The role of macrophages polarization in sepsis-induced acute lung injury

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 24, 2023

Sepsis presents as a severe infectious disease frequently documented in clinical settings. Characterized by its systemic inflammatory response syndrome, sepsis has the potential to trigger multi-organ dysfunction and can escalate becoming life-threatening. A common fallout from is acute lung injury (ALI), which often progresses respiratory distress syndrome (ARDS). Macrophages, due their significant role immune system, are receiving increased attention studies. Macrophage polarization process that hinges on an intricate regulatory network influenced myriad of signaling molecules, transcription factors, epigenetic modifications, metabolic reprogramming. In this review, our primary focus classically activated macrophages (M1-like) alternatively (M2-like) two paramount phenotypes instrumental sepsis’ host response. An imbalance between M1-like M2-like precipitate onset exacerbate progression sepsis. This review provides comprehensive understanding interplay macrophage sepsis-induced (SALI) elaborates intervention strategy centers around crucial polarization.

Язык: Английский

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Cigarette Smoke-Induced Respiratory Response: Insights into Cellular Processes and Biomarkers

Antioxidants, Год журнала: 2023, Номер 12(6), С. 1210 - 1210

Опубликована: Июнь 3, 2023

Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ diseases owing to its high content of harmful chemicals reactive oxygen species (ROS). These substances are known induce oxidative stress, inflammation, apoptosis, senescence due their exposure environmental pollutants the presence enzymes. The lung is particularly susceptible stress. Persistent stress caused by chronic CS can lead respiratory such as obstructive pulmonary disease (COPD), fibrosis (PF), cancer. Avoiding pollutants, like cigarette air pollution, help mitigate A comprehensive understanding impact on lungs requires future research. This includes identifying strategies preventing treating well investigating underlying mechanisms behind Thus, this review aims investigate cellular processes induced CS, specifically senescence, associated biomarkers. Furthermore, will delve into alveolar response provoked emphasizing roles potential therapeutic target markers in inflammation

Язык: Английский

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MSCs alleviate LPS-induced acute lung injury by inhibiting the proinflammatory function of macrophages in mouse lung organoid–macrophage model

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Март 11, 2024

Abstract Acute lung injury (ALI) is an inflammatory disease associated with alveolar injury, subsequent macrophage activation, cell infiltration, and cytokine production. Mesenchymal stem cells (MSCs) are beneficial for application in the treatment of diseases due to their immunomodulatory effects. However, mechanisms regulatory effects by MSCs on macrophages ALI need more in-depth study. Lung tissues were collected from mice mouse organoid construction. Alveolar (AMs) derived bronchoalveolar lavage interstitial (IMs) tissue co-cultured, novel matrigel-spreading organoids construct vitro model organoids–immune cells. Mouse compact bone-derived co-cultured organoids–macrophages confirm therapeutic effect acute injury. Changes transcriptome expression profile analyzed RNA sequencing. Well-established expressed various type-specific markers. grown spreading matrigel had property functional growing outside lumen. Lipopolysaccharide (LPS)-induced promoted chemotaxis toward enhanced inflammation-associated genes inflammation-injured compared controls. Treatment inhibited progress reduced levels components. Furthermore, through nuclear factor-κB pathway, MSC phenotypic transformation AMs modulated antigen-presenting function IMs, thereby affecting phenotype organoids. facilitate reception external stimuli construction models containing immune cells, which a potential research. exert protective against regulating different functions IMs lung, indicating mechanism intervention.

Язык: Английский

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Mannosylated polydopamine nanoparticles alleviate radiation- induced pulmonary fibrosis by targeting M2 macrophages and inhibiting the TGF-β1/Smad3 signaling pathway

Colloids and Surfaces B Biointerfaces, Год журнала: 2023, Номер 227, С. 113353 - 113353

Опубликована: Май 15, 2023

Язык: Английский

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Improving the Wound Healing Process: Pivotal role of Mesenchymal stromal/stem Cells and Immune Cells

Stem Cell Reviews and Reports, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Язык: Английский

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Improving the therapeutic profile of MSCs: Cytokine priming reduces donor-dependent heterogeneity and enhances their immunomodulatory capacity

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 17, 2025

Introduction MSCs exhibit regenerative, anti-inflammatory and immunomodulatory properties due to the large amount of cytokines, chemokines growth factors they secrete. have been extensively evaluated in clinical trials, however, some cases their therapeutic effects are variable. Therefore, strategies improve potential, such as preconditioning with proinflammatory factors, proposed. Several priming approaches provided non-conclusive results, duration on MSC or response a second inflammatory stimulus not fully addressed. Methods We investigated impact triple cytokine characterization viability, transcriptomic profile, functionality innate acquired immune cells, well maintenance over time, subsequent responsiveness stimulus. Results Priming cytokines (CK-MSCs) do modify differentiation capacity MSCs, nor immunophenotype viability. Moreover, enhances against NK dendritic while maintaining same T cell unstimulated MSCs. Thus, decrease T-lymphocytes proliferation, inhibit allostimulatory cells promote monocytes an immunosuppressive profile. In addition, we shown for first time that reduces variability between different donors origins. Finally, effect CK-MSC is maintained even after secondary Conclusions Cytokine-priming improves potential inter-donor variability.

Язык: Английский

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CD177 neutrophils exacerbate septic lung injury via the NETs/AIM2 pathway: An experimental and bioinformatics study

International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114292 - 114292

Опубликована: Фев. 24, 2025

Язык: Английский

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Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis

Frontiers in Digital Health, Год журнала: 2025, Номер 7

Опубликована: Март 4, 2025

Background Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life patients, especially after global COVID-19 pneumonia. The application nanotechnology in acute promising. In response to knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis explore research profile thematic trends field. Methods Articles reviews related 2004 2023 were searched. Java-based Citespace, VOSviewer, R software-based Bibiometrix used systematically evaluate publications by spatiotemporal distribution, author subject categories, topic references, keywords. Results A total 1,347 included. number papers has grown exponentially over past 20 years. China was most productive country out all 53 countries, followed United States. Chinese Academy Sciences institution with 76 papers. PARTICLE AND FIBRE TOXICOLOGY journal. top five high-frequency keywords inflammation, oxidative stress, toxicity, vitro , respiratory-distress-syndrome. And emerging delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are focus current research. Two areas represented development trends: novel nanocarriers higher efficiency lower biotoxicity, other impact nanomaterials progression injury. Conclusion field been period last three Delivery,targeted exosm have this trends:novel biotoxicity such as exosomes solid lipid nanoparticles,

Язык: Английский

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Human Mesenchymal Stem Cell Therapy: Potential Advances for Reducing Cystic Fibrosis Infection and Organ Inflammation

Best Practice & Research Clinical Haematology, Год журнала: 2025, Номер unknown, С. 101602 - 101602

Опубликована: Март 1, 2025

Язык: Английский

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The impact of the immune system on lung injury and regeneration in COPD

European Respiratory Journal, Год журнала: 2023, Номер 62(4), С. 2300589 - 2300589

Опубликована: Авг. 31, 2023

COPD is a devastating respiratory condition that manifests via persistent inflammation, emphysema development and small airway remodelling. Lung regeneration defined as the ability of lung to repair itself after injury by proliferation differentiation progenitor cell populations, becomes impaired in consequence intrinsic epithelial stem defects signals from micro-environment. Although loss structural integrity regenerative capacity are critical for disease progression, our understanding cellular players molecular pathways hamper remains limited. Intriguingly, despite being key driver pathogenesis, role immune system regulating mechanisms understudied. In this review, we summarise recent evidence on contribution cells regeneration. We focus four main axes: 1) which myeloid cause alveolar degradation; 2) formation tertiary lymphoid structures production autoreactive antibodies; 3) consequences inefficient apoptotic removal; 4) effects innate adaptive signalling differentiation. finally provide insight how technological advances omics technologies human ex vivo models can delineate cell-epithelium cross-talk expedite precision pro-regenerative approaches toward reprogramming niche treat COPD.

Язык: Английский

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