Toxin Reviews,
Год журнала:
2023,
Номер
42(3), С. 573 - 582
Опубликована: Апрель 27, 2023
Pyrethroids
are
popular
insecticides.
Shortness
of
breath
and
dyspnea
key
signs
exposure;
however,
their
respiratory
effects
rarely
studied.
This
study
investigated
the
combination
ratios
specific
blood
tests
lung
lesions
as
cypermethrin
(CY)
in
rabbits.
The
CY
at
various
doses
times
novelty
this
study.
Doses
(50,
100,
150
mg.kg-1
body
weight)
were
injected
intraperitoneally
every
week
for
up
to
9
weeks
rabbits
assigned
into
four
equal
groups.
Data
analysis
revealed
signs,
significantly
(p
≤
0.05)
lower
fibrinogen,
higher
neutrophils-lymphocytes
(NL),
LDH-lymphocytes
(LL),
De-Ritis
(DR),
lungs.
frequency
incidence
these
dose
dosage
dependent.
leads
pulmonary
allergic
effects.
Lung
injury
increases
cell-free
heme
plasma,
causing
edema
with
hemolysis.
Emphysema
fibrosis
followed
migration
basophils
mononuclear
cells
inferred
that
exposure
caused
NL,
LL,
DR
ratios,
lesions,
which
forecast
poor
immunity,
especially
increased
risk
cardiac
diseases.
Biomedicines,
Год журнала:
2022,
Номер
10(9), С. 2179 - 2179
Опубликована: Сен. 2, 2022
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
powerful
non-viral
carrier
for
drug
delivery.
With
the
prevalence
of
respiratory
diseases,
particularly
highlighted
by
current
COVID-19
pandemic,
investigations
into
applying
LNPs
to
deliver
inhaled
therapeutics
directly
lungs
are
underway.
The
progress
in
LNP
development
well
recent
pre-clinical
studies
three
main
classes
encapsulated
drugs:
small
molecules,
nucleic
acids
and
proteins/peptides
will
be
discussed.
advantages
pulmonary
delivery
system
such
reducing
systemic
toxicity
enabling
higher
local
concentration
evaluated
together
with
challenges
design
considerations
improved
formulations.
This
review
provides
perspective
on
future
prospects
LNP-mediated
diseases.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(4), С. 3376 - 3376
Опубликована: Фев. 8, 2023
Lung
macrophages
(Mφs)
are
essential
for
pulmonary
innate
immunity
and
host
defense
due
to
their
dynamic
polarization
phenotype
shifts.
Mesenchymal
stromal
cells
(MSCs)
have
secretory,
immunomodulatory,
tissue-reparative
properties
shown
promise
in
acute
chronic
inflammatory
lung
diseases
COVID-19.
Many
beneficial
effects
of
MSCs
mediated
through
interaction
with
resident
alveolar
interstitial
Mφs.
Bidirectional
MSC-Mφ
communication
is
achieved
direct
contact,
soluble
factor
secretion/activation,
organelle
transfer.
The
microenvironment
facilitates
MSC
secretion
factors
that
result
Mφ
towards
an
immunosuppressive
M2-like
the
restoration
tissue
homeostasis.
turn
can
affect
immune
regulatory
function
engraftment
reparatory
effects.
This
review
article
highlights
mechanisms
crosstalk
between
Mφs
potential
role
repair
diseases.
Frontiers in Microbiology,
Год журнала:
2022,
Номер
13
Опубликована: Окт. 6, 2022
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
that
causes
disease
19
(COVID-19)
has
numerous
risk
factors
leading
to
severe
with
high
mortality
rate.
Oxidative
stress
excessive
production
of
reactive
oxygen
species
(ROS)
lower
glutathione
(GSH)
levels
seems
be
a
common
pathway
associated
the
COVID-19
mortality.
GSH
is
unique
small
but
powerful
molecule
paramount
for
life.
It
sustains
adequate
redox
cell
signaling
since
physiologic
level
oxidative
fundamental
controlling
life
processes
via
signaling,
oxidation
and
tissue
damage.
The
water-soluble
tripeptide
(γ-L-glutamyl-L-cysteinyl-glycine)
present
in
cytoplasm
all
cells.
at
1–10
mM
concentrations
mammalian
tissues
(highest
concentration
liver)
as
most
abundant
non-protein
thiol
protects
against
stress.
also
activates
Kelch-like
ECH-associated
protein
1
(Keap1)-Nuclear
factor
erythroid
2-related
(Nrf2)-antioxidant
response
element
(ARE)
regulator
pathway,
releasing
Nrf2
regulate
expression
genes
control
antioxidant,
inflammatory
immune
system
responses,
facilitating
activity.
exists
thiol-reduced
disulfide-oxidized
(GSSG)
forms.
Reduced
prevailing
form
accounting
>98%
total
GSH.
GSSG
their
molar
ratio
are
indicators
functionality
its
alteration
related
various
human
pathological
including
COVID-19.
plays
prominent
role
SARS-CoV-2
infection
following
recognition
viral
S-protein
by
angiotensin
converting
enzyme-2
receptor
pattern
receptors
like
toll-like
4,
activation
transcription
nuclear
kappa
B,
subsequently
activate
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
oxidase
(NOX)
succeeded
ROS
production.
depletion
may
have
pathophysiology,
host
severity
Therapies
enhancing
could
become
cornerstone
reduce
fatal
outcomes
increasing
prevent
subdue
disease.
value
makes
research
field
biology
medicine
key
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Март 4, 2022
The
pathogenetic
mechanism
of
post-Covid-19
pulmonary
fibrosis
is
currently
a
topic
intense
research
interest,
but
still
largely
unexplored.
aim
this
work
was
to
carry
out
systematic
exploratory
search
the
literature
(Scoping
review)
identify
and
systematize
main
mechanisms
that
are
believed
be
involved
in
phenomenon,
order
highlight
same
molecular
aspect
lung.
These
aims
could
essential
future
for
therapeutic
management.
We
identified
all
primary
studies
involving
post
COVID19
syndrome
with
as
endpoint
by
performing
data
searches
various
review
databases.
Two
reviewers
independently
reviewed
abstracts
(398)
full
text
data.
quality
study
has
been
assess
through
SANRA
protocol.
A
total
32
were
included,
included
possible
involvement
inflammatory
cytokines,
concerned
renin-angiotensin
system,
potential
role
galectin-3,
epithelial
injuries
fibrosis,
alveolar
type
2
involvement,
Neutrophil
extracellular
traps
(NETs)
others
implied
other
specific
aspects
(relationship
clinical
mechanical
factors,
transition
mesenchymal,
TGF-β
signaling
pathway,
midkine,
caspase
macrophages,
genetics).
In
most
cases,
these
narrative
reviews
or
letters
editor,
except
10
articles,
which
presented
original
data,
albeit
sometimes
experimental
models.
From
development
researches,
progress
knowledge
phenomenon
hopefully
its
prevention
therapy
may
originate.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 14, 2023
Pulmonary
alveolar
proteinosis
(PAP)
is
a
rare
pulmonary
disorder
that
characterized
by
the
abnormal
accumulation
of
surfactant
within
alveoli.
Alveolar
macrophages
(AMs)
have
been
identified
as
playing
pivotal
role
in
pathogenesis
PAP.
In
most
PAP
cases,
disease
triggered
impaired
cholesterol
clearance
AMs
depend
on
granulocyte-macrophage
colony-stimulating
factor
(GM-CSF),
resulting
defective
and
disruption
homeostasis.
Currently,
novel
pathogenesis-based
therapies
are
being
developed
target
GM-CSF
signaling,
homeostasis,
immune
modulation
AMs.
this
review,
we
summarize
origin
functional
PAP,
well
latest
therapeutic
strategies
aimed
at
addressing
disease.
Our
goal
to
provide
new
perspectives
insights
into
thereby
identify
promising
treatments
for
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 27, 2024
Abstract
Background
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
with
different
antigenic
variants,
has
posed
a
significant
threat
to
public
health.
It
is
urgent
develop
inhalable
vaccines,
instead
of
injectable
elicit
mucosal
immunity
against
viral
infections.
Methods
We
reported
an
hybrid
nanovaccine
(NV
RBD
-MLipo)
boost
protective
SARS-CoV-2
infection.
Nanovesicles
derived
from
genetically
engineered
293T
cells
expressing
)
were
fused
pulmonary
surfactant
(PS)-biomimetic
liposomes
containing
MPLA
(MLipo)
yield
NV
-MLipo,
which
possessed
virus-biomimetic
structure,
inherited
expression
and
versatile
properties.
Results
In
contrast
subcutaneous
vaccination,
via
could
efficiently
enter
the
alveolar
macrophages
(AMs)
AMs
activation
through
MPLA-activated
TLR4/NF-κB
signaling
pathway.
Moreover,
-MLipo
induced
T
B
activation,
high
level
RBD-specific
IgG
secretory
IgA
(sIgA),
thus
elevating
systemic
immune
responses,
while
reducing
side
effects.
also
demonstrated
broad-spectrum
neutralization
activity
(WT,
Delta,
Omicron)
pseudovirus,
protected
immunized
mice
WT
pseudovirus
Conclusions
This
as
effective
safe
nanovaccine,
holds
huge
potential
provoke
robust
immunity,
might
be
promising
vaccine
candidate
combat
infectious
diseases,
including
COVID-19
influenza.
