Recent advance of herbal medicines in cancer- a molecular approach

Heliyon, Journal Year: 2023, Volume and Issue: 9(2), P. e13684 - e13684

Published: Feb. 1, 2023

Bioactive compounds are crucial for an extensive range of therapeutic uses, and some exhibit anticancer activity. Scientists advocate that phytochemicals modulate autophagy apoptosis, involved in the underlying pathobiology cancer development regulation. The pharmacological aiming autophagy-apoptosis signaling pathway using phytocompounds hence offers auspicious method is complementary to conventional chemotherapy. current review aims explore molecular level autophagic-apoptotic know its implication essential cellular process as a druggable target emergence naturally derived phytocompound-based agents. data were collected from scientific databases such Google search, Web Science, PubMed, Scopus, Medline, Clinical Trials. With broad outlook, we investigated their cutting-edge scientifically revealed and/or searched pharmacologic effects, novel mechanism action, therapy. In this review, evidence focused on pharmacology, specifically caspase, Nrf2, NF-kB, pathway, several mechanisms understand role biology.

Language: Английский

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Unboxing the molecular modalities of mutagens in cancer

Environmental Science and Pollution Research, Journal Year: 2021, Volume and Issue: 29(41), P. 62111 - 62159

Published: Oct. 5, 2021

Language: Английский

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The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 6075 - 6075

Published: May 28, 2022

Autophagy is an evolutionarily conserved process for the degradation of redundant or damaged cellular material by means a lysosome-dependent mechanism, contributing to cell homeostasis and survival. plays multifaceted context-dependent role in cancer initiation, maintenance, progression; it has tumor suppressive absence disease upregulated cells meet their elevated metabolic demands. represents promising but challenging target treatment. Green tea widely used beverage with healthy effects on several diseases, including cancer. The bioactive compounds green are mainly catechins, epigallocatechin-gallate (EGCG) most abundant biologically active among them. In this review, evidence autophagy modulation anti-cancer induced EGCG treatment experimental models presented. Reviewed articles reveal that promotes cytotoxic often through inactivation PI3K/Akt/mTOR pathway, resulting apoptosis induction. pro-oxidant activity been postulated be responsible its effects. combination therapy chemotherapy drug, inhibits growth drug-induced pro-survival autophagy. selected studies rightly claim as valuable agent chemoprevention.

Language: Английский

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Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

Saudi Journal of Biological Sciences, Journal Year: 2021, Volume and Issue: 28(12), P. 6730 - 6747

Published: July 21, 2021

Breast cancer (BC) has high incidence and mortality rates, making it a major global health issue. BC treatment been challenging due to the presence of drug resistance limited availability therapeutic options for triple-negative metastatic BC, thereby urging exploration more effective anti-cancer agents. Hesperidin its aglycone hesperetin, two flavonoids from citrus species, have extensively evaluated their potentials. In this review, available literatures on chemotherapeutic chemosensitising activities hesperidin hesperetin in preclinical models are reported. The safety bioavailability as well strategies enhance also discussed. Overall, can inhibit cell proliferation, migration stem cells induce apoptosis cycle arrest vitro. They tumour growth, metastasis neoplastic changes tissue architecture vivo. Moreover, co-administration or with doxorubicin, letrozole tamoxifen efficacies these clinically These linked several mechanisms, including modulation signalling pathways, glucose uptake, enzymes, miRNA expression, oxidative status, regulatory proteins, suppressor p53, plasma liver lipid profiles DNA repair mechanisms. However, poor water solubility, extensive phase II metabolism apical efflux posed limitations hesperetin. Various enhancement studied, utilisation nano-based delivery systems other flavonoids. particular, nanoformulated possess greater than free compounds. Despite promising results, further efficacy evaluation nanoformulations clinical trials is required ascertain potentials be developed useful agents treatment.

Language: Английский

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Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(7), P. 4384 - 4404

Published: May 12, 2022

Language: Английский

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p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic Targets

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Jan. 26, 2022

The key tumor suppressor protein p53, additionally known as represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated a that multiple aspects biological function comprising energy metabolism, cell cycle arrest, apoptosis, growth differentiation, senescence, oxidative stress, angiogenesis, cancer biology. Autophagy, cellular self-defense system, is evolutionarily conserved catabolic process involved in various physiological processes maintain homeostasis. Numerous studies have found modulates autophagy, although relationship between autophagy relatively complex not well understood. Recently, several experimental reported can act both inhibitor activator which depend on its localization mode action. Emerging evidences suggested dual role suppresses stimulates cencer cells. It suppression activation are important to modulate promotion treatment. On other hand, by recommended protective p53. Therefore, elucidation new functions could contribute novel therapeutic approaches However, underlying molecular mechanisms shows reciprocal functional interaction major importance treatment manegement. Additionally, synthetic drugs phytochemicals targeted signaling via regulation pathway This review emphasizes current perspectives main regulator autophagy-mediated against managements.

Language: Английский

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Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol

Phytomedicine, Journal Year: 2022, Volume and Issue: 99, P. 154012 - 154012

Published: March 3, 2022

Language: Английский

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Multiple health benefits of curcumin and its therapeutic potential

Environmental Science and Pollution Research, Journal Year: 2022, Volume and Issue: 29(29), P. 43732 - 43744

Published: April 20, 2022

Language: Английский

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Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(24), P. 15765 - 15765

Published: Dec. 12, 2022

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target molecular pathways driving cancer. However, there has no discernible increase in overall survival rate cancer patients. Therefore, innovative chemo-preventive techniques and agents are required supplement standard treatments boost their efficacy. Fruits vegetables should be tapped into as a source compounds that can serve therapy. Phytochemicals play an important role sources new medication treatment. Some synthetic natural chemicals effective for chemoprevention, i.e., use exogenous medicine inhibit or impede tumor development. They help regulate linked development spread enhance antioxidant status, inactivating carcinogens, suppressing proliferation, inducing cell cycle arrest death, regulating immune system. While focusing on four main categories plant-based agents, epipodophyllotoxin, camptothecin derivatives, taxane diterpenoids, vinca alkaloids mode action, we review effects phytochemicals, like quercetin, curcumin, piperine, epigallocatechin gallate (EGCG), gingerol. We examine different signaling associated with how inflammation key mechanism growth.

Language: Английский

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Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(2), P. 144 - 144

Published: Jan. 26, 2022

The potential of gossypol and its R-(-)-enantiomer (R-(-)-gossypol acetic acid, AT-101), has been evaluated for treatment cancer as an independent agent in combination with standard chemo-radiation-therapies, respectively. This review assesses the evidence safety clinical effectiveness oral gossypol/AT-101 treating various types cancer. databases PubMed, MEDLINE, Cochrane, ClinicalTrials.gov were examined. Phase I II trials well single arm randomized included this review. Results screened to determine if they met inclusion criteria then summarized using a narrative approach. A total 17 involving 759 patients criteria. Overall, orally applied at low doses (30 mg daily or lower) was determined tolerable either monotherapy chemo-radiation. Adverse events should be strictly monitored successfully managed by dose-reduction symptoms. There are four trials, two performed advanced non-small cell lung cancer, one subjects head neck metastatic castration-resistant prostate Thereby, chemotherapy (either docetaxel (two trials) plus cisplatin prednisone) tested without AT-101. Within these benefit observed high-risk some prolongation progression-free survival overall survival. Strikingly, most recent trial combined dose AT-101 docetaxel, fluorouracil, radiation, achieving complete responses 11 13 gastroesophageal carcinoma (median duration 12 months) median 52 months. promising results shown subsets supports need further specification sensitive cancers establishment effective AT-101-based therapy. In addition, lowest recommended precise toxicity profile confirmed studies. Randomized placebo-controlled validate data large cohorts.

Language: Английский

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