
agents,
epipodophyllotoxin,
camptothecin
derivatives,
taxane
diterpenoids,
vinca
alkaloids
mode
action,
we
review
effects
phytochemicals,
like
quercetin,
curcumin,
piperine,
epigallocatechin
gallate
(EGCG),
gingerol.
We
examine
different
signaling
associated
with
how
inflammation
key
mechanism
growth.
Pharmaceuticals,
Год журнала:
2022,
Номер
15(2), С. 144 - 144
Опубликована: Янв. 26, 2022
The
potential
of
gossypol
and
its
R-(-)-enantiomer
(R-(-)-gossypol
acetic
acid,
AT-101),
has
been
evaluated
for
treatment
cancer
as
an
independent
agent
in
combination
with
standard
chemo-radiation-therapies,
respectively.
This
review
assesses
the
evidence
safety
clinical
effectiveness
oral
gossypol/AT-101
treating
various
types
cancer.
databases
PubMed,
MEDLINE,
Cochrane,
ClinicalTrials.gov
were
examined.
Phase
I
II
trials
well
single
arm
randomized
included
this
review.
Results
screened
to
determine
if
they
met
inclusion
criteria
then
summarized
using
a
narrative
approach.
A
total
17
involving
759
patients
criteria.
Overall,
orally
applied
at
low
doses
(30
mg
daily
or
lower)
was
determined
tolerable
either
monotherapy
chemo-radiation.
Adverse
events
should
be
strictly
monitored
successfully
managed
by
dose-reduction
symptoms.
There
are
four
trials,
two
performed
advanced
non-small
cell
lung
cancer,
one
subjects
head
neck
metastatic
castration-resistant
prostate
Thereby,
chemotherapy
(either
docetaxel
(two
trials)
plus
cisplatin
prednisone)
tested
without
AT-101.
Within
these
benefit
observed
high-risk
some
prolongation
progression-free
survival
overall
survival.
Strikingly,
most
recent
trial
combined
dose
AT-101
docetaxel,
fluorouracil,
radiation,
achieving
complete
responses
11
13
gastroesophageal
carcinoma
(median
duration
12
months)
median
52
months.
promising
results
shown
subsets
supports
need
further
specification
sensitive
cancers
establishment
effective
AT-101-based
therapy.
In
addition,
lowest
recommended
precise
toxicity
profile
confirmed
studies.
Randomized
placebo-controlled
validate
data
large
cohorts.
